-
公开(公告)号：US10011632B2
公开(公告)日：2018-07-03
申请号：US14917127
申请日：2012-08-21
Applicant: Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
Inventor： Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
IPC: C07K5/02 , A61K51/04 , C07D249/06 , C07D249/04 , A61K51/08 , C07K5/062 , C07K5/072 , C07D403/12 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D401/12 , C07D403/06 , C07D405/12 , C07D239/60 , C07D251/30 , C07D263/34 , C07D207/16 , C07D277/56 , C07D209/48 , A61K38/00
CPC classification number: C07K5/0215 , A61K38/00 , A61K51/0402 , A61K51/0453 , A61K51/0497 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
Abstract: Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
-
公开(公告)号：US09005577B2
公开(公告)日：2015-04-14
申请号：US12433211
申请日：2009-04-30
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Umesh B. Gangadharmath , Gang Chen , Vani P. Mocharla , Dhanalakshmi Kasi , Peter J. H. Scott , Qianwa Liang
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Umesh B. Gangadharmath , Gang Chen , Vani P. Mocharla , Dhanalakshmi Kasi , Peter J. H. Scott , Qianwa Liang
CPC classification number: A61K51/088 , G01N33/60 , G01N2333/96466
Abstract: The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
Abstract translation: 本申请涉及包含放射性标记和底物，包含放射性标记的成像剂的药物组合物的放射性标记的成像剂，以及使用放射性标记的成像剂的方法。 本申请进一步涉及制备放射性标记的成像剂的方法。 这些成像剂可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
-
公开(公告)号：US20120302755A1
公开(公告)日：2012-11-29
申请号：US13477095
申请日：2012-05-22
Applicant: Anna Katrin Szardenings , Hartmuth C. Kolb , Joseph C. Walsh , Gang Chen , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Wei Zhang , Kai Chen , Vani P. Mocharla , Peter J.H. Scott
Inventor： Anna Katrin Szardenings , Hartmuth C. Kolb , Joseph C. Walsh , Gang Chen , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Wei Zhang , Kai Chen , Vani P. Mocharla , Peter J.H. Scott
IPC: C07D471/04 , C07D471/14
CPC classification number: A61K51/0455 , A61K51/0446 , C07B59/002 , C07D471/04 , C07D471/14
Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
Abstract translation: 本文公开了在哺乳动物中诊断阿尔茨海默病或倾向于其的化合物和方法，所述方法包括向哺乳动物施用诊断有效量的放射性标记的化合物，其中所述化合物选自放射性标记的咔唑及其衍生物，以及 三唑衍生物，允许化合物分布到脑组织中并对脑组织进行成像，其中与正常对照水平的结合相比，化合物与脑组织的结合增加表明哺乳动物患有或处于危险中 发展为阿尔茨海默病。
-
公开(公告)号：US20090010846A1
公开(公告)日：2009-01-08
申请号：US12098390
申请日：2008-04-04
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Umesh B. Gangadharmath , Farhad Karimi , Henry Clifton Padgett , Dhanalakshmi Kasi , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Brian A. Duclos , Tieming Zhao
IPC: A61K51/04 , C07D403/12 , A61P35/00
CPC classification number: C07D403/06 , C07B59/002 , C07D403/12
Abstract: The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.
Abstract translation: 本发明涉及用于体内检测缺氧性肿瘤或缺血组织的式I的新型放射性标记的生物可降解示踪剂。 在一个实施方案中，示踪剂由2-硝基咪唑部分，三唑，具有药代动力学增强取代基的代谢稳定接头和放射性同位素组成。 优选的体内成像模式是正电子发射断层摄影。
-
公开(公告)号：US20160304555A1
公开(公告)日：2016-10-20
申请号：US14917127
申请日：2012-08-21
Applicant: Eric WANG , Hartmuth C. KOLB , Anna Katrin INGS , Changhui LIU , Joseph C. WALSH , Gang CHEN , Anjana SINHA , Dhanalakshmi KASI , Chul YU , Umesh B. GANGADHARMATH , Wei ZHANG , Tieming ZHAO , Vani P. MOCHARLA
Inventor： Eric Wang , Hartmuth C. Kolb , Anna Katrin Szardenings , Changhui Liu , Joseph C. Walsh , Gang Chen , Anjana Sinha , Dhanalakshmi Kasi , Chul Yu , Umesh B. Gangadharmath , Wei Zhang , Tieming Zhao , Vani P. Mocharla
IPC: C07K5/02 , A61K51/04 , A61K51/08 , C07D249/06 , C07D249/04
CPC classification number: C07K5/0215 , A61K38/00 , A61K51/0453 , A61K51/088 , C07D207/16 , C07D209/48 , C07D213/81 , C07D213/82 , C07D233/78 , C07D233/96 , C07D239/60 , C07D249/04 , C07D249/06 , C07D251/30 , C07D263/34 , C07D277/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07K5/06026 , C07K5/06113
Abstract: Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
Abstract translation: 公开了靶向化合物和成像剂，前列腺特异性膜抗原（PSMA）。 还公开了合成化合物和成像剂的方法以及PSMA成像方法。 所公开的成像剂适用于PET和SPECT成像。
-
Patent Agency Ranking
公开(公告)号：US20100074843A1
公开(公告)日：2010-03-25
申请号：US12433211
申请日：2009-04-30
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Umesh B. Gangadharmath , Gang Chen , Vani P. Mocharla , Dhanalakshmi Kasi , Peter J.H. Scott , Qianwa Liang
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Umesh B. Gangadharmath , Gang Chen , Vani P. Mocharla , Dhanalakshmi Kasi , Peter J.H. Scott , Qianwa Liang
CPC classification number: A61K51/088 , G01N33/60 , G01N2333/96466
Abstract: The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
Abstract translation: 本申请涉及包含放射性标记和底物，包含放射性标记的成像剂的药物组合物的放射性标记的成像剂，以及使用放射性标记的成像剂的方法。 本申请进一步涉及制备放射性标记的成像剂的方法。 这些成像剂可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
-
公开(公告)号：US08691187B2
公开(公告)日：2014-04-08
申请号：US13035405
申请日：2011-02-25
Applicant: Anna Katrin Szardenings , Wei Zhang , Dhanalakshmi Kasi , Anjana Sinha , Umesh B. Gangadharmath , Joseph C. Walsh
Inventor： Anna Katrin Szardenings , Wei Zhang , Dhanalakshmi Kasi , Anjana Sinha , Umesh B. Gangadharmath , Joseph C. Walsh
IPC: A61K49/00
CPC classification number: C07D235/04 , A61K51/04 , C07B59/002 , C07D215/06 , C07D235/14 , C07D277/62 , C07D401/02 , C07D401/04 , C07D403/06 , C07D413/10 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
Abstract translation: 式（I） - （V）的成像剂和用于检测神经障碍的方法包括向需要的患者施用能够结合tau蛋白和＆amp;淀粉样蛋白肽的式（I） - （V）化合物。 本发明还涉及成像A＆bgr的方法; 和tau聚集体，其包括引入可检测量的包含放射性标记的式（I） - （V）化合物的药物制剂，并检测患者中与淀粉样蛋白沉积物和/或tau蛋白相关的标记化合物。 这些方法和组合使得临床前诊断和监测AD和其他神经障碍的进展。
-
公开(公告)号：US08420052B2
公开(公告)日：2013-04-16
申请号：US12509259
申请日：2009-07-24
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J. H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia , Vani P. Mocharla
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J. H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia , Vani P. Mocharla
CPC classification number: C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
Abstract: Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
Abstract translation: 本文提供了包含本文公开的式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。 根据本发明的淀粉样蛋白结合化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并且可以区分具有淀粉样沉积物的神经组织和正常神经组织。 本发明的淀粉样蛋白探针可用于检测和定量疾病中的淀粉样蛋白沉积物，包括例如唐氏综合症，家族性阿尔茨海默氏病。 在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。 本文还提供了允许化合物分布到脑组织中并对脑组织成像的方法，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或 有发展神经变性疾病的风险。
-
9.发明申请System, Device and Method for Preparing Tracers and Transferring Materials During Radiosynthesis 审中-公开在放射合成过程中制备示踪剂和转移材料的系统，装置和方法公开(公告)号：US20120283490A1
公开(公告)日：2012-11-08
申请号：US13445147
申请日：2012-04-12
Applicant: Umesh B. Gangadharmath , Joseph C. Walsh , Hartmuth C. Kolb , Ricardo Rodriguez , Arkadij M. Elizarov , Carroll Edward Ball
Inventor： Umesh B. Gangadharmath , Joseph C. Walsh , Hartmuth C. Kolb , Ricardo Rodriguez , Arkadij M. Elizarov , Carroll Edward Ball
CPC classification number: B01J19/004 , A61K51/0455 , A61K51/08 , A61K51/082 , B01J4/008 , C07B59/00 , Y10T137/86035
Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.
Abstract translation: 用于转移化学溶液并合成示踪剂的系统，装置和方法。 为了转移化学溶液，该系统包括主容器; 次级容器 与第一容器和次容器连通的第一线。 第一行有利于主容器和次容器之间的气体和/或液体的流动。 位于次级容器上游并且在主容器下游的阀调节第一管线内的流动; 与第二容器通信的第二行。 为了合成示踪剂，该系统包括具有放射性核素的溶液源。 第一容器具有示踪剂前体并与溶液源连通。
-
10.发明授权Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment 有权通过分子成像实现高治疗指标，引导靶向药物治疗公开(公告)号：US08293206B2
公开(公告)日：2012-10-23
申请号：US12455346
申请日：2009-06-01
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Dhanalakshmi Kasi , Umesh B. Gangadharmath , Peter J. H. Scott , Gang Chen , Vani P. Mocharla
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Dhanalakshmi Kasi , Umesh B. Gangadharmath , Peter J. H. Scott , Gang Chen , Vani P. Mocharla
CPC classification number: A61K51/088 , A61K51/082
Abstract: The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.
Abstract translation: 本公开提供了在需要这种治疗的患者中治疗癌症的方法，所述方法包括通过使用在肿瘤部位对癌症靶标特异的标记的生物标志物向患者进行分子成像程序来资格评估患者的治疗性治疗; 以及施用治疗有效量的包含连接于与抗体连接的化学治疗剂或靶向剂的靶向剂的化合物。 本发明的实施方案还包括使用这些方法的化合物和组合物。
-
-
-
-
-
-
-
-
-
Search Results
27
records
(took 0.024 seconds)
