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1.发明授权公开(公告)号：US11967666B2
公开(公告)日：2024-04-23
申请号：US16978641
申请日：2018-03-07
发明人： Sönke Fündling , Frederik Steib , Andreas Waag
CPC分类号： H01L33/387 , H01L27/153 , H01L33/0062 , H01L33/0075 , H01L33/30 , H01L33/32 , H01L33/44 , H01L2933/0016 , H01L2933/0025
摘要： A semiconductor device for emitting electromagnetic radiation, and to a method of producing the same, which can be used as a semiconductor-based, structured light source. The semiconductor device comprises a layer stack structure composed of an n-doped layer, an active layer and a p-doped layer, as well as a connection structure comprising conductor layers and at least one insulator layer, the conductor layers being arranged, parallel to and spaced apart from one another, along a first direction that is parallel to the active layer of the layer stack structure, and at least one insulator layer being arranged between at least two conductor layers, one or more conductor layers being electrically connected to the p-doped layer of the layer stack structure.
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公开(公告)号：US20230183375A1
公开(公告)日：2023-06-15
申请号：US17925061
申请日：2021-05-14
CPC分类号： C07K16/40 , A61K9/0014 , A61K9/06 , A61K47/34 , C07K2317/622 , A61K2039/54
摘要： The present invention relates to human tissue kallikrein 7 (KLK7) selective inhibitor compounds, combinations including these compounds, process to obtain the referred compounds, and methods of using the same. The present invention belongs to the field of chemistry, pharmacology and medicine.
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公开(公告)号：US20230076676A1
公开(公告)日：2023-03-09
申请号：US17798432
申请日：2021-02-11
发明人： Olga CASALS GUILLEN , Nicolai MARKIEWICZ , Cristian FÀBREGA GALLEGO , Andreas Hans Wilhelm WAAG , Juan Daniel PRADES GARCÍA
摘要： The sensing arrangement (1), comprising:—a sensing area (10), for accommodating a sensing substance (20) selected for experimenting an optical response as a response of an external stimulus;—a light emitter (11), for emitting light towards said sensing area (10);—a light receiver (12), for receiving a light from said sensing area (10);—a substrate (13) having a first substrate surface (131) and a second substrate surface (132); wherein, said light emitter (11) comprise a first LED (110) and said light receiver (12) comprise a second LED (120), both LEDs (110, 120) formed on said first substrate surface (131); and said sensing arrangement (1) further comprises a trench (14), formed between said first LED (110) and said second LED (120).
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公开(公告)号：US11789250B2
公开(公告)日：2023-10-17
申请号：US17087754
申请日：2020-11-03
发明人： Andreas Waag , Daria Bezshlyakh , Hendrik Spende , Jan Gülink
CPC分类号： G02B21/365 , G01N21/6458 , G02B21/16 , G02B27/30 , G01N2021/6463
摘要： An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources. Thus, the examination region is irradiated by a light pattern that has been demagnified with respect to the light pattern emitted.
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公开(公告)号：US20220133796A1
公开(公告)日：2022-05-05
申请号：US17494610
申请日：2021-10-05
发明人： Elmar Jäckel , Fatih Noyan , Michael Hust
摘要： A fusion protein for use in the treatment of HvG disease in a patient having received a transplant, for use in suppressing the host's immune response directed against the transplant. The fusion protein is adapted for use in suppressing the immune rejection of a transplant which contains or expresses HLA-A*02 or SLA-01*0401 in a recipient patient who is negative for HLA-A*02 or SLA-01*0401, i.e. the patient prior to transplantation does not express HLA-A*02 or SLA-01*0401. The fusion protein is a chimeric antigen receptor (CAR), which upon expression in regulatory T-cells (Treg) causes a specific suppressor activity of the regulatory T-cells in the presence of HLA-A*02 or SLA-01*0401.
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公开(公告)号：US20210353733A1
公开(公告)日：2021-11-18
申请号：US17277572
申请日：2018-09-19
申请人： Technische Universität Braunschweig , Max-Planck-Gesellschaft Zur Förderung Der Wissenschaft E.V. , Medizinische Hochschule Hannover
发明人： Viola Fühner , Michael Hust , Stefan Dübel , Felix Löffler , Ralf Gerhard
摘要： The invention provides an antigenic peptide comprising an epitope for use in the prevention and/or treatment of an infection by C. difficile, e.g. for use as a vaccine in the prevention and/or treatment of an infection by C. difficile, and protective antibodies directed against the epitope.
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公开(公告)号：US20200283508A1
公开(公告)日：2020-09-10
申请号：US16879272
申请日：2020-05-20
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , UNIVERSITY MEDICAL CENTER UTRECHT, THE NETHERLANDS , Università degli Studi di Pavia , Technische Universität Braunschweig
发明人： Ya-Ping Ko , Magnus Hook , Suzan HM Rooijakkers , Livia Visai , Federico Bertoglio , Michael Hust , Doris Meier
IPC分类号： C07K16/12 , A61K47/68 , A61K39/085
摘要： The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.
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公开(公告)号：US20150332878A1
公开(公告)日：2015-11-19
申请号：US14652971
申请日：2013-12-20
发明人： Vladimir Ermel , Michael Kurrat
IPC分类号： H01H33/664
CPC分类号： H01H9/36 , H01H33/08 , H01H33/10 , H01H33/164 , H01H33/20 , H01H33/596 , H01H33/664 , H01H33/6647
摘要： The invention relates to a power circuit breaker that is suitable for switching electrical voltages. The power circuit breaker according to the invention comprises two main electrodes, to each of which a respective pole of the voltage to be switched can be connected. During the switching process, at least one of said main electrodes follows a switching path. The power circuit breaker is characterized in that secondary electrodes are additionally provided, which protrude into the vicinity of the switching path and are designed and arranged in such a way that arcs can be produced (a) between the main electrodes and the secondary electrodes and (b) between the individual secondary electrodes during the switching process. The power circuit breaker according to the invention can be advantageously used in vehicles and in ultra-high-voltage AC and HVDC (high-voltage direct current) transmission systems and causes arcs to be extinguished as early as possible during the switching process.
摘要翻译： 本发明涉及一种适用于切换电压的电源断路器。 根据本发明的电源断路器包括两个主电极，每个主电极可以连接要切换的电压的相应极点。 在切换过程中，至少一个所述主电极跟随切换路径。 电源断路器的特征在于，另外设置有二次电极，其突出到开关路径附近，并且被设计和布置成使得可以在主电极和次电极之间产生电弧（a）和（ b）在切换过程中各个次级电极之间。 根据本发明的电力断路器可以有利地用于车辆和超高压AC和HVDC（高压直流）传输系统中，并且在切换过程中尽可能早地熄灭电弧。
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公开(公告)号：US20150198674A1
公开(公告)日：2015-07-16
申请号：US14415449
申请日：2013-07-16
CPC分类号： G01R31/389 , G01R31/3646 , G01R31/367 , G01R31/3842 , G01R31/392 , H01M10/4257 , H01M10/48 , H01M10/486 , H01M2010/4271 , H02J7/0047 , H02J2007/005
摘要： The present invention relates to a method and a suitable apparatus for determining the state of a rechargeable battery and for checking contact resistances in a battery system. According to the invention, an impedance curve is determined using signals at different frequencies and a value for an area, which results from the impedance curve, is then calculated from a predetermined threshold value and an x axis. The value for the area is a measure of the ageing of the battery. A control signal is generated on the basis thereof. In one preferred embodiment, said control signal is used to drive a signaling apparatus and thus to present the state of the battery to a user. The present invention can be used, for example, in motor vehicles that are electrically driven.
摘要翻译： 本发明涉及一种用于确定可再充电电池的状态并用于检查电池系统中的接触电阻的方法和合适的装置。 根据本发明，使用不同频率的信号确定阻抗曲线，然后从预定的阈值和x轴计算由阻抗曲线得到的面积的值。 该区域的值是电池老化的量度。 基于此产生控制信号。 在一个优选实施例中，所述控制信号用于驱动信令装置，从而将电池的状态呈现给用户。 本发明可以用于例如电动车辆。
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10.发明公开公开(公告)号：US20240227714A1
公开(公告)日：2024-07-11
申请号：US18558631
申请日：2022-05-03
发明人： Naveen SHIRUR , Christian BIRKNER , Roman HENZE , Thomas DESERNO
IPC分类号： B60R21/015
CPC分类号： B60R21/01508 , B60R21/01516
摘要： The invention refers to a crash monitoring system (10) for a vehicle (50) equipped with an airbag (52). The system (10) comprises an occupant monitoring system (12) configured for providing a mass value corresponding to a mass of the head (42) of an occupant (40) of the vehicle (50); an airbag pressure sensor (14) configured for providing a pressure value corresponding to a gas pressure within the airbag (52) of the vehicle (50); an airbag contact sensor (16) configured for providing a contact area value corresponding to a contact area at which the head (42) of the occupant (40) of the vehicle (50) contacts the airbag (52) of the vehicle (50); and a processing unit (18) configured for providing an acceleration value corresponding to an acceleration of the head (42) of the occupant (40) of the vehicle (50) based on the mass value, the pressure value and the contact area value. The invention further refers to an airbag system and a vehicle comprising such an occupant monitoring system and to a corresponding method of generating an acceleration value corresponding to an acceleration of the head (42) of an occupant (40) of a vehicle (50) in a crash situation.
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