公开(公告)号：US20240424103A1

公开(公告)日：2024-12-26

申请号：US18702620

申请日：2022-10-20

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF TSUKUBA ,  TAIYO SERVICE INC.

Inventor： Yasushi IWATA ,  Hirofumi MATSUI ,  Iwane SUZUKI ,  Yuji SUZUKI ,  Kanako TOMITA ,  Tianjing YANG ,  Takafumi IKEDA ,  Hiromi KUROKAWA

IPC: A61K41/00 ,  A61K31/197 ,  A61K31/513 ,  A61K47/68 ,  A61N5/10 ,  A61P35/00 ,  G21K5/04

Abstract: Provided is an anticancer agent containing a substance that contains nitrogen-15 and that specifically accumulates in a cancer cell. Also provided is a method for killing a cancer cell in vitro, including accumulating nitrogen-15 in a cancer cell in vitro and irradiating the cancer cell with a proton beam in vitro. Additionally provided is a cancer treatment method including causing an accumulation of the nitrogen-15 in a cancer cell in a human or a nonhuman animal and irradiating the human or the nonhuman animal with a proton beam.

公开(公告)号：US20240412330A1

公开(公告)日：2024-12-12

申请号：US18699428

申请日：2022-10-12

Applicant: UNIVERSITY OF TSUKUBA

Inventor： Yoshiaki YASUNO ,  Lida ZHU ,  Shuichi MAKITA

IPC: G06T5/50 ,  G06T5/70

Abstract: An information processing device includes a reception unit that receives a plurality of OCT images captured under different image-capturing conditions and represented by complex signals, an image processing unit that performs digital refocusing by complex signal processing or digital aberration correction by the complex signal processing on each of the plurality of OCT images received by the reception unit, and a synthesis unit that synthesizes the plurality of OCT images on which the image processing unit has performed the digital refocusing by the complex signal processing or the digital aberration correction by the complex signal processing.

公开(公告)号：US20240347240A1

公开(公告)日：2024-10-17

申请号：US18637555

申请日：2024-04-17

Applicant: LG INNOTEK CO., LTD. ,  UNIVERSITY OF TSUKUBA

Inventor： Hyunseok LIM ,  Seok Bae ,  Yuto Morishita ,  Yosuke Harashima ,  Yasuteru Shigeta ,  Masafuyu Matsui ,  Rie Umetsu

IPC: H01F1/047

CPC classification number: H01F1/047

Abstract: A MnBi-based magnet according to an embodiment includes crystal grains of (MnBi)aMb composition including a manganese element, a bismuth and a M element, wherein the M element is contained an amount of more than 0 at % and less than or equal to 10 at % when at % for all atoms of (MnBi)aMb is 100 at %, and the M element includes a chromium element, a germanium element, or a tellurium element.

公开(公告)号：US20240277642A1

公开(公告)日：2024-08-22

申请号：US18567577

申请日：2022-05-23

Applicant: UNIVERSITY OF TSUKUBA

Inventor： Yukio NAGASAKI ,  Yutaka IKEDA ,  Yuya TAJIKA

IPC: A61K31/19 ,  A61K47/60 ,  A61P25/08 ,  A61P35/00 ,  C08F293/00

CPC classification number: A61K31/19 ,  A61K47/60 ,  A61P25/08 ,  A61P35/00 ,  C08F293/00

Abstract: Provided is a valproic acid derivative for improving disadvantages or defects accompanying when valproic acid itself or the like is used as a medicine. Provided is a block copolymer which is a polymerized product of valproic acid and comprises a poly(ethylene glycol) segment and a poly(vinyl valproate) segment.

公开(公告)号：US20240123261A1

公开(公告)日：2024-04-18

申请号：US18376923

申请日：2023-10-05

Applicant: UNIVERSITY OF TSUKUBA ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  DAICO MFG CO., LTD.

Inventor： Hiroaki KUMADA ,  Naoyuki KITAMURA ,  Tetsuyuki NAKAMURA ,  Takeshi IKEDA

IPC: A61N5/10

CPC classification number: A61N5/1077 ,  A61N5/1031 ,  A61N2005/1035 ,  A61N2005/109 ,  A61N2005/1094

Abstract: The purpose is to prevent the irradiation beam from leaking between the beam irradiation port of the radiation therapy device and the patient affected area that is the target of the emitted irradiation beam, a radiation shielding jig comprising a tare filled with shielding material particles; the tare is made of a resin fabric and has a hollow three-dimensional shape with a radiation pathway portion, the shielding material particles comprising a mixture of sintered particles having a predetermined particle diameter with radiation shielding performance and resin particles having a predetermined particle diameter.

公开(公告)号：US11944579B2

公开(公告)日：2024-04-02

申请号：US16327806

申请日：2017-08-24

Applicant: CYBERDYNE Inc. ,  University of Tsukuba

Inventor： Yoshiyuki Sankai

IPC: A61H3/00 ,  A61B5/291 ,  A61B5/296 ,  A61B5/344 ,  A61B5/389 ,  A61B10/00 ,  A61F2/72 ,  A61H1/02 ,  B25J9/00 ,  B25J11/00 ,  B25J13/08 ,  B25J19/02

CPC classification number: A61H1/0262 ,  A61B5/291 ,  A61B5/296 ,  A61B5/344 ,  A61B5/389 ,  A61B10/00 ,  A61F2/72 ,  A61H3/00 ,  B25J9/0006 ,  B25J11/00 ,  B25J13/08 ,  B25J19/02 ,  A61B2505/09 ,  A61H2003/007 ,  A61H2201/1626 ,  A61H2201/1642 ,  A61H2201/1652 ,  A61H2201/5007 ,  A61H2201/5061 ,  A61H2230/085 ,  A61H2230/105

Abstract: A biological activity detection apparatus includes: a drive unit that actively or passively drives in conjunction with a limb motion of a subject; a periarticular detection unit that detects a periarticular physical quantity around a joint in association with the limb motion of the subject based on an output signal from the drive unit; a biological signal detection unit located at a body surface site of the subject with reference to the joint and includes an electrode group for detecting a biological signal of the subject, wherein an activity status of a musculoskeletal system and/or a transmission status of a peripheral nervous system around the joint are converted into quantitative musculoskeletal system data and/or nervous system data on the basis of the physical quantity acquired from the periarticular detection unit and a myogenic potential signal and a neural transmission signal which are acquired from the biological signal processing unit.

公开(公告)号：US11939219B2

公开(公告)日：2024-03-26

申请号：US17418119

申请日：2019-12-26

Applicant: SUMITOMO ELECTRIC INDUSTRIES, LTD. ,  UNIVERSITY OF TSUKUBA

Inventor： Toshihiko Fujimori ,  Takeshi Hikata ,  Soichiro Okubo ,  Jun-ichi Fujita

IPC: C01B32/16 ,  B01J23/745 ,  B01J35/02 ,  C01B32/168 ,  H01B1/06 ,  H01B1/16

CPC classification number: C01B32/16 ,  B01J23/745 ,  B01J35/023 ,  C01B32/168 ,  H01B1/06 ,  H01B1/16 ,  C01P2004/04 ,  C01P2004/13

Abstract: The carbon nanotube assembled wire includes a plurality of carbon nanotubes oriented at a degree of orientation of 0.9 or more and 1 or less.

公开(公告)号：US11934558B2

公开(公告)日：2024-03-19

申请号：US17309845

申请日：2019-12-18

Applicant: University of Tsukuba

Inventor： Akira Imakura ,  Tetsuya Sakurai

IPC: G06F21/62 ,  G06V30/414

CPC classification number: G06F21/6254 ,  G06F21/6227 ,  G06V30/414

Abstract: A distributed data integration device includes an acquisition unit configured to acquire, for a piece of analysis target data, an anchor data intermediate representation and an analysis target intermediate representation, the anchor data intermediate representation being an intermediate representation obtained by converting anchor data by a first function, the anchor data being data commonly used in integration of a plurality of the pieces of analysis target data that are distributed, the analysis target intermediate representation being an intermediate representation obtained by converting the analysis target data by the first function, an anchor data conversion unit configured to convert, for the piece of analysis target data, a plurality of the anchor data intermediate representations by a second function, a calculation unit configured to calculate, for the piece of analysis target data, the second function that minimizes a difference between the plurality of the anchor data intermediate representations, and an analysis target data conversion unit configured to convert, for the piece of analysis target data, the analysis target intermediate representation by the second function.

公开(公告)号：US11787037B2

公开(公告)日：2023-10-17

申请号：US15733744

申请日：2019-03-20

Applicant: University of Tsukuba

Inventor： Sho Sakaino

IPC: B25J3/00 ,  B25J9/16 ,  B25J13/08

CPC classification number: B25J3/00 ,  B25J9/1697 ,  B25J13/085

Abstract: [Problem] Learning of object operation skills robust against variation of conditions is implemented.
[Solution] A behavior estimation apparatus 100 includes a collection unit 200 configured to collect skill data obtained when a slave robot is operated under a plurality of different conditions by using a bilateral system capable of operating the slave robot via a master robot through bidirectional control between the master robot and the slave robot. The behavior estimation apparatus 100 further includes a behavior estimation device 300 configured to estimate a command value for causing the slave robot 520 to automatically behave, based on the skill data collected by the collection unit 200 and a response output from the slave robot 520.

公开(公告)号：US11673867B2

公开(公告)日：2023-06-13

申请号：US16772314

申请日：2018-12-11

Applicant: University of Tsukuba ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Hiroshi Nagase ,  Tsuyoshi Saitoh ,  Masashi Yanagisawa ,  Yoko Irukayama

IPC: C07D239/10 ,  A61P3/04 ,  A61P3/10 ,  A61P25/24 ,  A61P25/26 ,  A61P25/00 ,  A61K9/00

CPC classification number: C07D239/10 ,  A61K9/0053 ,  A61P25/00

Abstract: The present invention aims to provide a novel low-molecular-weight compound showing an orexin receptor agonist activity and expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the like. The present invention provides a compound represented by the formula (I):




wherein each symbol is as described in the description, or a pharmaceutically acceptable acid addition salt thereof, which has an orexin receptor agonist activity, and an orexin receptor agonist containing the compound or a pharmaceutically acceptable acid addition salt thereof.