公开(公告)号：US07122057B2

公开(公告)日：2006-10-17

申请号：US10122129

申请日：2002-04-12

申请人： Heather Ann Beam ,  Thomas J. Bradbury ,  Kathleen D. Chesmel ,  Christopher M. Gaylo ,  Alfred Anthony Litwak ,  Qing Liu ,  Peter Albert Materna ,  Donald Monkhouse ,  Jennifer Patterson ,  Timothy J. Pryor ,  Sunil Saini ,  Henry Leon Surprenant ,  Chen-Chao Wang ,  Thomas George West ,  Jaedeok Yoo

发明人： Heather Ann Beam ,  Thomas J. Bradbury ,  Kathleen D. Chesmel ,  Christopher M. Gaylo ,  Alfred Anthony Litwak ,  Qing Liu ,  Peter Albert Materna ,  Donald Monkhouse ,  Jennifer Patterson ,  Timothy J. Pryor ,  Sunil Saini ,  Henry Leon Surprenant ,  Chen-Chao Wang ,  Thomas George West ,  Jaedeok Yoo

IPC分类号： A61F2/28

CPC分类号： A61L27/46 ,  A61F2/28 ,  A61F2002/30034 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30225 ,  A61F2002/30271 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0031 ,  A61F2310/00293 ,  A61L27/12 ,  A61L27/50 ,  A61L27/56 ,  A61L2430/02 ,  B33Y30/00 ,  B33Y80/00 ,  C04B28/34 ,  C04B35/447 ,  C04B35/634 ,  C04B35/638 ,  C04B38/06 ,  C04B2111/00181 ,  C04B2111/00836 ,  C04B2235/3212 ,  C04B2235/447 ,  C04B2235/5436 ,  C04B2235/6026 ,  C04B2235/616 ,  C04B2235/6567 ,  C04B2235/80 ,  C04B2235/96 ,  C04B35/00 ,  C04B38/0054 ,  C04B38/0074

摘要： An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.

摘要翻译： 用于作为骨替代物植入人体的工程再生生物结构（erb），其包括内部微观结构，介观结构和/或宏观结构以提供改善的骨生长，以及用于制备所述erb的方法。 在本发明的一个方面，生物结构具有可再吸收和不可再吸收的区域。 在本发明的另一方面，生物结构由羟基磷灰石，磷酸三钙和/或脱矿质骨构成。 在本发明的另一方面，多孔生物结构部分或全部注入可再吸收的，不可再吸收或可溶解的材料。

公开(公告)号：US06772026B2

公开(公告)日：2004-08-03

申请号：US09972832

申请日：2001-10-05

申请人： Thomas J. Bradbury ,  Christopher M. Gaylo ,  James A. Fairweather ,  Kathleen D. Chesmel ,  Peter A. Materna ,  Adolphe Youssef

发明人： Thomas J. Bradbury ,  Christopher M. Gaylo ,  James A. Fairweather ,  Kathleen D. Chesmel ,  Peter A. Materna ,  Adolphe Youssef

IPC分类号： G06F1900

CPC分类号： G05B19/4099 ,  A61C8/0006 ,  A61C13/0004 ,  A61F2/2803 ,  A61F2/30942 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2878 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30616 ,  A61F2002/30677 ,  A61F2002/30948 ,  A61F2002/30952 ,  A61F2002/30953 ,  A61F2002/30968 ,  A61F2210/0004 ,  A61F2250/0098 ,  A61F2310/00293 ,  A61K9/2095 ,  B29C64/135 ,  B33Y50/00 ,  B33Y80/00 ,  B65G2207/14 ,  G05B2219/35008 ,  G05B2219/35053 ,  G05B2219/35054 ,  G05B2219/35219 ,  G05B2219/35223 ,  G05B2219/45166 ,  G05B2219/45168 ,  G05B2219/49023 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3418 ,  G06F19/3456 ,  G06Q10/06 ,  G06Q30/0601 ,  G06Q50/22 ,  G16H10/60 ,  G16H50/50

摘要： The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.