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公开(公告)号：US20240198244A1
公开(公告)日：2024-06-20
申请号：US18521561
申请日：2023-11-28
申请人： Stefan Roos
发明人： Stefan Roos
IPC分类号： A63G31/02
CPC分类号： A63G31/02
摘要： An apparatus (1) serves for the amusement of persons. It has a fixed frame (2), on which a pivoting frame (3) is supported in an articulated manner about an approximately horizontal pivot axis (4). This pivoting frame (3) can be pivoted between an essentially vertical, closed position and a pivoted, exposed position. A net (5) or mesh is retained in the pivoting frame (3), and the person lies thereon in the exposed position. The pivoting frame (3) can be adjusted by means of at least one threaded spindle (8) with a self-locking thread pitch.
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2.发明授权公开(公告)号：US08617537B2
公开(公告)日：2013-12-31
申请号：US12481530
申请日：2009-06-09
申请人： Stefan Roos
发明人： Stefan Roos
IPC分类号： A61K35/74
摘要： Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterin in the bacterial cell during preservation and storage. In particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterin, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
摘要翻译： 通过在制备细胞培养物期间加入甘油和其他物质并在保存和储存期间将产生的罗伊氏菌素保持在细菌细胞中来控制罗伊氏乳杆菌产生罗伊氏乳杆菌生产机器的方法。 特别地，本发明涉及装载有罗伊氏菌素的大量罗伊氏乳杆菌的制造，以及这种负载细菌用于诸如预防和治疗疾病，食品应用等的应用。
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公开(公告)号：US6100388A
公开(公告)日：2000-08-08
申请号：US39773
申请日：1998-03-16
申请人： Ivan Casas , Hans Jonsson , Bo Mollstam , Stefan Roos
发明人： Ivan Casas , Hans Jonsson , Bo Mollstam , Stefan Roos
CPC分类号： C07K14/4727 , C07K14/335 , C12N15/746 , A61K39/00 , C07K2319/00
摘要： Live vaccines and methods for preparing the vaccines useful in protecting a host from infection by a pathogenic microorganism are provided. Vaccines are prepared from live Lactobacillus cells which have been transformed using DNA technology to express heterologous antigens of pathogenic microorganisms or other suitable biological material. Genes encoding antigenic determinants pathogenic in the mammalian gastrointestinal tract are inserted into expression cassettes and fused with genes encoding an aggregation factor and/or a mucin binding factor. The inserted genes are shown to transform L. reuteri cells. The aggregation enhancing and mucin binding genes have been isolated and sequenced. The vaccine can be ingested orally in a pharmaceutical carrier or in milk products.
摘要翻译： 提供了用于制备用于保护宿主免受致病微生物感染的疫苗的活疫苗和方法。 使用DNA技术转化的活乳杆菌细胞制备疫苗以表达病原微生物或其他合适的生物材料的异源抗原。 编码在哺乳动物胃肠道中致病的抗原决定簇的基因插入表达盒中，并与编码聚集因子和/或粘蛋白结合因子的基因融合。 插入的基因显示转化罗伊氏乳杆菌细胞。 聚集增强和粘蛋白结合基因已被分离和测序。 该疫苗可以在药物载体或乳制品中口服摄取。
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4.发明授权公开(公告)号：US08945534B2
公开(公告)日：2015-02-03
申请号：US14070814
申请日：2013-11-04
申请人： Stefan Roos
发明人： Stefan Roos
摘要： Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterin in the bacterial cell during preservation and storage. In particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterin, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
摘要翻译： 通过在制备细胞培养物期间加入甘油和其他物质并在保存和储存期间将产生的罗伊氏菌素保持在细菌细胞中来控制罗伊氏乳杆菌产生罗伊氏乳杆菌生产机器的方法。 特别地，本发明涉及装载有罗伊氏菌素的大量罗伊氏乳杆菌的制造，以及这种负载细菌用于诸如预防和治疗疾病，食品应用等的应用。
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5.发明申请公开(公告)号：US20140057992A1
公开(公告)日：2014-02-27
申请号：US14070814
申请日：2013-11-04
申请人： Stefan Roos
发明人： Stefan Roos
摘要： Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterm in the bacterial cell during preservation and storage, in particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterm, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
摘要翻译： 通过在制备细胞培养物期间加入甘油和其他物质并在保存和储存期间将生产的再发用菌保持在细菌细胞中来控制罗伊氏乳杆菌产生罗伊氏乳杆菌生产机器的方法，特别是本发明涉及制造 大量含有reuterm的罗伊氏乳杆菌，以及使用这种负载的细菌用于诸如预防和治疗疾病，用于食品应用等的应用。
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6.发明申请公开(公告)号：US20150104852A1
公开(公告)日：2015-04-16
申请号：US14577122
申请日：2014-12-19
申请人： Stefan Roos
发明人： Stefan Roos
摘要： Methods for the control led activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterin in the bacterial cell during preservation and storage. In particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterin, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
摘要翻译： 控制方法通过在制备细胞培养过程中加入甘油和其他物质并在保存和储存期间将产生的罗伊氏菌素保持在细菌细胞中，导致罗伊氏乳杆菌的罗伊氏菌素生产机制的活化。 特别地，本发明涉及装载有罗伊氏菌素的大量罗伊氏乳杆菌的制造，以及这种负载细菌用于诸如预防和治疗疾病，食品应用等的应用。
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7.发明申请公开(公告)号：US20120263696A1
公开(公告)日：2012-10-18
申请号：US13400735
申请日：2012-02-21
申请人： Stefan ROOS
发明人： Stefan ROOS
IPC分类号： A61K35/74 , A61K31/732 , A61K31/7004
CPC分类号： A61K35/747 , A23L33/135 , A23V2002/00 , A23Y2220/71 , A61K31/7004 , A61K31/732 , A61K2300/00 , A23V2200/32 , A23V2200/3204 , A23V2250/28 , A23V2250/5072 , A23V2250/624
摘要： The present invention relates generally to enhanced activity of certain probiotics. The increased efficacy is achieved by using certain substrate components that indirectly supply the probiotics with a specific source of energy. The substrate components are specifically designed to stimulate 1,2-propanediol production.
摘要翻译： 本发明一般涉及某些益生菌的活性增强。 通过使用间接提供具有特定能量来源的益生菌的某些底物组分来实现增加的功效。 底物组分是专门设计用于刺激1,2-丙二醇生产的。
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8.发明申请公开(公告)号：US20090304656A1
公开(公告)日：2009-12-10
申请号：US12481530
申请日：2009-06-09
申请人： Stefan Roos
发明人： Stefan Roos
摘要： Methods for the controlled activation of the reuterin-production machinery of Lactobacillus reuteri by adding glycerol and other substances during the manufacture of cell-cultures and keeping the produced reuterin in the bacterial cell during preservation and storage. In particular this invention relates to the manufacture of large amounts of L. reuteri that are loaded with reuterin, and the use of such loaded bacteria for applications such as prevention and treatment of diseases, for food applications and the like.
摘要翻译： 通过在制备细胞培养物期间加入甘油和其他物质并在保存和储存期间将产生的罗伊氏菌素保持在细菌细胞中来控制罗伊氏乳杆菌产生罗伊氏乳杆菌生产机器的方法。 特别地，本发明涉及装载有罗伊氏菌素的大量罗伊氏乳杆菌的制造，以及这种负载细菌用于诸如预防和治疗疾病，食品应用等的应用。
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9.发明申请Selection of lactic acid bacteria enhancing the immune response against Streptococcus pneumoniae 审中-公开选择增强对肺炎链球菌的免疫应答的乳酸菌公开(公告)号：US20050220777A1
公开(公告)日：2005-10-06
申请号：US10991891
申请日：2004-11-18
申请人： Stefan Roos , Torun Wall , Hans Jonsson , Bo Mollstam
发明人： Stefan Roos , Torun Wall , Hans Jonsson , Bo Mollstam
CPC分类号： A61K39/092 , A61K35/747 , A61K2035/11 , A61K2039/52 , C12N1/20
摘要： A method of selection of lactic acid bacteria for providing a method of protecting humans against Streptococcus pneumoniae infections by selecting a lactic acid bacterial strain (LAB) naturally carrying genes coding for proteins similar to the PspC, choline binding protein of S. pneumoniae so that the selected LAB can be used in various products for oral and nasal administration to humans as immune enhancers against S. pneumoniae, and products containing specifically selected LAB that naturally carry genes coding for proteins similar to PcpC binding protein of S. pneumoniae as oral and nasal immune enhancers for humans.
摘要翻译： 选择乳酸菌的方法，通过选择天然携带编码类似于肺炎链球菌的PspC，胆碱结合蛋白的蛋白质的基因的乳酸菌株（LAB），从而提供一种保护人免受肺炎链球菌感染的方法， 选择的LAB可用于各种用于人类口服和鼻内给药的产品，作为针对肺炎链球菌的免疫增强剂，以及含有特异性选择的LAB的产品，其天然携带编码类似于肺炎链球菌的PcpC结合蛋白的蛋白质的基因作为口服和鼻免疫 人的增强剂。
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