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公开(公告)号：US07186409B2
公开(公告)日：2007-03-06
申请号：US09795675
申请日：2001-02-28
申请人： Evan Y. Snyder , Xandra O. Breakefield , Karen S. Aboody , Ulrich Herrlinger , William P. Lynch
发明人： Evan Y. Snyder , Xandra O. Breakefield , Karen S. Aboody , Ulrich Herrlinger , William P. Lynch
CPC分类号： C12N5/0623 , A61K31/4412 , A61K31/522 , A61K35/763 , A61K38/00 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2501/06 , C12N2501/999 , C12N2510/00 , C12N2710/16632 , C12N2710/16643 , C12N2710/16652 , Y02A50/473 , A61K2300/00
摘要： The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.
摘要翻译： 本发明基于令人惊奇的发现，即干细胞，更具体地说，神经干细胞可以遍及整个脑肿瘤迁移并跟踪转移性脑肿瘤细胞。 本发明提供了通过在受脑肿瘤影响的个体中施用基因工程神经干细胞来治疗脑肿瘤的方法。 本发明还提供了一种制备遗传工程化神经干细胞的方法和包含在药学上可接受的载体中的遗传工程化神经干细胞的组合物。
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公开(公告)号：US07655224B2
公开(公告)日：2010-02-02
申请号：US11546726
申请日：2006-10-12
申请人： Evan Y. Snyder , Xandra O. Breakefield , Karen S. Aboody , Ulrich Herrlinger , William P. Lynch
发明人： Evan Y. Snyder , Xandra O. Breakefield , Karen S. Aboody , Ulrich Herrlinger , William P. Lynch
CPC分类号： C12N5/0623 , A61K31/4412 , A61K31/522 , A61K35/763 , A61K38/00 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2501/06 , C12N2501/999 , C12N2510/00 , C12N2710/16632 , C12N2710/16643 , C12N2710/16652 , Y02A50/473 , A61K2300/00
摘要： The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.
摘要翻译： 本发明基于令人惊奇的发现，即干细胞，更具体地说，神经干细胞可以遍及整个脑肿瘤迁移并跟踪转移性脑肿瘤细胞。 本发明提供了通过在受脑肿瘤影响的个体中施用基因工程神经干细胞来治疗脑肿瘤的方法。 本发明还提供了一种制备遗传工程化神经干细胞的方法和包含在药学上可接受的载体中的遗传工程化神经干细胞的组合物。
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3.发明申请MICROGLIAL PRECURSOR CELLS FOR THE TREATMENT OF MALIGNANT NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM 审中-公开用于治疗中枢神经系统恶性肿瘤的微核前列腺细胞公开(公告)号：US20120183509A1
公开(公告)日：2012-07-19
申请号：US13266858
申请日：2010-04-28
IPC分类号： A61K35/30 , A61P35/00 , C12N5/0735 , C12N5/071
CPC分类号： A61K35/30 , A61K35/12 , C12N5/0622 , C12N2500/25 , C12N2500/32 , C12N2500/38 , C12N2500/44 , C12N2500/50 , C12N2501/22 , C12N2501/2303 , C12N2501/235 , C12N2501/58 , C12N2506/02
摘要： Microglial precursor cells for use in the treatment of malignant neoplasms of the central nervous system. A method of treating malignant neoplasms of the central nervous system comprising administering a pharmaceutically effective amount of microglial precursor cells to a subject in need thereof.
摘要翻译： 用于治疗中枢神经系统恶性肿瘤的小胶质前体细胞。 一种治疗中枢神经系统的恶性肿瘤的方法，包括向有需要的受试者施用药学有效量的小胶质前体细胞。
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公开(公告)号：US20070031391A1
公开(公告)日：2007-02-08
申请号：US11546726
申请日：2006-10-12
CPC分类号： C12N5/0623 , A61K31/4412 , A61K31/522 , A61K35/763 , A61K38/00 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2501/06 , C12N2501/999 , C12N2510/00 , C12N2710/16632 , C12N2710/16643 , C12N2710/16652 , Y02A50/473 , A61K2300/00
摘要： The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.
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