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    Compositions and the Use of Fibrinogen Binding Motif Presence in EFB and COA for Vaccine Against Staphylococcus Aureus and Drug Delivery
    1.
    发明申请
    Compositions and the Use of Fibrinogen Binding Motif Presence in EFB and COA for Vaccine Against Staphylococcus Aureus and Drug Delivery 审中-公开
    组合物和纤维蛋白原结合基因在EFB和COA中的应用用于疫苗对金黄色葡萄球菌和药物递送

    公开(公告)号：US20160235832A1

    公开(公告)日：2016-08-18

    申请号：US15029896

    申请日：2014-10-15

    申请人： THE TEXAS A&M UNIVERSITY SYSTEM ,  UNIVERSITY MEDICAL CENTER UTRECHT, THE NETHERLANDS

    发明人： Ya-Ping Ko ,  Magnus Hook ,  Suzan HM Rooijakkers ,  Mary Beth Browning

    IPC分类号： A61K39/085 ,  G01N33/577 ,  G01N33/68 ,  C07K16/12 ,  C07K14/31

    CPC分类号： A61K39/085 ,  A61K2039/55516 ,  C07K14/31 ,  C07K16/1271 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/40 ,  G01N33/577 ,  G01N33/6854 ,  G01N2500/02

    摘要： The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.

    摘要翻译： 本公开提供了包括疫苗，单克隆抗体，多克隆抗体，细胞外纤维蛋白原结合蛋白（Efb）的嵌合分子和包含至少部分修饰的N末端区域的靶向药物递送药物组合物的方法和组合物，至少一部分 修饰的C末端区域或两者，其中所述修饰的细胞外纤维蛋白原结合蛋白导致抑制纤维蛋白原结合，C3结合或两者或向受试者施用药学上有效量的药学上可接受的赋形剂中的疫苗，其包含 修饰的细胞外纤维蛋白原结合蛋白，其包含修饰的N末端区域的至少一部分，修饰的C末端区域的至少一部分或两者，其中所述修饰的细胞外纤维蛋白原结合蛋白导致不能屏蔽葡萄球菌细菌免受识别 吞噬受体。