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1.发明申请NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开新型碳水化合物人体细胞组成及其分析及其改良方法公开(公告)号：US20100145032A1
公开(公告)日：2010-06-10
申请号：US12523628
申请日：2008-01-18
Applicant: Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
Inventor： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
IPC: C12Q1/02 , C12N5/074 , C12P21/00 , C07K14/435
CPC classification number: G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
Abstract translation: 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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公开(公告)号：US20090317834A1
公开(公告)日：2009-12-24
申请号：US12306774
申请日：2007-06-29
Applicant: Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Juhani Saarinen , Taina Jaatinen , Milla Mikkola , Suvi Natunen
Inventor： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Juhani Saarinen , Taina Jaatinen , Milla Mikkola , Suvi Natunen
IPC: G01N33/567 , C12N5/06
CPC classification number: G01N33/6848 , C08B37/0006 , C08B37/006 , C12N5/0606 , G01N33/56966 , G01N2400/10
Abstract: The invention describes novel compositions of glycans, glycomes, from human embryonic stem cells, and especially novel subcompositions of the glycomes with specific monosaccharide compositions and glycan structures. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore, the invention is directed to stem cells carrying the modified glycomes on their surfaces. The glycomes are preferably analysed by profiling methods able to detect reproducibly and quantitatively numerous individual glycan structures at the same time. The most preferred type of the profile is a mass spectrometric profile. The invention specifically revealed novel target structures and is especially directed to the development of reagents recognizing the structures.
Abstract translation: 本发明描述了来自人胚胎干细胞的聚糖，糖原的新组合物，特别是具有特异性单糖组成和聚糖结构的糖链的新型亚组合物。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。 优选地通过能够同时检测可重复地和定量地检测许多个体聚糖结构的分析方法来分析糖分。 轮廓的最优选类型是质谱分布。 本发明特别揭示了新颖的靶结构，特别涉及识别结构的试剂的开发。
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3.发明授权Carbohydrate profile compositions from human cells and methods for analysis and modification thereof 有权来自人细胞的碳水化合物曲线组合物及其分析和修饰方法公开(公告)号：US08691774B2
公开(公告)日：2014-04-08
申请号：US11988564
申请日：2006-07-11
Applicant: Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
Inventor： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
IPC: G01N33/577 , G01N33/574
CPC classification number: C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
Abstract translation: 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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公开(公告)号：US08440457B2
公开(公告)日：2013-05-14
申请号：US11921563
申请日：2006-06-06
Applicant: Taina Jaatinen , Heidi Anderson , Jukka Partanen , Jarmo Laine , Tero Satomaa , Jari Natunen , Maria Blomqvist
Inventor： Taina Jaatinen , Heidi Anderson , Jukka Partanen , Jarmo Laine , Tero Satomaa , Jari Natunen , Maria Blomqvist
IPC: C12N5/07 , C12N5/071 , C12N5/078 , C12N5/0789
CPC classification number: G01N33/5308 , G01N33/5002 , G01N33/56966
Abstract: The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with structure NeuNAcα3Gal, and at least one of said markers is a mRNA marker related to glycoproteins and/or glycosynthase proteins. The invention also relates to method for purification of cord blood cell population and to a complete cell population from cord blood purified by said method.
Abstract translation: 本发明涉及一种细胞群体分型方法，包括检测所述细胞群体中存在或不存在至少两种生物学标记的步骤，其中所述标记物中的至少一种是细胞表面标志物，其是唾液酸化N - 结构NeuNAcalpha3Gal的糖基标记，并且所述标记中的至少一个是与糖蛋白和/或糖基转移酶蛋白相关的mRNA标记。 本发明还涉及用于通过所述方法纯化的脐血细胞群体和来自脐血的完整细胞群的纯化方法。
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5.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 有权来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20100055710A1
公开(公告)日：2010-03-04
申请号：US11988564
申请日：2006-07-11
Applicant: Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
Inventor： Tero Satomaa , Jari Natunen , Jarmo Laine , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola , Heidi Anderson
CPC classification number: C12N5/0665 , C08B37/00 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/59 , G01N33/56966 , G01N33/574 , G01N33/57469 , G01N33/577 , G01N2400/10 , G01N2400/38 , G01N2560/00
Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
Abstract translation: 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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Patent Agency Ranking
6.发明申请NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开来自人类细胞的新型碳水化合物及其分析和改性方法公开(公告)号：US20100028913A1
公开(公告)日：2010-02-04
申请号：US12523586
申请日：2008-01-18
Applicant: Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
Inventor： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
IPC: G01N33/569 , G01N33/53 , G01N33/577
CPC classification number: G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
Abstract: The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
Abstract translation: 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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公开(公告)号：US20090148839A1
公开(公告)日：2009-06-11
申请号：US11988418
申请日：2006-07-07
Applicant: Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
Inventor： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC classification number: C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
Abstract: The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
Abstract translation: 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20110217724A1
公开(公告)日：2011-09-08
申请号：US13123818
申请日：2009-10-15
Applicant: Taina Jaatinen , Seppo Meri , Sami Junnikkala , Jarmo Laine , Jukka Partanen
Inventor： Taina Jaatinen , Seppo Meri , Sami Junnikkala , Jarmo Laine , Jukka Partanen
CPC classification number: A61L27/3834 , A61K9/0024 , A61K35/28 , A61K38/1709 , A61K38/177 , A61L27/505
Abstract: Provided is a method for protecting stem cells in a clinical graft against destruction induced by the complement system by adding to the graft at least one factor capable of inhibiting the complement. Also provided is a method for protecting stem cells in a clinical graft against destruction induced by the complement system using a factor capable of inhibiting the complement.
Abstract translation: 本发明提供一种通过向移植物添加至少一种能够抑制补体的因子来保护临床移植物中的干细胞免受补体系统诱导的破坏的方法。 还提供了一种用于使用能够抑制补体的因子来保护临床移植物中的干细胞免受补体系统诱导的破坏的方法。
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公开(公告)号：US20100055678A1
公开(公告)日：2010-03-04
申请号：US11921563
申请日：2006-06-06
Applicant: Taina Jaatinen , Heidi Hemmoranta , Jukka Partanen , Jamo Laine , Tero Satomaa , Jari Natunen , Maria Blomqvist
Inventor： Taina Jaatinen , Heidi Hemmoranta , Jukka Partanen , Jamo Laine , Tero Satomaa , Jari Natunen , Maria Blomqvist
CPC classification number: G01N33/5308 , G01N33/5002 , G01N33/56966
Abstract: The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with structure NeuNAcα3Gal, and at least one of said markers is a mRNA marker related to glycoproteins and/or glycosynthase proteins. The invention also relates to method for purification of cord blood cell population and to a complete cell population from cord blood purified by said method.
Abstract translation: 本发明涉及一种细胞群体分型方法，包括检测所述细胞群体中存在或不存在至少两种生物学标记的步骤，其中所述标记物中的至少一种是细胞表面标志物，其是唾液酸化N - 结构NeuNAcα3Gal的糖苷标记，并且所述标记中的至少一个是与糖蛋白和/或糖基转移酶蛋白相关的mRNA标记。 本发明还涉及用于通过所述方法纯化的脐血细胞群体和来自脐血的完整细胞群的纯化方法。
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10.发明申请Novel Carbohydrate Profile Compositions From Human Cells and Methods for Analysis and Modification Thereof 审中-公开来自人类细胞的新型碳水化合物组成及其分析和修饰方法公开(公告)号：US20090162938A1
公开(公告)日：2009-06-25
申请号：US12084626
申请日：2006-11-08
Applicant: Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
Inventor： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Taina Jaatinen , Ulla Impola , Milla Mikkola
CPC classification number: G01N33/5073 , G01N2400/12 , G01N2400/38
Abstract: The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.
Abstract translation: 本发明描述了从人多潜能干细胞生产聚糖，糖原的新组合物的方法。 本发明进一步涉及用于修改糖尿病和分析糖尿病和修饰的糖尿病的方法。 此外，本发明涉及在其表面上携带修饰的糖基的干细胞。
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