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1.发明申请公开(公告)号：US20230123762A1
公开(公告)日：2023-04-20
申请号：US17904038
申请日：2021-02-11
申请人： TENZA, INC.
发明人： Anik DEBNATH
IPC分类号： C12N15/74 , C12Q1/02 , A61P1/00 , A61P7/04 , A61K35/747
摘要： Provided herein are embodiments directed to heme-responsive promoter sequences, heme-responsive repressor systems which may be used as probiotic bacteria and as bio-therapeutics, such probiotic bacteria and bio-therapeutics are described in methods of detecting bleeding in a mucosal environment, diagnosing in vivo bleeding in a mucosal environment, and treating in vivo bleeding in a mucosal environment.
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2.发明公开公开(公告)号：US20240166694A1
公开(公告)日：2024-05-23
申请号：US18281388
申请日：2022-03-18
申请人： TENZA, INC.
发明人： Anik Debnath , Devon Stork
CPC分类号： C07K14/001 , A01N63/22 , A61K35/742 , C12N1/20 , C12N15/75 , C12P21/02 , C07K2319/02 , C12R2001/085
摘要： Provided herein are pre-protein signal peptides that direct secretion of expressed payload proteins in Bacillus bacteria and methods of their use in therapeutic and agriculture settings. The disclosed pre-protein signal peptides may be used with any payload protein to increase secretion thereof and therefore increase yield of the payload protein.
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公开(公告)号：US20240174722A1
公开(公告)日：2024-05-30
申请号：US18281117
申请日：2022-03-11
申请人： TENZA, INC.
发明人： Anik Debnath , Ameet Shetty
IPC分类号： C07K14/395 , A61K36/064 , A61K38/00 , C12N1/18 , C12R1/685 , C12R1/84 , C12R1/87 , C12R1/885
CPC分类号： C07K14/395 , A61K36/064 , C12N1/185 , A61K38/00 , C07K2319/02 , C12R2001/685 , C12R2001/84 , C12R2001/87 , C12R2001/885
摘要： Provided herein are signal peptides that direct secretion of expressed payload proteins in yeast. Methods of using the signal peptides for therapeutic and non-therapeutic utilities are also provided. Compositions comprising yeast comprising the signal peptides and methods of using said yeast comprising the signal peptides for therapeutic and non-therapeutic utilities are also provided. Methods to design and generate the disclosed signal peptides are also provided.
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