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![Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics](data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='200' height='200' viewBox='0 0 200 200'%3E%3Crect width='100%25' height='100%25' fill='%23eee'%3E%3C/rect%3E%3Ctext x='50%25' y='50%25' dominant-baseline='middle' text-anchor='middle' fill='%23333333' font-family='Helvetica' font-size='20' font-weight='bold'%3ENo Pic%3C/text%3E%3C/svg%3E)
公开(公告)号：US20190031655A1
公开(公告)日：2019-01-31
申请号：US16047915
申请日：2018-07-27
Applicant: Stingray Therapeutics, Inc. , The University of Utah
Inventor： Hariprasad Vankayalapati , Xiaohui Liu , Gurusankar Ramamoorthy , Sunil Sharma , Mohan Rao Kaadige , Alexis Weston , Trason Thode
IPC: C07D471/04
Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
![Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics](/docs/US/2019-01-31/US20190031655A1/abs.jpg.600x600.jpg)
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公开(公告)号：US10689376B2
公开(公告)日：2020-06-23
申请号：US16047915
申请日：2018-07-27
Applicant: Stingray Therapeutics, Inc. , The University of Utah
Inventor： Hariprasad Vankayalapati , Xiaohui Liu , Gurusankar Ramamoorthy , Sunil Sharma , Mohan Rao Kaadige , Alexis Weston , Trason Thode
IPC: C07D471/04
Abstract: Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.
![Substituted-3H-imidazo [4,5-c] pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) and stimulator for interferon genes (STING) modulators as cancer immunotherapeutics](/docs/US/2020-06-23/US10689376B2/abs.jpg.600x600.jpg)
