公开(公告)号：US08603821B2

公开(公告)日：2013-12-10

申请号：US12529664

申请日：2008-03-05

Applicant: Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

Inventor： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

IPC: C12N5/00 ,  A61K35/14

CPC classification number: A61K35/16 ,  A61M1/0218 ,  A61M1/0281 ,  A61M1/029 ,  A61M2202/0423

Abstract: A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

Abstract translation: 提供一种制备血清和血清制备装置的方法，其可以产生大量的具有高培养效率的血清，而不管所用血液的新鲜度。 在至少含有血小板的血液制备血清的方法中，提供血小板的血小板膜被破坏的血小板加工步骤。 在血小板处理步骤之后，优选提供用于在血液中沉积热不稳定蛋白质的沉积步骤和用于去除在沉积步骤中沉积的不耐热蛋白质的去除步骤。

公开(公告)号：US08419705B2

公开(公告)日：2013-04-16

申请号：US12670971

申请日：2008-07-25

Applicant: Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

Inventor： Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

IPC: A61B19/00

CPC classification number: A61M1/3693 ,  A61M1/029

Abstract: It is intended to provide an apparatus for separating and storing blood components which facilitates the preparation of serum. An apparatus (1) for separating and storing blood components which comprises a blood pooling part (2) for pooling a fluid at least containing liquid components containing a blood-origin coagulation factors and platelets, a component storing part (3) for storing at least a part of the components of the fluid pooled in the blood pooling part (2), and a connector part (4) aseptically connecting the blood pooling part (2) to the component storing part (3), wherein the blood pooling part (2) comprises a blood pooling container (21) in the form of a flexible tube, a fluid inlet channel (27) for introducing the fluid into the blood pooling container (21) and a component outlet channel (28) for leading out at least a part of the components of the fluid; the component storing part (3) has a component inlet channel (37) for introducing at least a part of the components of the fluid having been led out from the blood pooling container (21); and the connector part (4) connects the component outlet channel (28) to the component inlet channel (37).

Abstract translation: 旨在提供一种用于分离和储存促进血清制备的血液成分的装置。 一种用于分离和储存血液成分的装置（1），其包括用于汇集至少含有血液凝固因子和血小板的液体成分的流体的血液收集部分（2），用于至少存储血液凝固因子和血小板的成分存储部分 汇集在血液收集部分（2）中的流体的一部分部分，以及将血液收集部分（2）无菌地连接到部件存储部分（3）的连接器部分（4），其中血液收集部分 ）包括柔性管形式的血液储存容器（21），用于将流体引入血液储存容器（21）的流体入口通道（27）和用于引导至少一个 流体的一部分组分; 所述部件收纳部（3）具有用于导入从所述血液容纳容器（21）引出的所述流体的成分的至少一部分的成分入口通路（37）。 并且连接器部分（4）将部件出口通道（28）连接到部件入口通道（37）。

公开(公告)号：USD624173S1

公开(公告)日：2010-09-21

申请号：US29341995

申请日：2009-08-17

Applicant: Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

Designer： Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

公开(公告)号：US20090075355A1

公开(公告)日：2009-03-19

申请号：US11719392

申请日：2005-11-02

Applicant: Koji Suzuki ,  Seishin Tanaka

Inventor： Koji Suzuki ,  Seishin Tanaka

IPC: C12N9/00

CPC classification number: C12N5/0018 ,  A61K35/16 ,  C12N2501/135 ,  C12N2501/15

Abstract: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

Abstract translation: 旨在提供含有能够有效促进干细胞生长的大量生长因子的血清。 相对于血小板的全部量，血液收集后20分钟内剩余的血小板残留率的细胞培养用人血清为0〜20％，细胞生长因子的释放率为20〜100％ 。

公开(公告)号：US06293921B1

公开(公告)日：2001-09-25

申请号：US09254319

申请日：1999-08-25

Applicant: Kazuhiro Shinmoto ,  Seishin Tanaka ,  Junya Fujii

Inventor： Kazuhiro Shinmoto ,  Seishin Tanaka ,  Junya Fujii

IPC: A61M100

CPC classification number: A61M1/28 ,  A61M1/288 ,  A61M39/10

Abstract: An automatic exchanger apparatus for peritoneal dialysis fluids is provided having a dialysis fluid bag and a drained fluid bag and arranged for connecting and disconnecting between the end of a peritoneal dialysis circuit equipped with a branching point and the end of a tube extending from a patient to drain the waste dialysis fluid from the cavity of the patient and fill the peritoneal cavity of the patient with a fresh peritoneal dialysis fluid for exchange, and in particular comprises: means A, B, and C for carrying out respectively a step (A) of connecting the end of the patient side tube to the end of the peritoneal dialysis circuit, a step (B) of delivering and draining the waste fluid, and a step (C) of, disconnecting the two ends and connecting the end of the patient side tube to its shut-off member, arranged for carrying out their respective steps (A) and (C) automatically; and a controlling means for controlling the respectively means to execute their respectively steps in a sequence. The apparatus is simple in the construction while carrying out, with much ease, the connection and disconnection of the tubes and the exchange of the fluids including a waste and a fresh supply one, hence avoiding operational errors of the operator and minimizing the possibility of infection and contamination.

Abstract translation: 提供了一种腹膜透析液自动交换装置，其具有透析液袋和排液流体袋，并布置成用于连接和断开配备有分支点的腹膜透析回路的末端和从患者延伸到管的末端 从患者的空腔排出废液透析液，并用新鲜的腹膜透析液填充患者的腹膜以进行交换，特别地包括：用于分别执行步骤（A）的方法A，B和C， 将患者侧管的端部连接到腹膜透析回路的末端，输送和排出废液的步骤（B）;以及步骤（C），断开两端并连接患者侧的端部 管连接到其关闭构件，被布置成自动执行它们各自的步骤（A）和（C）; 以及控制装置，用于按顺序控制分别执行其各自步骤的装置。 该设备结构简单，同时轻松执行管的连接和断开以及包括废物和新鲜供应的流体的交换，从而避免操作者的操作错误并最小化感染的可能性 和污染。

公开(公告)号：US08679838B2

公开(公告)日：2014-03-25

申请号：US12705298

申请日：2010-02-12

Applicant: Koji Suzuki ,  Seishin Tanaka

Inventor： Koji Suzuki ,  Seishin Tanaka

IPC: C12N5/07 ,  C12N5/10 ,  A01N1/02 ,  C12N5/00 ,  C12N5/02 ,  C12N5/071 ,  C12M1/00 ,  C12M1/38 ,  C12M3/00 ,  C12M1/34

CPC classification number: C12N5/0018 ,  A61K35/16 ,  C12N2501/135 ,  C12N2501/15

Abstract: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount of the platelets is 0% to 20%, and a release ratio of cell growth factors is 20% to 100%.

Abstract translation: 旨在提供含有能够有效促进干细胞生长的大量生长因子的血清。 相对于血小板的全部量，血液收集后20分钟内剩余的血小板残留率的细胞培养用人血清为0〜20％，细胞生长因子的释放率为20〜100％ 。

公开(公告)号：US20110301564A1

公开(公告)日：2011-12-08

申请号：US13147300

申请日：2010-01-22

Applicant: Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

Inventor： Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

IPC: A61J1/14

CPC classification number: A61F5/44 ,  A61M1/0209 ,  A61M1/0231 ,  A61M1/025

Abstract: A liquid component collecting device capable of more easily collecting a liquid component. A liquid component collecting device(100) is provided with: a flexible cylindrical liquid component storage container (21) having an opening at one end thereof; a cylindrical first housing container (22) for housing the liquid component storage container (21) and having an opening at one end thereof; and a first cap (23) connected to the opening in the liquid component storage container (21) and fitted to the opening in the first housing container (22). A pressure regulating space (26) independent of the internal space of the liquid component storage container (21) is formed between the outer side of the liquid component storage container (21) and the inner side of the first housing container (22). The first cap (23) is provided with a liquid component inlet channel (27) for introducing blood into the liquid component storage container (21), a first communication channel (28) communicating with the internal space of the liquid component storage container (21), and a second communication channel (29) communicating with the pressure regulating space (26).

Abstract translation: 一种能够更容易地收集液体成分的液体成分收集装置。 液体成分收集装置（100）具有：一端具有开口的柔性圆柱形液体容纳容器（21）; 用于容纳所述液体部件收容容器（21）并且在其一端具有开口的圆柱形的第一容纳容器（22） 以及与液体部件收纳容器（21）的开口部连接并与第一容纳容器（22）的开口嵌合的第一盖（23）。 在液体容纳容器（21）的外侧和第一容纳容器（22）的内侧之间形成有独立于液体容纳容器（21）的内部空间的压力调节空间（26）。 第一盖（23）设置有用于将血液引入液体容纳容器（21）中的液体成分入口通道（27），与液体容纳容器（21）的内部空间连通的第一连通通道 ）和与压力调节空间（26）连通的第二连通通道（29）。

公开(公告)号：USD626645S1

公开(公告)日：2010-11-02

申请号：US29341992

申请日：2009-08-17

Applicant: Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

Designer： Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

公开(公告)号：USD624175S1

公开(公告)日：2010-09-21

申请号：US29341999

申请日：2009-08-17

Applicant: Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

Designer： Masayoshi Omori ,  Seishin Tanaka ,  Yasunori Okamoto

公开(公告)号：US20100120150A1

公开(公告)日：2010-05-13

申请号：US12529664

申请日：2008-03-05

Applicant: Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

Inventor： Koji Suzuki ,  Seishin Tanaka ,  Satoshi Hirai ,  Mari Takabatake

IPC: C12N5/00

CPC classification number: A61K35/16 ,  A61M1/0218 ,  A61M1/0281 ,  A61M1/029 ,  A61M2202/0423

Abstract: A method for preparing serum and a serum preparation apparatus is provided that can give a large amount of serum with high culture efficiency regardless of freshness of blood used. In a method for preparing serum from blood containing at least platelets, a platelet processing step is provided in which platelet membrane in the blood is destroyed. After the platelet processing step, a deposition step for depositing thermolabile protein in blood and a removal step for removing the thermolabile protein, which has been deposited in the deposition step, are preferably provided.

Abstract translation: 提供一种制备血清和血清制备装置的方法，其可以产生大量的具有高培养效率的血清，而不管所用血液的新鲜度。 在至少含有血小板的血液制备血清的方法中，提供血小板的血小板膜被破坏的血小板加工步骤。 在血小板处理步骤之后，优选提供用于在血液中沉积热不稳定蛋白质的沉积步骤和用于去除在沉积步骤中沉积的不耐热蛋白质的去除步骤。