公开(公告)号：US09297815B2

公开(公告)日：2016-03-29

申请号：US12279418

申请日：2007-02-15

申请人： Ko Igami ,  Tomoharu Okazaki ,  Koichi Shinmyozu ,  Tomoko Ono ,  Fumio Furusaki

发明人： Ko Igami ,  Tomoharu Okazaki ,  Koichi Shinmyozu ,  Tomoko Ono ,  Fumio Furusaki

IPC分类号： C12Q1/37 ,  G01N33/86 ,  C12Q1/56

CPC分类号： G01N33/86 ,  C12Q1/56 ,  G01N2800/2871 ,  G01N2800/323

摘要： A method for detecting a condition in a patient with disturbance of consciousness, by analyzing an amount and/or activity of a von Willebrand factor-cleaving protease, and a kit for detecting a condition in a patient with disturbance of consciousness, comprising an antibody or a fragment thereof which specifically binds to a von Willebrand factor-cleaving protease, or a von Willebrand factor or a fragment thereof, are disclosed. Examples of the detection of a condition include a detection of cerebrovascular disease, a detection of arteriosclerotic vascular disease, and a detection or prediction of severity.

摘要翻译： 通过分析血管性血友病因子切割蛋白酶的量和/或活性以及用于检测患有意识障碍的患者的状况的试剂盒来检测患有意识紊乱的患者的状况的方法，所述方法包括抗体或 公开了其与血管性血友病因子切割蛋白酶或血管性血友病因子或其片段特异性结合的片段。 检测病症的实例包括脑血管疾病的检测，动脉硬化性血管疾病的检测以及严重性的检测或预测。

公开(公告)号：US20110143369A1

公开(公告)日：2011-06-16

申请号：US13030249

申请日：2011-02-18

申请人： Tomoko ONO ,  Shinichiro WATANABE ,  Fumio FURUSAKI ,  Ko IGAMI

发明人： Tomoko ONO ,  Shinichiro WATANABE ,  Fumio FURUSAKI ,  Ko IGAMI

IPC分类号： G01N33/573

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/755 ,  G01N2333/96486 ,  G01N2800/32 ,  Y10T436/106664

摘要： A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura (TTP), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) and the amount of vWF in a patient that has been diagnosed with DIC is disclosed. Using the method of the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be made from among patients diagnosed with DIC, which could not previously be distinguished on the basis of only clinical findings or known markers. Also disclosed is a kit for determining an appropriate treatment option, the kit comprising an antibody or a fragment thereof which specifically binds to ADAMTS13.

摘要翻译： 通过分析血管性血友病因子（vWF）的量和/或酶活性，确定已被诊断患有弥漫性血管内凝血（DIC）但可能具有血栓性血小板减少性紫癜（TTP）的患者的适当治疗选择的方法， 披露蛋白酶（ADAMTS13）和已诊断患有DIC的患者中的vWF量。 使用本发明的方法，可以从诊断为DIC的患者中进行血栓性血小板减少性紫癜（TTP）患者的鉴别诊断，以前不能仅基于临床发现或已知的标记来区分。 还公开了用于确定适当治疗选择的试剂盒，该试剂盒包含特异性结合ADAMTS13的抗体或其片段。

公开(公告)号：US20090075298A1

公开(公告)日：2009-03-19

申请号：US11915050

申请日：2006-05-19

申请人： Tomoko Ono ,  Minoru Ogura

发明人： Tomoko Ono ,  Minoru Ogura

IPC分类号： G01N33/573

CPC分类号： G01N33/585 ,  C12Q1/00 ,  C12Q1/34 ,  G01N33/573

摘要： A method of analyzing an enzyme, comprising (1) bringing a sample suspected of containing an enzyme to be analyzed into contact with an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, in a liquid, (2) separating the insoluble carrier from the liquid, and (3) analyzing a substrate or a fragment thereof which remains on the insoluble carrier and/or a fragment of the substrate which is released from the insoluble carrier into the liquid; and a kit for analyzing an enzyme, comprising at least an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, are disclosed.

摘要翻译： 一种分析酶的方法，包括：（1）将待测分析的样品与固定在不溶性载体上并可被酶切割的酶底物接触;（2） 从液体中分离不溶性载体，和（3）分析残留在不溶性载体和/或从不溶性载体释放到液体中的基质片段的底物或其片段; 以及用于分析酶的试剂盒，其至少包含固定在不溶性载体上并可被酶切割的酶底物。

公开(公告)号：US20090004673A1

公开(公告)日：2009-01-01

申请号：US12162879

申请日：2007-01-30

申请人： Tomoko Ono ,  Shinichiro Watanabe ,  Fumio Furusaki ,  Ko Igami

发明人： Tomoko Ono ,  Shinichiro Watanabe ,  Fumio Furusaki ,  Ko Igami

IPC分类号： G01N33/53 ,  C12Q1/56

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/755 ,  G01N2333/96486 ,  G01N2800/32 ,  Y10T436/106664

摘要： A method for determining a condition of disseminated intravascular coagulation (DIC), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) (preferably also the amount of vWF) in a patient suffering from DIC, and a kit for determining a condition of DIC, comprising an antibody or a fragment thereof which specifically binds to ADAMTS13, are disclosed. According to the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be carried out from among patients with DIC, which could not be distinguished on the basis of only clinical findings or known markers.

摘要翻译： 通过分析患有血管内血栓凝固（vICF）的von Willebrand因子（vWF） - 切割蛋白酶（ADAMTS13）（优选vWF的量）的量和/或酶活性来确定弥漫性血管内凝血（DIC）的状况的方法 DIC和用于确定DIC的条件的试剂盒，其包含特异性结合ADAMTS13的抗体或其片段。 根据本发明，可以从具有DIC的患者中进行血栓性血小板减少性紫癜（TTP）患者的鉴别诊断，其不能仅基于临床发现或已知标记来区分。

公开(公告)号：US06811865B2

公开(公告)日：2004-11-02

申请号：US10685805

申请日：2003-10-15

申请人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell ,  Faris Ohan ,  Prasad Shrikrishna Potnis ,  Michael Allen Daley ,  Sjon-Paul Lee Conyer

发明人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell ,  Faris Ohan ,  Prasad Shrikrishna Potnis ,  Michael Allen Daley ,  Sjon-Paul Lee Conyer

IPC分类号： B32B326

CPC分类号： C08J5/18 ,  A61F13/51462 ,  A61F2013/15552 ,  A61F2013/51419 ,  B32B27/12 ,  B32B27/32 ,  C08J2323/08 ,  C08L23/0815 ,  C08L2205/02 ,  C08L2314/02 ,  C08L2314/06 ,  Y10S428/91 ,  Y10T428/249953 ,  Y10T428/249986 ,  Y10T428/249987 ,  Y10T428/31909 ,  Y10T428/31938 ,  Y10T442/2336 ,  Y10T442/659 ,  Y10T442/673 ,  Y10T442/674 ,  Y10T442/678 ,  Y10T442/68 ,  Y10T442/681 ,  Y10T442/699 ,  C08L2666/04

摘要： A breathable, substantially liquid impermeable film and laminate are provided for use in a wide variety of personal care garments and protective garments. The film, and laminate containing the film, are extendible in a cross-direction to a stretched width which is at least 25% greater than an original, unstretched width. The film and laminate have a first water vapor transmission rate of at least about 500 grams/m2-24 hours coinciding with the unstretched width. The film and laminate have a much higher second water vapor transmission rate which is at least about 225% of the first water vapor transmission rate, and not less than about 4000 grams/m2-24 hours, coinciding with a stretched width that is only 25% greater than the stretched width.

摘要翻译： 提供透气的，基本上液体不可渗透的薄膜和层压材料用于各种个人护理服装和防护服。 含有该膜的膜和层压体可以在横向上延伸到比原始未拉伸宽度大至少25％的拉伸宽度。 膜和层压体具有与未拉伸宽度一致的至少约500克/平方米-224小时的第一水蒸气透过率。 膜和层压体具有比第一水蒸气透过率至少约225％高的第二水蒸汽透过率，并且不小于约4000克/平方米-24小时，与拉伸宽度一致 只比拉伸宽度大25％。

公开(公告)号：US06673980B1

公开(公告)日：2004-01-06

申请号：US09345359

申请日：1999-07-16

申请人： Eugenio Go Varona ,  Carol Ann Blaney ,  Audrie Tomoko Ono ,  Tamara Lee Mace

发明人： Eugenio Go Varona ,  Carol Ann Blaney ,  Audrie Tomoko Ono ,  Tamara Lee Mace

IPC分类号： A61F1320

CPC分类号： A61F13/51462

摘要： An absorbent article including a liquid-permeable top layer, an absorbent core layer, a breathable outer cover, and a creped inner nonwoven fibrous layer between the absorbent core and breathable outer cover. The creped inner nonwoven fibrous layer has a level of creping of about 5-75%, and is preferably permanently creped. The creped inner nonwoven fibrous layer serves as a dampness inhibitor which reduces or prevents perceived dampness on the external surface of the outer cover by lowering thermal conductivity between the absorbent core and the outer cover surface.

摘要翻译： 一种吸收性物品，其包括透液性顶层，吸收芯层，透气性外罩和位于吸收芯和透气外罩之间的起皱内层非织造纤维层。 起皱的内部非织造纤维层的起皱水平为约5-75％，优选为永久起皱。 起皱的内部非织造纤维层用作抑湿剂，其通过降低吸收芯和外盖表面之间的热导率来减少或防止外盖的外表面感觉到的湿度。

公开(公告)号：US06632212B1

公开(公告)日：2003-10-14

申请号：US09460490

申请日：1999-12-14

申请人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell

发明人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell

IPC分类号： A61F1315

CPC分类号： B32B27/12 ,  A61F13/51458 ,  A61F13/51462 ,  A61F13/51464 ,  A61F13/51466 ,  A61F13/5148 ,  A61F2013/51429

摘要： A breathable, substantially liquid impermeable laminate is provided that is permanently conformable to the contours of a wearer's body when used in a personal care absorbent article or a medical article. The laminate includes a breathable (preferably microporous) film and a fibrous nonwoven web. Both the film and the web are extendible in a cross direction to a width at least 25% greater than an original, unstretched width upon application of a stretching force. The web and the film, and the overall laminate, exhibit little or no retractive force once they have been stretched. A diaper or other garment can be constructed in undersized fashion using the laminate, permitting material savings. When the garment is worn, the laminate stretches only where needed to provide a substantially perfect fit on the wearer. The minimal retractive force avoids the skin marks, rashes, etc. that can result from elastic garments.

摘要翻译： 提供透气的，基本上液体不可渗透的层压体，其在用于个人护理吸收制品或医疗制品时永久地符合穿用者身体的轮廓。 层压体包括透气（优选微孔）膜和纤维非织造纤维网。 膜和纤维网都可以在横向上延伸到比施加拉伸力时原始的未拉伸宽度大至少25％的宽度。 幅材和薄膜以及整体层压板一旦被拉伸就显示很少或没有回缩力。 尿布或其他衣服可以使用层压板以较小尺寸的方式构造，从而节省材料。 当服装被磨损时，层压体仅在需要的地方延伸以提供对穿着者基本上完美的配合。 最小的回缩力避免了由弹性服装造成的皮肤痕迹，皮疹等。

公开(公告)号：US06579274B1

公开(公告)日：2003-06-17

申请号：US09651914

申请日：2000-08-31

申请人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell ,  Sjon-Paul Lee Conyer ,  Duane Girard Uitenbroek

发明人： Michael Tod Morman ,  Patricia Hsiaoyin Hwang ,  Audrie Tomoko Ono ,  Howard Martin Welch ,  Charles John Morell ,  Sjon-Paul Lee Conyer ,  Duane Girard Uitenbroek

IPC分类号： A61F1315

CPC分类号： B32B27/12 ,  A61F13/51458 ,  A61F13/51462 ,  A61F13/51464 ,  A61F13/51466 ,  A61F13/5148 ,  A61F2013/51429

摘要： A breathable, substantially liquid impermeable laminate is provided that is permanently conformable to the contours of a wearer's body when used in a personal care absorbent article or a medical article. The laminate includes a breathable (preferably microporous) film and a fibrous nonwoven web. Both the film and the web are extendible in a cross direction to a width at least 25% greater than an original, unstretched width upon application of a stretching force. The web and the film, and the overall laminate, exhibit little or no retractive force once they have been stretched. A diaper or other garment can be constructed in undersized fashion using the laminate, permitting material savings. When the garment is worn, the laminate stretches only where needed to provide a substantially perfect fit on the wearer. The minimal retractive force avoids the skin marks, rashes, etc. that can result from elastic garments.

摘要翻译： 提供透气的，基本上液体不可渗透的层压体，其在用于个人护理吸收制品或医疗制品时永久地符合穿用者身体的轮廓。 层压体包括透气（优选微孔）膜和纤维非织造纤维网。 膜和纤维网都可以在横向上延伸到比施加拉伸力时原始的未拉伸宽度大至少25％的宽度。 幅材和薄膜以及整体层压板一旦被拉伸就显示很少或没有回缩力。 尿布或其他衣服可以使用层压板以较小尺寸的方式构造，从而节省材料。 当服装被磨损时，层压体仅在需要的地方延伸以提供对穿着者基本上完美的配合。 最小的回缩力可以避免弹性衣服产生的皮肤痕迹，皮疹等。

公开(公告)号：US5913835A

公开(公告)日：1999-06-22

申请号：US720034

申请日：1996-09-27

申请人： Takayoshi Naoi ,  Yoichiro Sako ,  Minoru Ohzeki ,  Tomoko Ono ,  Mitsuyoshi Yamamoto

发明人： Takayoshi Naoi ,  Yoichiro Sako ,  Minoru Ohzeki ,  Tomoko Ono ,  Mitsuyoshi Yamamoto

IPC分类号： A61B5/00 ,  A61B5/22 ,  A61B5/103

CPC分类号： A61B5/415 ,  A61B5/00 ,  A61B5/225

摘要： In a voluntary-muscle strength measurement method and a muscular tonus state judgment method, the muscle strength of a voluntary muscle and the muscular tonus state can be measured accurately and objectively. The muscle strength of a voluntary muscle as the examiner pulls apart an O-ring shape formed with the thumb and another finger of subject's hand is measured with a first sensor placed at at least one point on the two fingers forming O-ring shape, and it is detected whether or not two fingers forming O-ring shape were pulled apart with a second sensor placed between two fingers forming O-ring shape, and the muscle strength at the time two fingers forming O-ring shape were pulled apart is measured by the detected outputs of the first and second sensors. Thereby, the O-ring test can be executed accurately and the muscle strength of a voluntary muscle can be measured with high reliability. The pressure is applied to an O-ring shape formed with the thumb and another finger of subject's hand from outside through a pressure sensor by a pressure applying unit, and the applied pressure is measured from the output of the pressure sensor. The muscle tonus state when the pressure is applied to the O-ring shape can be judged by the period of time in which the result of measurement is higher than the predetermined value.

摘要翻译： 在自愿肌肉力量测量方法和肌肉紧张状态判断方法中，可以准确和客观地测量自愿肌肉和肌肉紧张状态的肌肉力量。 当检查者拉开由拇指形成的O形圈形状时，自愿肌肉的肌肉力量被拉伸，并且用位于两个手指上的至少一个点上的第一传感器形成O形圈来测量被检者的手的另一个手指，以及 通过设置在形成O形环的两个指状物之间的第二传感器和两个手指形成O形环形状的拉伸时的肌肉强度被拉开来检测形成O形环的两个手指是否被拉开， 检测到的第一和第二传感器的输出。 因此，可以精确地执行O型圈试验，并且可以高度可靠地测量自愿肌肉的肌肉力量。 压力通过压力施加单元通过压力传感器从外部施加到由拇指和主体手的另一个手指形成的O形环，并且从压力传感器的输出测量施加的压力。 当压力施加到O形圈形状时的肌肉紧张状态可以通过测量结果高于预定值的时间段来判断。

公开(公告)号：US08759018B2

公开(公告)日：2014-06-24

申请号：US13030249

申请日：2011-02-18

申请人： Tomoko Ono ,  Shinichiro Watanabe ,  Fumio Furusaki ,  Ko Igami

发明人： Tomoko Ono ,  Shinichiro Watanabe ,  Fumio Furusaki ,  Ko Igami

IPC分类号： C12Q1/56 ,  G01N33/86

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893 ,  G01N2333/755 ,  G01N2333/96486 ,  G01N2800/32 ,  Y10T436/106664

摘要： A method for determining an appropriate treatment option for a patient who has been diagnosed with disseminated intravascular coagulation (DIC) but who may have thrombotic thrombocytopenic purpura (TTP), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) and the amount of vWF in a patient that has been diagnosed with DIC is disclosed. Using the method of the present invention, a differential diagnosis of patients with thrombotic thrombocytopenic purpura (TTP) can be made from among patients diagnosed with DIC, which could not previously be distinguished on the basis of only clinical findings or known markers. Also disclosed is a kit for determining an appropriate treatment option, the kit comprising an antibody or a fragment thereof which specifically binds to ADAMTS13.

摘要翻译： 通过分析血管性血友病因子（vWF）的量和/或酶活性，确定已被诊断患有弥漫性血管内凝血（DIC）但可能具有血栓性血小板减少性紫癜（TTP）的患者的适当治疗选择的方法， 披露蛋白酶（ADAMTS13）和已诊断患有DIC的患者中的vWF量。 使用本发明的方法，可以从诊断为DIC的患者中进行血栓性血小板减少性紫癜（TTP）患者的鉴别诊断，以前不能仅基于临床发现或已知的标记来区分。 还公开了用于确定适当治疗选择的试剂盒，该试剂盒包含特异性结合ADAMTS13的抗体或其片段。