公开(公告)号：US20240034727A1

公开(公告)日：2024-02-01

申请号：US18254686

申请日：2021-12-01

Applicant: STINGRAY THERAPEUTICS, INC.

Inventor： Srinivas Rao Kasibhatla ,  Sunil Sharma ,  Mohan Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D413/12 ,  C07D233/90 ,  C07D403/04

CPC classification number: C07D413/12 ,  C07D233/90 ,  C07D403/04

Abstract: Compounds having activity as inhibitors of ENPP1 are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer, or prodrug thereof, wherein L, R1, R2a, R2b, R2c, R2d, R2e and n are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating disorders associated with ENPP1, including uncontrolled cellular proliferation, cancer and virial or bacterial infections in a mammal.

公开(公告)号：US11591313B2

公开(公告)日：2023-02-28

申请号：US17168109

申请日：2021-02-04

Applicant: Stingray Therapeutics, Inc.

Inventor： Srinivas Rao Kasibhatla ,  Raman Kumar Kalakuntla ,  Alexis Weston ,  Trason Thode ,  Sunil Sharma ,  Mohan R. Kaadige

IPC: C07D403/04 ,  A61P35/00 ,  C07D239/88 ,  C07D239/94 ,  C07D239/74 ,  C07D403/14 ,  C07D487/08 ,  C07D401/14 ,  C07D401/04 ,  C07D215/54

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

公开(公告)号：US11407729B2

公开(公告)日：2022-08-09

申请号：US16821098

申请日：2020-03-17

Applicant: Stingray Therapeutics, Inc.

Inventor： Hariprasad Vankayalapati ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston

IPC: C07D401/04 ,  C07D413/14 ,  A61P35/00 ,  C07D401/14

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

公开(公告)号：US20200299258A1

公开(公告)日：2020-09-24

申请号：US16821098

申请日：2020-03-17

Applicant: Stingray Therapeutics, Inc.

Inventor： Hariprasad Vankayalapati ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston

IPC: C07D401/04 ,  C07D413/14 ,  C07D401/14

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

公开(公告)号：US10689376B2

公开(公告)日：2020-06-23

申请号：US16047915

申请日：2018-07-27

Applicant: Stingray Therapeutics, Inc. ,  The University of Utah

Inventor： Hariprasad Vankayalapati ,  Xiaohui Liu ,  Gurusankar Ramamoorthy ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D471/04

Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

公开(公告)号：US20200039979A1

公开(公告)日：2020-02-06

申请号：US16529693

申请日：2019-08-01

Applicant: Stingray Therapeutics, Inc.

Inventor： Hariprasad Vankayalapati ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D471/04 ,  A61P35/00 ,  A61K9/00 ,  A61K47/26 ,  A61K47/38 ,  A61K47/36 ,  A61K47/12 ,  A61K47/02

Abstract: Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

公开(公告)号：US12152015B2

公开(公告)日：2024-11-26

申请号：US18109705

申请日：2023-02-14

Applicant: Stingray Therapeutics, Inc.

Inventor： Srinivas Rao Kasibhatla ,  Raman Kumar Kalakuntla ,  Alexis Weston ,  Trason Thode ,  Sunil Sharma ,  Mohan R. Kaadige

IPC: C07D403/04 ,  A61P35/00 ,  C07D215/54 ,  C07D239/74 ,  C07D239/88 ,  C07D239/94 ,  C07D401/04 ,  C07D401/14 ,  C07D403/14 ,  C07D487/08

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

公开(公告)号：US11142524B2

公开(公告)日：2021-10-12

申请号：US16529693

申请日：2019-08-01

Applicant: Stingray Therapeutics, Inc.

Inventor： Hariprasad Vankayalapati ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D471/04 ,  A61P35/00 ,  A61K9/00 ,  A61K47/26 ,  A61K47/02 ,  A61K47/36 ,  A61K47/12 ,  A61K47/38

Abstract: Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

公开(公告)号：US20210253556A1

公开(公告)日：2021-08-19

申请号：US17168109

申请日：2021-02-04

Applicant: Stingray Therapeutics, Inc.

Inventor： Srinivas Rao Kasibhatla ,  Raman Kumar Kalakuntla ,  Alexis Weston ,  Trason Thode ,  Sunil Sharma ,  Mohan R. Kaadige

IPC: C07D403/04 ,  A61P35/00 ,  C07D239/88 ,  C07D239/94 ,  C07D215/54 ,  C07D403/14 ,  C07D487/08 ,  C07D401/14 ,  C07D401/04 ,  C07D239/74

Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

公开(公告)号：US20190031655A1

公开(公告)日：2019-01-31

申请号：US16047915

申请日：2018-07-27

Applicant: Stingray Therapeutics, Inc. ,  The University of Utah

Inventor： Hariprasad Vankayalapati ,  Xiaohui Liu ,  Gurusankar Ramamoorthy ,  Sunil Sharma ,  Mohan Rao Kaadige ,  Alexis Weston ,  Trason Thode

IPC: C07D471/04

Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.