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1.发明授权公开(公告)号：US12152015B2
公开(公告)日：2024-11-26
申请号：US18109705
申请日：2023-02-14
Applicant: Stingray Therapeutics, Inc.
Inventor： Srinivas Rao Kasibhatla , Raman Kumar Kalakuntla , Alexis Weston , Trason Thode , Sunil Sharma , Mohan R. Kaadige
IPC: C07D403/04 , A61P35/00 , C07D215/54 , C07D239/74 , C07D239/88 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/14 , C07D487/08
Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).
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2.发明申请
公开(公告)号：US20210253556A1
公开(公告)日：2021-08-19
申请号：US17168109
申请日：2021-02-04
Applicant: Stingray Therapeutics, Inc.
Inventor： Srinivas Rao Kasibhatla , Raman Kumar Kalakuntla , Alexis Weston , Trason Thode , Sunil Sharma , Mohan R. Kaadige
IPC: C07D403/04 , A61P35/00 , C07D239/88 , C07D239/94 , C07D215/54 , C07D403/14 , C07D487/08 , C07D401/14 , C07D401/04 , C07D239/74
Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).
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3.发明公开
公开(公告)号：US20230183212A1
公开(公告)日：2023-06-15
申请号：US18109705
申请日：2023-02-14
Applicant: Stingray Therapeutics, Inc.
Inventor： Srinivas Rao Kasibhatla , Raman Kumar Kalakuntla , Alexis Weston , Trason Thode , Sunil Sharma , Mohan R. Kaadige
IPC: C07D403/04 , A61P35/00 , C07D239/88 , C07D239/94 , C07D239/74 , C07D403/14 , C07D487/08 , C07D401/14 , C07D401/04 , C07D215/54
CPC classification number: C07D403/04 , A61P35/00 , C07D239/88 , C07D239/94 , C07D239/74 , C07D403/14 , C07D487/08 , C07D401/14 , C07D401/04 , C07D215/54
Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).
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4.发明授权
公开(公告)号：US11591313B2
公开(公告)日：2023-02-28
申请号：US17168109
申请日：2021-02-04
Applicant: Stingray Therapeutics, Inc.
Inventor： Srinivas Rao Kasibhatla , Raman Kumar Kalakuntla , Alexis Weston , Trason Thode , Sunil Sharma , Mohan R. Kaadige
IPC: C07D403/04 , A61P35/00 , C07D239/88 , C07D239/94 , C07D239/74 , C07D403/14 , C07D487/08 , C07D401/14 , C07D401/04 , C07D215/54
Abstract: Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).
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公开(公告)号：US20240034727A1
公开(公告)日：2024-02-01
申请号：US18254686
申请日：2021-12-01
Applicant: STINGRAY THERAPEUTICS, INC.
Inventor： Srinivas Rao Kasibhatla , Sunil Sharma , Mohan Kaadige , Alexis Weston , Trason Thode
IPC: C07D413/12 , C07D233/90 , C07D403/04
CPC classification number: C07D413/12 , C07D233/90 , C07D403/04
Abstract: Compounds having activity as inhibitors of ENPP1 are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer, or prodrug thereof, wherein L, R1, R2a, R2b, R2c, R2d, R2e and n are as defined herein. This disclosure provides methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds, and methods for treating disorders associated with ENPP1, including uncontrolled cellular proliferation, cancer and virial or bacterial infections in a mammal.
