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公开(公告)号：US20080064973A1
公开(公告)日：2008-03-13
申请号：US11930027
申请日：2007-10-30
IPC分类号： A61B5/0402
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.
摘要翻译： 公开了一种用于检测心脏事件（监护系统）的系统，其包括称为心脏切除器的植入装置，医师编程器和外部警报系统。 该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。 如果检测到心律失常，该系统还可以警告患者不太紧急的警报。 使用一个或多个检测算法，心脏扫描器可以检测患者的电描记图中的变化，其指示在发生后五分钟内的心脏事件，然后自动向患者发出事件发生。 为了提供此警告，监护系统包括在心脏保护器内和/或外部报警系统（外部报警装置）内的内部报警子系统（内部报警装置）。 如果将监护人系统放入心脏起搏器，该算法可以根据起搏器是否实际起搏心脏，对电图进行不同的分析。
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公开(公告)号：US20070249947A1
公开(公告)日：2007-10-25
申请号：US11812827
申请日：2007-06-22
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.
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公开(公告)号：US20070083253A1
公开(公告)日：2007-04-12
申请号：US11244777
申请日：2005-10-06
申请人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
发明人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/95 , A61M25/104 , A61M2025/1056 , A61M2025/1063
摘要： A thin-walled guide wire tube is fixedly and sealably attached to both a proximal section and a distal section of a balloon angioplasty catheter. A stent is co-axially mounted onto the inflatable balloon of the balloon angioplasty catheter. Because the guide wire tube forms an inner liner for the balloon angioplasty catheter, the fluid inflation lumen of the catheter is sealed so the inflation liquid that pressurizes the balloon will not leak as it would be if there were no “inner liner” and the balloon angioplasty catheter were attached to the guide wire itself. By not having a traditional inner shaft through which a conventional guide wire slides, the deflated balloon on which the stent is mounted can have a reduced diameter.
摘要翻译： 薄壁导丝管固定并密封地附接到球囊血管成形术导管的近端部分和远端部分。 支架同轴地安装在球囊血管成形术导管的可充气球囊上。 由于导丝管形成球囊血管成形术导管的内衬，导管的流体膨胀腔被密封，使得气囊加压的充气液体将不会像没有“内衬”那样泄漏，气球 血管成形术导管附着于导丝本身。 通过不具有传统导丝通过其传播的传统内轴，其上安装有支架的放气气球可以具有减小的直径。
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公开(公告)号：US20060286063A1
公开(公告)日：2006-12-21
申请号：US11176713
申请日：2005-07-07
申请人： Ronald Shebuski , Jack Luderer , Tim Fischell
发明人： Ronald Shebuski , Jack Luderer , Tim Fischell
IPC分类号： A61K38/17 , A61K31/787
CPC分类号： A61K38/02 , A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2013/00451 , A61K31/787 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/42 , A61L2300/432 , A61L2300/45 , A61L2300/602
摘要： The present invention describes various devices and methods wherein a cytostatic antiproliferative drug, either alone or in combination with other drugs, is placed between internal body tissues to prevent the formation of scar tissue and/or adhesions during healing of a wound or surgical site. Specific devices to achieve this administration include, but are not limited to, a permanent implant or a biodegradable material having an attached antiproliferative drug such as sirolimus. These antiproliferative drugs may be combined with other drugs including, but not limited to, antiplatelets, antithrombotics or anticoagulants. The present invention also contemplates methods to a reduce scar tissue and/or adhesions or adhesion formation at an anastomosis site. In particular, a cytostatic antiproliferative drug is administered to an arteriovenous shunt anastomoses in patients having end-stage renal disease.
摘要翻译： 本发明描述了各种装置和方法，其中单独或与其它药物组合的细胞生长抑制性抗增生药物被放置在体内组织之间，以防止伤口或手术部位愈合过程中形成瘢痕组织和/或粘连。 实现这种施用的具体装置包括但不限于具有附着的抗增殖药物如西罗莫司的永久性植入物或可生物降解材料。 这些抗增殖药物可以与其他药物组合，包括但不限于抗血小板，抗血栓药或抗凝血剂。 本发明还考虑了在吻合部位减少瘢痕组织和/或粘连或粘连形成的方法。 特别地，在具有终末期肾脏疾病的患者中，将静脉内抗增殖药物施用于动静脉分流吻合。
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公开(公告)号：US20050137483A1
公开(公告)日：2005-06-23
申请号：US10741141
申请日：2003-12-22
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61B5/04 , A61B5/0402 , A61B5/0452 , A61N1/04 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0452 , A61B5/04012 , A61N1/3702
摘要： The present invention is a system that utilizes optimized high pass or band pass filtering to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system uses either analog or digital high pass filtering having an electrogram voltage reduction of 6 dB at some frequency between 0.05 Hz and 1.0 Hz with less than 6 dB of attenuation at frequencies above 1.0 Hz. and more than 6 dB of attenuation for frequencies below 0.05 Hz. The optimized filter would include attenuation of electric power generation frequencies of either 50 Hz or 60 Hz to reduce electromagnetic interference. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.
摘要翻译： 本发明是一种利用优化的高通或带通滤波来提供由植入式心血管系统检测到的电描记图ST段变化的精确检测的系统，其中ST段改变指示冠状动脉缺血。 为了准确地检测电描记图ST段的变化，心脏扫描器系统使用模拟或数字高通滤波，其频率在0.05Hz至1.0Hz之间的某一频率处具有6dB的电压降，而在上述频率处具有小于6dB的衰减 1.0 Hz。 对于0.05Hz以下的频率，衰减超过6dB。 优化的滤波器将包括50Hz或60Hz的发电频率的衰减以减少电磁干扰。 该系统还包括植入和外部部分，如果感测到冠状动脉缺血则提供患者报警。
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公开(公告)号：US20070293778A1
公开(公告)日：2007-12-20
申请号：US11812826
申请日：2007-06-22
IPC分类号： A61B5/0432
CPC分类号： A61B5/0464 , A61B5/0006 , A61B5/0031 , A61B5/02455 , A61B5/04012 , A61B5/042 , A61B5/0432 , A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0472 , A61B5/686 , A61B5/746 , A61B5/7465 , A61N1/3702 , A61N1/37258 , A61N1/3756 , G16H40/67
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.
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7.发明申请公开(公告)号：US20070225788A1
公开(公告)日：2007-09-27
申请号：US11388161
申请日：2006-03-24
申请人： Robert Fischell , Tim Fischell , Malcolm Foster
发明人： Robert Fischell , Tim Fischell , Malcolm Foster
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/821
摘要： A first aspect of the present invention is an ostial stent positioner that has the form of a wire for most of its length and having a cylinder with expandable legs situated at the positioner's distal end. The cylinder with its attached wire acts as an introducer sheath to introduce a stent delivery system with a stent into the artery that is to be stented. A second aspect of the present invention is a method for accurately placing a stent at the ostium of an artery that would have an ostial stenosis. Examples of such arteries that have ostial stenoses are the right and left main coronary arteries, a saphenous vein graft as used in coronary bypass surgery and the renal arteries. Each of these arteries has an ostium situated at the aorta.
摘要翻译： 本发明的第一方面是一种口腔支架定位器，其具有大部分长度的线的形式，并且具有位于定位器的远端的具有可扩张腿的圆柱体。 具有附接线的圆柱体用作引导器护套以将具有支架的支架输送系统引入到要被支架的动脉中。 本发明的第二方面是一种将支架精确地放置在具有口腔狭窄的动脉的口处的方法。 具有口腔狭窄的这种动脉的实例是右冠状动脉和左主动脉冠状动脉，用于冠状动脉旁路手术的隐静脉移植物和肾动脉。 这些动脉中的每一个都具有位于主动脉的口。
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公开(公告)号：US20070110796A1
公开(公告)日：2007-05-17
申请号：US11585697
申请日：2006-10-24
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61K31/4745 , A61L15/00
CPC分类号： A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： Disclosed is a cytostatic drug attached to a sterile sheet that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This sheet onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL™ absorbable hemostat gauze-like sheet with an anti-proliferative drug such as sirolimus, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions or scar tissue. Another embodiment of this invention is a cytostatic drug attached to a sheet that is placed at the site of an anastamosis to decrease scar tissue formation from within the vessel at the site of the anastomosis.
摘要翻译： 公开了附着在无菌片上的细胞生长抑制药物，其被设计为放置在体内组织之间以防止术后粘连的形成，这些粘连真的是瘢痕组织形成。 药物放置在药物上或其中的片材可以是永久植入物，也可以是可生物降解的。 通过用诸如西罗莫司之类的抗增殖药物浸渍诸如Johnson＆Johnson SURGICEL TM可吸收止血纱布片之类的现有产品，可生物降解的药物浸渍网将作为细胞增殖的障碍，因此成为威慑 形成粘连或瘢痕组织。 本发明的另一个实施方案是连接到片材上的细胞生长抑制药物，其被放置在吻合部位以减少在吻合部位的血管内的瘢痕组织形成。
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公开(公告)号：US20070016089A1
公开(公告)日：2007-01-18
申请号：US11181969
申请日：2005-07-15
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Steven Johnson , Gregg Turi
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Steven Johnson , Gregg Turi
CPC分类号： A61B5/042 , A61B5/0031 , A61B5/02 , A61B5/02055 , A61B5/0452 , A61B5/1459
摘要： An implantable medical device is provided for subcutaneous implantation within a human being. The implantable medical device includes a pair of electrodes for sensing electrical signals from the human being's heart. Electronic circuitry having digital memory is provided with the electronic circuitry designed to record the electrical signals from the heart. The electronics of the electronic circuitry are housed in a case having a tapered shape to facilitate implantation and removal of the implantable medical device.
摘要翻译： 提供用于在人体内皮下植入的可植入医疗装置。 可植入医疗装置包括一对电极，用于感测来自人的心脏的电信号。 具有数字存储器的电子电路设置有被设计为记录来自心脏的电信号的电子电路。 电子电路的电子器件容纳在具有锥形形状的壳体中，以便于植入和移除可植入医疗装置。
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公开(公告)号：US20060224153A1
公开(公告)日：2006-10-05
申请号：US11098636
申请日：2005-04-05
申请人： Robert Fischell , Tim Fischell
发明人： Robert Fischell , Tim Fischell
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/02 , A61B2018/00214 , A61B2018/0022 , A61B2018/00232 , A61B2018/00375 , A61B2018/0212 , A61B2018/046
摘要： Disclosed are a means and method for rapidly and accurately positioning a toroidal balloon with its distal surface placed tightly against the endocardial surface of the left atrium at a location that is close to the ostium of a pulmonary vein. On the exterior surface of the toroidal balloon can be an electrically conducting wire that is capable of causing rf energy to be placed into the tissue of the left atrium so as to ablate that tissue to alter the conduction of aberrant electrical signals of the heart that are associated with atrial fibrillation. The toroidal balloon is wrapped circumferentially around a tapered balloon that is placed into the pulmonary vein. This system can be applied successively to at least one or as many as all four of the pulmonary veins that enter the left atrium to treat the patient's atrial fibrillation.
摘要翻译： 公开了一种用于快速且精确地定位环形球囊的手段和方法，其环向球囊的远侧表面紧邻肺静脉口部的位置紧靠左心房的心内膜表面。 在环形球囊的外表面上可以是导电线，其能够将rf能量放置在左心房的组织中，以便消融该组织以改变心脏的异常电信号的传导， 与心房颤动相关。 环形球囊围绕放置在肺静脉中的锥形球囊周向包裹。 该系统可以连续地应用于进入左心房的所有四个肺静脉中的至少一个或多个以治疗患者的心房颤动。
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