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公开(公告)号：US06753310B1
公开(公告)日：2004-06-22
申请号：US09807278
申请日：2001-04-11
申请人： Naoto Oku , Koichi Ogino , Dai Ishikawa , Michinori Tanaka , Takao Taki
发明人： Naoto Oku , Koichi Ogino , Dai Ishikawa , Michinori Tanaka , Takao Taki
IPC分类号： A01N3718
CPC分类号： C07K5/0821 , A61K38/00 , C07K14/515 , C07K14/78
摘要： Angiogenesis-specific peptides which home selectively to neovascular tissues and comprise one of the peptides having the amino acid sequences shown in SEQ ID NOS: 1 to 17 and dendrimers thereof. These peptides are applicable to DDS preparations whereby drugs can be transported selectively to target cancer tissues and are useful as diagnostics for cancer, remedies for cancer, etc. which contribute to the improvement in the therapeutic effects on cancer.
摘要翻译： 血管生成特异性肽，其选择性地存在于新血管组织中并且包含具有SEQ ID NO：1至17所示的氨基酸序列的肽之一和其树枝状大分子。 这些肽适用于DDS制剂，其中药物可以选择性转运至靶癌组织，并且可用作癌症诊断，癌症治疗等，其有助于改善对癌症的治疗效果。
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公开(公告)号：US20130245239A1
公开(公告)日：2013-09-19
申请号：US13988157
申请日：2011-11-17
申请人： Takao Taki
发明人： Takao Taki
IPC分类号： C07K17/12
摘要： An objective is to provide fiber products having smooth texture and excellent softness, and in addition, excellent durability. A proteoglycan-bonded fiber product including a fiber to which a proteoglycan is covalently bonded is provided.
摘要翻译： 目的是提供具有光滑质地和优异柔软性的纤维制品，并且还具有优异的耐久性。 提供包含蛋白多糖共价键合的纤维的蛋白聚糖结合纤维制品。
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3.发明申请LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME 有权低分子量聚羟基丙酸衍生物和含有其的药物公开(公告)号：US20110281819A1
公开(公告)日：2011-11-17
申请号：US13143129
申请日：2010-02-01
申请人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
发明人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
IPC分类号： A61K31/728 , A61P11/06 , A61P17/00 , C08B37/08 , A61P37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and/or treatment of an allergic disease. An agent for prevention and/or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R′s each independently represent a hydrogen atom or an SO3H group etc.
摘要翻译： 用于预防和/或治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。 由以下通式（IA）或（IB）表示的预防和/或治疗选自传粉炎，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等
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4.发明申请EQUOL-CONTAINING EXTRACT, METHOD FOR PRODUCTION THEREOF, METHOD FOR EXTRACTION OF EQUOL, AND EQUOL-CONTAINING FOOD 有权含有等离子体提取物，其生产方法，提取方法和含有食品的方法公开(公告)号：US20110033564A1
公开(公告)日：2011-02-10
申请号：US12664298
申请日：2008-06-13
申请人： Michiaki Tominaga , Takao Taki , Toshiaki Matsumoto , Izumi Hanya , Takuma Imada , Kunihiko Matsuoka , Takuya Kishimoto , Yuko Uchiyama , Hiromasa Tsuneishi , Machiko Tsuji , Tania Valdes-Gonzalez , Kentaro Tadano , Kyoko Kameda
发明人： Michiaki Tominaga , Takao Taki , Toshiaki Matsumoto , Izumi Hanya , Takuma Imada , Kunihiko Matsuoka , Takuya Kishimoto , Yuko Uchiyama , Hiromasa Tsuneishi , Machiko Tsuji , Tania Valdes-Gonzalez , Kentaro Tadano , Kyoko Kameda
IPC分类号： A61K36/48 , C07D311/04 , A61P39/00
CPC分类号： A23L1/3002 , A21D2/368 , A23C9/1307 , A23C9/1315 , A23C9/1544 , A23C11/02 , A23C11/103 , A23C20/025 , A23F3/163 , A23F5/243 , A23L2/52 , A23L5/23 , A23L7/196 , A23L9/12 , A23L11/09 , A23L13/426 , A23L13/65 , A23L17/70 , A23L21/15 , A23L23/00 , A23L27/50 , A23L27/60 , A23L33/105 , A61K31/353 , A61K36/48
摘要： The present invention relates to an extract obtained by extracting useful components containing equol from an equol-containing fermented soybean hypocotyl, and to a method for producing the same.The present invention makes it possible to efficiently obtain useful components containing equol from the fermented soybean hypocotyl by subjecting an equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution as an extractant. The present invention reduces the content of saponin, which causes an unpleasant taste, by sequentially subjecting the equol-containing fermented soybean hypocotyl to extraction using an ethanol aqueous solution and ethanol, while efficiently extracting equol and glycitein.
摘要翻译： 本发明涉及通过从含有雌马酚的发酵大豆下胚轴中提取含有雌马酚的有用成分及其制造方法而获得的提取物。 通过使用乙醇水溶液作为萃取剂，使含有雌马酚的发酵大豆下胚轴进行提取，能够有效地从发酵大豆下胚轴中含有含有雌马酚的有用成分。 本发明通过依次使用乙醇水溶液和乙醇对含有雌马酚的发酵大豆下胚轴进行萃取，同时有效地提取雌马酚和黄豆黄素，从而降低了引起不愉快味道的皂素含量。
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公开(公告)号：US20060058226A1
公开(公告)日：2006-03-16
申请号：US10257950
申请日：2001-04-23
申请人： Dai Ishikawa , Koichi Ogino , Takao Taki
发明人： Dai Ishikawa , Koichi Ogino , Takao Taki
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K47/646 , A61K2039/6081 , C07K7/08 , C07K14/4748 , C07K14/70596 , C07K2319/00
摘要： GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of one or more amino acid residues and attaining specific binding to an anti-GD3 antibody; and medicinal compositions containing the same.
摘要翻译： GD3-含有由SEQ ID NO：1至4中任一个表示的氨基酸序列的模拟肽或由其衍生的氨基酸序列，通过取代，缺失，添加或插入一个或多个氨基酸残基并获得与 抗GD3抗体; 以及含有该组合物的药物组合物。
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公开(公告)号：US09539418B2
公开(公告)日：2017-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： A microneedle array is provided which has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin. The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译： 提供了一种微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）在皮肤表面层和/或角质层中不产生疼痛或出血的细度和柔韧性 微针的插入部位，（3）皮肤下的微针部分的溶解度或生物降解性。 微针阵列通过使用蛋白多糖作为基材形成微针来制造。
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公开(公告)号：US20130012882A1
公开(公告)日：2013-01-10
申请号：US13635813
申请日：2011-03-18
申请人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
发明人： Ying-shu Quan , Fumio Kamiyama , Takao Taki , Kazuyoshi Kawai , Tadayoshi Takemoto , Takuya Hamabuchi , Kazuhide Ohta
CPC分类号： A61M37/0015 , A61K8/981 , A61K8/987 , A61K9/0021 , A61K2800/87 , A61K2800/91 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61Q19/00 , A61Q19/08
摘要： An object of the present invention is to provide a novel microneedle array that has (1) the strength to withstand insertion into the skin surface layer and/or stratum corneum, (2) the fineness and flexibility to cause no pain or bleeding in the skin surface layer and/or stratum corneum at the insertion site of the microneedles, and (3) solubility or biodegradability of the microneedle portions under the skin.[Method for Achieving the Object]The microneedle array is produced by forming microneedles using proteoglycan as a base material.
摘要翻译： 本发明的目的是提供一种新颖的微针阵列，其具有（1）抵抗插入皮肤表面层和/或角质层的强度，（2）细度和柔韧性，使皮肤无疼痛或出血 表面层和/或角质层在微针的插入位置，和（3）皮肤下的微针部分的溶解度或生物降解性。 [实现对象的方法]微针阵列通过使用蛋白多糖作为基材形成微针来制造。
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公开(公告)号：US08017584B2
公开(公告)日：2011-09-13
申请号：US11943809
申请日：2007-11-21
申请人： Dai Ishikawa , Koichi Ogino , Takao Taki
发明人： Dai Ishikawa , Koichi Ogino , Takao Taki
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K47/646 , A61K2039/6081 , C07K7/08 , C07K14/4748 , C07K14/70596 , C07K2319/00
摘要： GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of one or more amino acid residues and attaining specific binding to an anti-GD3 antibody; and medicinal compositions containing the same.
摘要翻译： GD3-含有由SEQ ID NO：1至4中任一个表示的氨基酸序列的模拟肽或由其衍生的氨基酸序列，通过取代，缺失，添加或插入一个或多个氨基酸残基并获得与 抗GD3抗体; 以及含有该组合物的药物组合物。
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公开(公告)号：US20080125374A1
公开(公告)日：2008-05-29
申请号：US11943809
申请日：2007-11-21
申请人： Dai ISHIKAWA , Koichi OGINO , Takao TAKI
发明人： Dai ISHIKAWA , Koichi OGINO , Takao TAKI
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K47/646 , A61K2039/6081 , C07K7/08 , C07K14/4748 , C07K14/70596 , C07K2319/00
摘要： GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of one or more amino acid residues and attaining specific binding to an anti-GD3 antibody; and medicinal compositions containing the same.
摘要翻译： GD3-含有由SEQ ID NO：1至4中任一个表示的氨基酸序列的模拟肽或由其衍生的氨基酸序列，通过取代，缺失，添加或插入一个或多个氨基酸残基并获得与 抗GD3抗体; 以及含有该组合物的药物组合物。
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公开(公告)号：US07341994B2
公开(公告)日：2008-03-11
申请号：US10257950
申请日：2001-04-23
申请人： Dai Ishikawa , Koichi Ogino , Takao Taki
发明人： Dai Ishikawa , Koichi Ogino , Takao Taki
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K47/646 , A61K2039/6081 , C07K7/08 , C07K14/4748 , C07K14/70596 , C07K2319/00
摘要： GD3-Mimetic peptides which contain an amino acid sequence represented by any of SEQ ID NOS: 1 to 4 or an amino acid sequence derived therefrom by substitution, deletion, addition, or insertion of one or more amino acid residues and attaining specific binding to an anti-GD3 antibody; and medicinal compositions containing the same.
摘要翻译： GD3-含有由SEQ ID NO：1至4中任一个表示的氨基酸序列的模拟肽或由其衍生的氨基酸序列，通过取代，缺失，添加或插入一个或多个氨基酸残基并获得与 抗GD3抗体; 以及含有该组合物的药物组合物。
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