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    Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances
    1.
    发明授权
    Antibiotics SF-1771 substance and SF-1771-B substance as well as the production of these substances 失效
    抗生素SF-1771物质和SF-1771-B物质以及这些物质的生产

    公开(公告)号：US4169140A

    公开(公告)日：1979-09-25

    申请号：US736143

    申请日：1976-10-27

    申请人： Kazunori Ohba ,  Takashi Shomura ,  Hiroshi Watanabe ,  Kunikazu Totsukawa ,  Michio Kojima ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inoue ,  Taro Niida

    发明人： Kazunori Ohba ,  Takashi Shomura ,  Hiroshi Watanabe ,  Kunikazu Totsukawa ,  Michio Kojima ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inoue ,  Taro Niida

    IPC分类号： A61K35/74 ,  A61P31/04 ,  C07G11/00 ,  C12P1/06 ,  C12R1/465 ,  A61K35/00

    CPC分类号： C12P1/06

    摘要： A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomyces toyocaensis SF-1771, in a liquid culture medium under aerobic conditions. This antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing antibiotic which shows antibacterial activity against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a toxicity lower than SF-1771 substance.

    摘要翻译： 通过在有氧条件下在液体培养基中培养新的菌株Streptomyces toyocaensis SF-1771来生产新的抗生素SF-1771物质。 通过用合成吸附剂树脂处理肉汤滤液以吸附活性化合物并用含水醇或丙酮水溶液洗脱树脂，然后进行色谱纯化，从发酵液中分离出该抗生素。 SF-1771物质是对大肠杆菌，伤寒沙门氏菌，铜绿假单胞菌，金黄色葡萄球菌和枯草芽孢杆菌具有抗菌活性的含铜抗生素。 通过用硫化氢，碱金属硫化物或铜螯合剂处理从SF-1771物质中除去铜成分得到不含铜成分的SF-1771-B物质，其抗菌活性高于但低于SF的毒性 -1771物质。

    "> 9,3
    5.
    发明授权
    9,3",4"-Triacyl ester of the antibiotic SF-837 M.sub.1 substance and the production thereof 失效
    9,3 {41,4 {41-抗生素SF-837M {HD 1 {B物质及其制备的三

    公开(公告)号：US4017607A

    公开(公告)日：1977-04-12

    申请号：US597188

    申请日：1975-07-18

    申请人： Shigeharo Inouye ,  Shoji Omoto ,  Katsuyoshi Iwamatsu ,  Takashi Tsuruoka ,  Taro Niida ,  Toyoaki Kawasaki

    发明人： Shigeharo Inouye ,  Shoji Omoto ,  Katsuyoshi Iwamatsu ,  Takashi Tsuruoka ,  Taro Niida ,  Toyoaki Kawasaki

    IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： As new compounds are provided 9,3",4"-trialkanoyl SF-837 M.sub.1 substances which have therapeutically useful antibacterial activity and do not show any objectionable long-lasting bitter taste upon its oral administration. These 9,3",4"-trialkanoyl SF-837 M.sub.1 substances may be prepared from SF-837 substance, 9,2',3"-tri-acetyl SF-837 M.sub.1 substance, 9,2'-di-acetyl SF-837 substance, 9-propionyl SF-837 substance or 9,2'-dipropionyl SF-837 substance by acylating the latter with an alkanoic acid anhydride at 50.degree.-120.degree. C to produce the corresponding 9,2',3",4"-tetra-alkanoyl SF-837 M.sub.1 substance and occasionally the 9,18,2',3",4"-penta-alkanoyl SF-837 M.sub.1 substance, with involving the shift of the 4"-alkanoyl group to the 3"-hydroxyl group. Partial and selective hydrolysis of the 9,2',3",4"-tetra-alkanoyl SF-837 M.sub.1 substance and/or the 9,18,2',3",4"-penta-alkanoyl SF-837 M.sub.1 substance so produced gives the desired 9,3",4"-tri-alkanoyl SF-837 M.sub.1 substance.

    摘要翻译： 当新化合物被提供具有治疗上有用的抗菌活性的9,3“，4” - 三烷酰基SF-837M1物质，并且在其口服给药时不显示任何令人不快的持久苦味。 这些9,3“，4” - 三烷酰基SF-837 M1物质可以由SF-837物质，9,2'，3“ - 三乙酰基SF-837M1物质，9,2'-二 - 乙酰基SF-837物质，9-丙酰基SF-837物质或9,2'-二丙酰基SF-837物质，通过用烷基酸酐在50°-120℃下酰化后者，产生相应的9,2' 3“，4” - 四烷酰基SF-837 M1物质，偶尔有9,18,2'，3“，4” - 五烷酰基SF-837 M1物质，涉及4 “ - 烷酰基与3” - 羟基。 9,2'，3“，4” - 四烷酰基SF-837 M1物质和/或9,18,2'，3“，”4“ - 五烷酰基SF- 837如此生产的M1物质得到所需的9,3“，”4“ - 三烷酰基SF-837 M1物质。

    Dust collector guide for joint planer
    8.
    发明授权
    Dust collector guide for joint planer 失效
    联合刨床除尘器导轨

    公开(公告)号：US4932449A

    公开(公告)日：1990-06-12

    申请号：US406391

    申请日：1989-09-12

    申请人： Shoji Omoto

    发明人： Shoji Omoto

    IPC分类号： B27G3/00 ,  B23Q11/00 ,  B27G19/00

    CPC分类号： B23Q11/0042 ,  Y02P70/171 ,  Y10T83/207

    摘要： A joint planer has a chute for guiding chips resulting from a planing operation to a dust collector guide. The chute is attached to a vertically-movable table near its work surface and extends to the upper edge of the dust collector guide, which is below the planer cutting barrel. The lower end of the chute slides up and down against the edge of the dust collector guide with movement of the vertical table, thereby maintaining a closed path from the surface to the dust collector guide.

    摘要翻译： 联合刨床具有用于将由刨削操作产生的碎屑引导至集尘器引导件的滑槽。 滑槽在其工作表面附近附着到可垂直移动的工作台上，并延伸到集尘器导轨的上边缘，该上部边缘位于刨床切割筒的下方。 滑槽的下端随着垂直工作台的移动而相对于集尘器引导件的边缘上下滑动，从而保持从表面到集尘器引导件的封闭路径。

    Process for the production of a cephamycin derivative
    9.
    发明授权
    Process for the production of a cephamycin derivative 失效
    生产头孢霉素衍生物的方法

    公开(公告)号：US4302580A

    公开(公告)日：1981-11-24

    申请号：US185594

    申请日：1980-09-09

    申请人： Katsuyoshi Iwamatsu ,  Jiro Itoh ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inouye

    发明人： Katsuyoshi Iwamatsu ,  Jiro Itoh ,  Shoji Omoto ,  Takashi Tsuruoka ,  Shigeharu Inouye

    IPC分类号： C07D501/04 ,  C07D501/36 ,  C07D501/57 ,  C12P35/08

    CPC分类号： C12P35/08

    摘要： A chemotherapeutic, antibacterial agent, 7.beta.-[(2D-2-amino-2-carboxy)ethylthioacetamido]-7.alpha.-methoxy-3-[(1-methyl-1H-tetrazole-5-yl)thiomethyl]-3-cephem-4-carboxylic acid is produced economically and efficiently starting from cephamycin A and/or B by a "new route" process comprising the consecutive steps of reaction of cephamycin with 5-mercapto-1-methyl-1H-tetrazole; protection of the terminal amino group thereof by acylation; protection of the two carboxyl groups thereof by esterification; replacement of the acyl group initially having attached to the 7-amino group by a halogenoacetyl group; deprotection of the blocked 4-carboxyl group; and condensation of D-cysteine with the halogenoacetyl group attaching to the 7-amino group.

    摘要翻译： 7β-[（2D-2-氨基-2-羧基）乙硫基乙酰氨基]-7α-甲氧基-3 - [（1-甲基-1H-四唑-5-基）硫代甲基] -3- 头孢霉素-4-羧酸从头孢霉素A和/或B开始通过包含头孢霉素与5-巯基-1-甲基-1H-四唑的连续步骤的“新途径”方法经济有效地产生; 通过酰化保护其末端氨基; 通过酯化保护其两个羧基; 用卤代乙酰基取代最初连接在7-氨基上的酰基; 封闭的4-羧基脱保护; 和D-半胱氨酸与连接于7-氨基的卤代乙酰基缩合。

    "> Antibiotic 9-acyl-3
    10.
    发明授权
    Antibiotic 9-acyl-3"-thiomethoxymethyl-SF-837 composition and process for preparing the same 失效
    抗生素9-酰基-3 {41-甲氧基甲基-SF-837组合物及其制备方法

    公开(公告)号：US4029881A

    公开(公告)日：1977-06-14

    申请号：US345752

    申请日：1973-03-28

    申请人： Shigeharu Inouye ,  Shoji Omoto ,  Taro Niida ,  Bunzo Nomiya

    发明人： Shigeharu Inouye ,  Shoji Omoto ,  Taro Niida ,  Bunzo Nomiya

    IPC分类号： A01N43/22 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08 ,  A01N43/22

    摘要： A new derivative of the macrolide antibiotic SF-837 substance is manufactured by treating a 9,2'-diacyl- or 9-acyl-SF-837 composition with dimethylsulfoxide and acetic anhydride, and, subsequently, with an alcohol or water-containing solvent to yield the novel compound, 9-Acyl-3"-thiomethoxymethyl-SF-837 composition. In addition to high therapeutic effectiveness and low acute toxicity, this novel compound of the present invention has the great advantages that it does not have the bitter taste originally accompanying the parent compounds, and the further advantage that it is suitable for pediatric and veterinary use.

    摘要翻译： 通过用二甲基亚砜和乙酸酐处理9,2'-二酰基或9-酰基-SF-837组合物，然后用醇或含水溶剂来制备大环内酯类抗生素SF-837物质的新衍生物 得到新的化合物9-酰基-3“ - 硫代甲氧基甲基-SF-837组合物。 本发明的新型化合物除了具有高治疗效果和低急性毒性外，还具有不具有原始伴随母体化合物的苦味的优点，其优点在于适合于儿科和兽医用途。