公开(公告)号：US20240180162A1

公开(公告)日：2024-06-06

申请号：US18269182

申请日：2021-12-22

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) ,  UNIVERSIDAD DE ZARAGOZA ,  FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO (ARAID) ,  FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA ARAGÓN (IIS ARAGÓN) ,  INSTITUTO ARAGONÉS DE CIENCIAS DE LA SALUD (IACS)

Inventor： Jose Miguel PALOMO CARMONA ,  Noelia LOSADA GARCÍA ,  Olga ABIAN FRANCO ,  Adrián VELÁZQUEZ CAMPOY ,  David ORTEGA ALARCÓN ,  Ana JIMÉNEZ ALESANCO ,  Laura CEBALLOS LAITA

IPC: A01N59/20 ,  A01N25/10 ,  A01N25/34 ,  A01P1/00

CPC classification number: A01N59/20 ,  A01N25/10 ,  A01N25/34 ,  A01P1/00

Abstract: A hybrid material includes a protein matrix and nanoparticles (NPs) of a type of Cu; a preparation method thereof; and the uses thereof. The hybrid material displays activity that inhibits SARS-CoV-2 proteins, which makes it usable as a biocidal agent and as an agent for coating and disinfecting materials selected from metal, paper, textiles and approved surgical face masks.

公开(公告)号：US20230340037A1

公开(公告)日：2023-10-26

申请号：US18005998

申请日：2021-07-21

Applicant: UNIVERSITAT AUTONOMA DE BARCELONA ,  UNIVERSIDAD DE ZARAGOZA

Inventor： Salvador VENTURA ZAMORA ,  Irantzu PALLARÈS GOITIZ ,  Jaime SANTOS SUÁREZ ,  Nunilo CREMADES CASASIN ,  Pablo José GRACIA GONZÁLEZ

IPC: C07K14/47 ,  G01N33/543 ,  G01N33/68

CPC classification number: C07K14/47 ,  G01N33/54373 ,  G01N33/6896 ,  A61K38/00

Abstract: The present invention generally relates to inhibitors of α-synuclein aggregation which are characterized by comprising an amphipathic α-helical peptide. The invention further relates to therapeutic and diagnostic uses of such inhibitors as well as corresponding plasmonic sensors, kits, and pharmaceutical compositions.

公开(公告)号：US20220084195A1

公开(公告)日：2022-03-17

申请号：US17424702

申请日：2020-01-17

Applicant: Fundación para la Investigatión del Hospital Universitario La Fe de la Comunidad Valenciana ,  QUIBIM, S.L. ,  UNIVERSIDAD DE ZARAGOZA

Inventor： Angel Alberich Bayarri ,  Fabio García Castro ,  Amadeo Ten Esteve ,  Luis Martí Bonmatí ,  María Ángeles Pérez Ansón

IPC: G06T7/00 ,  G06T7/136 ,  G06T7/13 ,  G06T7/60 ,  G16H30/40 ,  G06F16/538

Abstract: A method is disclosed for obtaining an image biomarker that quantifies the quality of the trabecular structure of bones. The method includes: retrieving high-resolution CT (Computed Tomography) and/or MRI (Magnetic Resonance Imaging) trabecular images from an image database; pre-processing and post-processing the high-resolution CT and/or MRI trabecular images and obtaining the unique image biomarker “QTS”. Pre-processing may include: calculating the region of interest “ROI”; calculating the bone fraction map; eliminating the partial volume effect; and, binarizing. Post-processing may include: skeletonisation and extraction of morphological and structural characteristics. Lastly, the unique image biomarker “QTS” is defined as: QTS=0.7137*Comp1+0.2863*Comp2.

公开(公告)号：US11224744B2

公开(公告)日：2022-01-18

申请号：US16867960

申请日：2020-05-06

Applicant: UNIVERSIDAD DE ZARAGOZA ,  UNIVERSITAT POMPEU FABRA ,  STERLING MEDICAL DEVICES

Inventor： Hector Sarnago Andía ,  Óscar Lucía Gil ,  José Miguel Burdío Pinilla ,  Alejandro Naval Pallarés ,  Antoni Ivorra Cano ,  Quim Castellví Fernández ,  Lawrence Bischoff

IPC: A61N1/32 ,  A61B18/12 ,  A61B18/00 ,  A23L3/32

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

公开(公告)号：US10673347B2

公开(公告)日：2020-06-02

申请号：US16065292

申请日：2016-12-22

Applicant: UNIVERSIDAD DE ZARAGOZA ,  UNIVERSITAT POMPEU FABRA

Inventor： Hector Sarnago Andía ,  Óscar Lucía Gil ,  José Miguel Burdío Pinilla ,  Alejandro Naval Pallarés ,  Antoni Ivorra Cano ,  Quim Castellví Fernández

IPC: H02M7/00 ,  H02J7/00 ,  H02J3/38 ,  H02M7/48 ,  A61N1/32 ,  H02M1/00 ,  A23L3/32 ,  A61B18/12 ,  A61B18/00

Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

公开(公告)号：US20150345860A1

公开(公告)日：2015-12-03

申请号：US14821608

申请日：2015-08-07

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) ,  UNIVERSIDAD DE ZARAGOZA ,  GWR INSTRUMENTS, INC.

Inventor： Conrado RILLO MILLÁN ,  Leticia TOCADO MARTÍNEZ ,  Richard C. REINEMAN ,  Richard J. WARBURTON

IPC: F25J1/02 ,  F25B9/14

Abstract: A system and a method for recovery and recycling of gases which are utilized in their liquid state as refrigerants in applications that require low temperatures, throughout various pressure ranges, from slightly above atmospheric pressures to pressures near the critical point for the particular gas. The system and method are based on closed-cycle cryocoolers and utilize the thermodynamic properties of the gas to achieve optimal liquefaction rates.

Abstract translation: 一种用于回收和再循环气体的系统和方法，其在液态中用作制冷剂，在需要低温的应用中，在各种压力范围内，从稍高于大气压力至特定气体临界点附近的压力。 该系统和方法基于闭环低温冷冻机，并利用气体的热力学性能来达到最佳液化率。

公开(公告)号：US20150293084A1

公开(公告)日：2015-10-15

申请号：US14417006

申请日：2013-07-26

Applicant: UNIVERSIDAD DE ZARAGOZA ,  FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

Inventor： Pablo Del Pino González De La Higuera ,  Beatriz Pelaz Garcia ,  Ester Polo Tobajas ,  Valeria Grazú Bonavía ,  Jesús Martínez De La Fuente ,  Victor Parro Garcia

IPC: G01N33/543 ,  G01N21/78

CPC classification number: G01N33/54386 ,  B82Y15/00 ,  G01N21/29 ,  G01N21/554 ,  G01N21/78 ,  G01N33/54326 ,  G01N33/54346 ,  G01N2021/786 ,  G01N2201/02 ,  G01N2201/06113 ,  Y10S977/954

Abstract: The present invention discloses a biosensor for visual detection of an analyte, based on the light to heat conversion properties of metal nanoparticles: the analyte is visually detected by the color change in the support areas (where the analyte is present), produced as a result of the heat generated by the metal nanoparticles where they are irradiated with an external light source. Use of said biosensor in a method for the detection of analytes is also claimed.

Abstract translation: 本发明公开了一种用于视觉检测分析物的生物传感器，其基于金属纳米颗粒的光热转换特性：通过在其中产生的支撑区域（存在分析物）的颜色变化来目视检测分析物。 的金属纳米粒子所产生的热量被外部光源照射。 还要求保护所述生物传感器在检测分析物的方法中的用途。

公开(公告)号：US20250011445A1

公开(公告)日：2025-01-09

申请号：US18030974

申请日：2021-10-08

Applicant: UCL BUSINESS LTD ,  UNIVERSITÄT ZU KÖLN ,  FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA ARAGÓN ,  FUNDACIÓN AGENCIA ARAGONESA PARA LA INVESTIGACIÓN Y EL DESARROLLO ,  UNIVERSIDAD DE ZARAGOZA

Inventor： Michael BERGMANN ,  Diego DE MIGUEL SAMANIEGO ,  Gianmaria LICCARDI ,  Julian PARDO JIMENO ,  Nieves PELTZER ,  Maria SECRIER ,  Lucia TARABORRELLI ,  Henning WALCZAK

IPC: C07K16/28 ,  A61K31/167 ,  A61K31/192 ,  A61K31/275 ,  A61K31/573 ,  A61K31/616 ,  A61K39/00 ,  A61K45/06 ,  A61P31/14 ,  C07K16/24

Abstract: The invention provides methods and means for the inhibition or neutralisation of death receptor/death ligand members of the tumour necrosis factor superfamil and TNF receptor superfamilies and/or the Toll-like receptor family, and/or NOD-like receptor and/or of the signalling induced via these receptors, preferably in combination with each other and/or with anti-inflammatory agents, in treating diseases such as Acute Respiratory Distress Syndrome (ARDS), such as that caused by airway-targeting viruses, such as SARS coronaviruses.

公开(公告)号：US11915420B2

公开(公告)日：2024-02-27

申请号：US17424702

申请日：2020-01-17

Applicant: Fundación para la Investigación del Hospital Universitario La Fe de la Comunidad Valenciana ,  QUIBIM, S.L. ,  UNIVERSIDAD DE ZARAGOZA

Inventor： Angel Alberich Bayarri ,  Fabio García Castro ,  Amadeo Ten Esteve ,  Luis Martí Bonmatí ,  María Ángeles Pérez Ansón

IPC: G06T7/00 ,  G06F16/538 ,  G06T7/13 ,  G06T7/136 ,  G06T7/60 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06F16/538 ,  G06T7/13 ,  G06T7/136 ,  G06T7/60 ,  G16H30/40 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/20044 ,  G06T2207/30008

Abstract: A method is disclosed for obtaining an image biomarker that quantifies the quality of the trabecular structure of bones. The method includes: retrieving high-resolution CT (Computed Tomography) and/or MRI (Magnetic Resonance Imaging) trabecular images from an image database; pre-processing and post-processing the high-resolution CT and/or MRI trabecular images and obtaining the unique image biomarker “QTS”. Pre-processing may include: calculating the region of interest “ROI”; calculating the bone fraction map; eliminating the partial volume effect; and, binarizing. Post-processing may include: skeletonisation and extraction of morphological and structural characteristics. Lastly, the unique image biomarker “QTS” is defined as:

QTS=0.7137*Comp1+0.2863*Comp2.

公开(公告)号：US20230330201A1

公开(公告)日：2023-10-19

申请号：US18309555

申请日：2023-04-28

Applicant: UNIVERSIDAD DE ZARAGOZA ,  BIOFABRI S.L.

Inventor： Carlos MARTÍN MONTAÑES ,  Juan Ignacio AGUILÓ ANENTO ,  Jesús Ángel GONZALO ASENSIO ,  Dessislava Vaneva MARINOVA ,  Santiago UGANDA MAÍZ ,  Esteban RODRÍGUEZ SÁNCHEZ ,  Eugenia PUENTES COLORADO ,  Concepción FERNÁNDEZ ÁLVAREZ-SANTULLANO

IPC: A61K39/04 ,  A61P37/04 ,  C12N1/20

CPC classification number: A61K39/04 ,  A61P37/04 ,  C12N1/20 ,  A61K2039/522

Abstract: The present invention refers to a freeze-dried composition consisting of an isolated microorganism belonging to the Mycobacterium tuberucolosis complex, preferably a M. tuberculos clinical isolate, more preferably M. tuberculosis clinical isolate, characterized in that it comprises a PhoP− phenotype by the inactivation by a genetic deletion of the Rv0757 gene and the deletion of a second gene, Rv2930 (fadD26), that prevents PDIM production (PDIM− phenotype) (the MTBVAC strain), and sucrose and sodium glutamate as stabilizers or excipients. The present invention further refers to the reconstituted composition obtained by adding water, preferably sterilized water for injection, to the freeze-dried composition as well as uses thereof, in particular for use as a prophylactic agent to those at risk of infection with M. tuberulosis or those at risk of developing tuberculosis disease, or as secondary agents for treating infected tuberculosis patients.