公开(公告)号：US20240045482A1

公开(公告)日：2024-02-08

申请号：US17883213

申请日：2022-08-08

申请人： Ryan White

发明人： Ryan White

IPC分类号： G06F1/20 ,  F28D15/02

CPC分类号： G06F1/203 ,  F28D15/0266 ,  G06F2200/201

摘要： A laptop cooling pad with an external AC Unit having one or more heat-dissipating fans adjustable in position is disclosed with a cooler circulating cool air to the pad in question. The laptop cooling pad is provided with a ventilation portion so that a heat-dissipating fan can be mounted on the ventilation portion through a fan support. The ventilation portion has a groove for receiving AC cooled liquid through the radiator so cool air can circular using fan support to move the heat-dissipating fan inside the laptop cooling pad and make the heat-dissipating fan close to a heat source, thereby ensuring the heat-dissipating effect of the laptop cooling pad. With an added function of a cooler air to be flown through specific pipes and ventilation systems. The utility model discloses a laptop cooler which comprises an upper cover plate, a bottom plate, a support, a fan, a refrigerating machine, a condenser pipe, aluminum sheets, an exhaust fan and a slide track, wherein the refrigerating machine is arranged on and attached to the bottom plate and is connected with the condenser pipe; the condenser pipe is located below the fan; the aluminum sheets parallel to a cross section of the condenser pipe are arranged outside the condenser pipe; the slide track is arranged on the upper cover plate matched with the bottom plate; the exhaust fan is arranged on the slide track; and the support is arranged below the bottom plate. The laptop cooler can blow out cold air, air movement in a laptop is accelerated, the cooling efficiency of the laptop is accelerated via the external AC cooling unit adjacent to it, and the service life of the laptop is prolonged.

公开(公告)号：US08882069B2

公开(公告)日：2014-11-11

申请号：US13014691

申请日：2011-01-26

申请人： Robert Mahaffey ,  Will Ali ,  John Tan ,  John Hung ,  Ryan White ,  Wilson Tse

发明人： Robert Mahaffey ,  Will Ali ,  John Tan ,  John Hung ,  Ryan White ,  Wilson Tse

IPC分类号： A47F5/00 ,  A47K1/08 ,  A47B91/00 ,  A47G29/00 ,  B65D19/00 ,  E05B69/00 ,  E05B73/00 ,  E05B63/00

CPC分类号： E05B73/0082 ,  E05B63/0056 ,  E05B73/0005 ,  F16M11/2007 ,  F16M11/2092 ,  F16M11/24 ,  H05K5/0204 ,  Y10T29/49826 ,  Y10T70/411 ,  Y10T70/5009 ,  Y10T70/5566

摘要： An apparatus for securing an electronic device includes a main body with two ends. An arm is provided at one end of the main body, and has a hook attached thereto, shaped for the electronic device to be placed between the hook and the arm. An additional arm is slidably attached to the other end of the main body, and is capable of being slid by a user to several lateral positions relative to the main body. An additional hook is provided on the slidable arm, and is shaped for the electronic device to be placed between the hook and the arm. A locking system is provided to lock and unlock the slidable arm to at least one of the lateral positions. A base section is capable of being secured at or near a location. The main body is adjustably attached to the base section.

摘要翻译： 用于固定电子装置的装置包括具有两端的主体。 臂设置在主体的一端，并且具有附接到其上的钩状物，其形状适于放置在钩和臂之间的电子装置。 附加的臂可滑动地附接到主体的另一端，并且能够被用户滑动到相对于主体的几个横向位置。 在可滑动臂上设置有一个附加的钩子，并且被成形为用于将电子设备放置在钩和臂之间。 提供锁定系统以将可滑动臂锁定和解锁到至少一个横向位置。 基座部分能够固定在某个位置处或附近。 主体可调节地附接到基部。

公开(公告)号：US08497264B2

公开(公告)日：2013-07-30

申请号：US13047693

申请日：2011-03-14

申请人： Jian J. Chen ,  Wenge Zhong ,  Bryant Yang ,  Ryan White ,  Matthew Weiss ,  Timothy Powers ,  Yuan Cheng

发明人： Jian J. Chen ,  Wenge Zhong ,  Bryant Yang ,  Ryan White ,  Matthew Weiss ,  Timothy Powers ,  Yuan Cheng

IPC分类号： C07D513/10 ,  C07D498/20 ,  A61K31/547 ,  A61K31/5386

CPC分类号： C07D513/10 ,  C07D498/10 ,  C07D498/20 ,  C07D513/20

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

公开(公告)号：US20120125057A1

公开(公告)日：2012-05-24

申请号：US13306534

申请日：2011-11-29

申请人： Robert Mahaffey ,  John Hung ,  John Tan ,  Will Ali ,  Ryan White ,  Michael (Xiao Lei) Liang

发明人： Robert Mahaffey ,  John Hung ,  John Tan ,  Will Ali ,  Ryan White ,  Michael (Xiao Lei) Liang

IPC分类号： E05B73/00 ,  B23P11/00 ,  F16B17/00 ,  E05B19/00

CPC分类号： E05B73/00 ,  E05B67/36 ,  E05B73/0005 ,  E05B73/0082 ,  Y10T29/49002 ,  Y10T29/49826 ,  Y10T70/40 ,  Y10T70/443 ,  Y10T70/483 ,  Y10T70/5009 ,  Y10T70/5867 ,  Y10T70/7706 ,  Y10T403/70 ,  Y10T403/7037

摘要： A security apparatus is disclosed. The security apparatus comprises an attachment device comprising a base, and a locking head configured to secure to the base. The locking head can have a securing element and a locking component, associated with a housing. The locking head may be in a secured configuration upon a single motion or movement of the locking head.

摘要翻译： 公开了一种安全装置。 安全装置包括附接装置，其包括基座和构造成固定到基座的锁定头。 锁定头可以具有与壳体相关联的固定元件和锁定部件。 在锁定头的单一运动或移动时，锁定头可以处于固定构造。

公开(公告)号：US20120122847A1

公开(公告)日：2012-05-17

申请号：US13157195

申请日：2011-06-09

申请人： Victor Cee ,  Holly Deak ,  Bingfan Du ,  Stephanie Geuns-Meyer ,  Zihao Hua ,  Matthew Martin ,  Issac Marx ,  Hanh Nho Nguyen ,  Philip Olivieri ,  Kathleen Panter ,  Karina Romero ,  Laurie Schenkel ,  Ryan White

发明人： Victor Cee ,  Holly Deak ,  Bingfan Du ,  Stephanie Geuns-Meyer ,  Zihao Hua ,  Matthew Martin ,  Issac Marx ,  Hanh Nho Nguyen ,  Philip Olivieri ,  Kathleen Panter ,  Karina Romero ,  Laurie Schenkel ,  Ryan White

IPC分类号： A61K31/502 ,  A61P35/00 ,  C07D413/14 ,  A61K31/5377 ,  C07D471/04 ,  A61K31/55

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04

摘要： The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

摘要翻译： 本发明涉及具有通式I的化合物，其中A1-8，D'，L1，L2，R1，R6-8和n定义在本文中，以及合成中间体，其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如，化合物能够调节Aurora激酶，从而影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物，包括该化合物，以及治疗与Aurora激酶活性有关的疾病状态的方法。

公开(公告)号：US20110251190A1

公开(公告)日：2011-10-13

申请号：US13047734

申请日：2011-03-14

申请人： Yuan CHENG ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

发明人： Yuan CHENG ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

IPC分类号： A61K31/538 ,  A61K31/436 ,  C07D413/14 ,  C07D417/14 ,  A61K31/444 ,  A61P25/00 ,  C07D513/10 ,  A61K31/4545 ,  C07D498/10 ,  A61K31/497 ,  A61P25/28 ,  A61P25/16 ,  C07D513/20 ,  A61K31/506

CPC分类号： C07D491/10 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D221/20 ,  C07D235/02 ,  C07D263/08 ,  C07D295/135 ,  C07D498/10 ,  C07D498/20 ,  C07D513/10 ,  C09B11/28

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和其它相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I中的A1，A2，A3，A4，A5，A6，R2，R7，X和Y如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

公开(公告)号：US20110251186A1

公开(公告)日：2011-10-13

申请号：US13047693

申请日：2011-03-14

申请人： Jian J. CHEN ,  Wenge ZHONG ,  Bryant YANG ,  Wenyuan QIAN ,  Patricia LOPEZ ,  Ryan WHITE ,  Matthew WEISS ,  Ted JUDD ,  Timothy POWERS ,  Yuan CHENG ,  Thomas DINEEN ,  Oleg EPSTEIN ,  Jonathan LOW ,  Isaac MARX ,  Ana Elena MINATTI ,  Michele POTASHMAN ,  Nick A. PARAS

发明人： Jian J. CHEN ,  Wenge ZHONG ,  Bryant YANG ,  Wenyuan QIAN ,  Patricia LOPEZ ,  Ryan WHITE ,  Matthew WEISS ,  Ted JUDD ,  Timothy POWERS ,  Yuan CHENG ,  Thomas DINEEN ,  Oleg EPSTEIN ,  Jonathan LOW ,  Isaac MARX ,  Ana Elena MINATTI ,  Michele POTASHMAN ,  Nick A. PARAS

IPC分类号： A61K31/547 ,  A61P25/28 ,  C07D513/10 ,  C07D498/20 ,  A61K31/5386

CPC分类号： C07D513/10 ,  C07D498/10 ,  C07D498/20 ,  C07D513/20

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I中的A1，A2，A3，A4，A5，A6，R2，R7，X，Y和Z如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

公开(公告)号：US07997106B2

公开(公告)日：2011-08-16

申请号：US12969401

申请日：2010-12-15

申请人： Robert Mahaffey ,  John Hung ,  John Tan ,  Will Ali ,  Ryan White ,  Michael Xiao Lei Liang

发明人： Robert Mahaffey ,  John Hung ,  John Tan ,  Will Ali ,  Ryan White ,  Michael Xiao Lei Liang

IPC分类号： E05B73/00

CPC分类号： E05B73/00 ,  E05B67/36 ,  E05B73/0005 ,  E05B73/0082 ,  Y10T29/49002 ,  Y10T29/49826 ,  Y10T70/40 ,  Y10T70/443 ,  Y10T70/483 ,  Y10T70/5009 ,  Y10T70/5867 ,  Y10T70/7706 ,  Y10T403/70 ,  Y10T403/7037

摘要： A security apparatus is disclosed. The security apparatus comprises an attachment device comprising a base, and a locking head configured to secure to the base. The attachment device can be small and strong. The locking head can have a securing element and a locking component, associated with a housing. The locking head may be in a secured configuration upon a single motion or movement of the locking head.

摘要翻译： 公开了一种安全装置。 安全装置包括附接装置，其包括基座和构造成固定到基座的锁定头。 附件装置可小而强。 锁定头可以具有与壳体相关联的固定元件和锁定部件。 在锁定头的单一运动或移动时，锁定头可以处于固定构造。

公开(公告)号：US07981891B2

公开(公告)日：2011-07-19

申请号：US12828067

申请日：2010-06-30

申请人： Holly Deak ,  Stephanie Geuns-Meyer ,  Brian L. Hodous ,  Zihao Hua ,  Mathew Martin ,  Hanh Nho Nguyen ,  Philip Olivieri ,  Kate Panter ,  Karina Romero ,  Laurie Schenkel ,  Ryan White

发明人： Holly Deak ,  Stephanie Geuns-Meyer ,  Brian L. Hodous ,  Zihao Hua ,  Mathew Martin ,  Hanh Nho Nguyen ,  Philip Olivieri ,  Kate Panter ,  Karina Romero ,  Laurie Schenkel ,  Ryan White

IPC分类号： A61K31/502

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04

摘要： The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

摘要翻译： 本发明涉及具有通式I的化合物，其中A1-8，D'，L1，L2，R1，R6-8和n定义在本文中，以及合成中间体，其能够调节各种蛋白激酶受体酶和 从而影响与这种激酶的活性相关的各种疾病状态和状况。 例如，化合物能够调节Aurora激酶，从而影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物，包括该化合物，以及治疗与Aurora激酶活性有关的疾病状态的方法。

公开(公告)号：US20110013361A1

公开(公告)日：2011-01-20

申请号：US12446556

申请日：2007-10-22

申请人： Ryan White ,  John Hung ,  Lambert Kuo

发明人： Ryan White ,  John Hung ,  Lambert Kuo

IPC分类号： E05B73/00 ,  E05B17/00 ,  G06F1/16

CPC分类号： G06F1/1656 ,  E05B73/00 ,  E05B73/0005 ,  E05B73/0082 ,  G06F1/16 ,  Y10T70/402 ,  Y10T70/413 ,  Y10T70/50 ,  Y10T70/5009 ,  Y10T70/8973

摘要： A security apparatus is disclosed. The security apparatus is used with a lock interface member attached to a housing of a portable electronic device. The security apparatus may include an engagement element as well as a stabilizing element. The engagement element and the stabilizing element may secure the security apparatus to the lock interface member, and therefore to the housing of the portable electronic device.

摘要翻译： 公开了一种安全装置。 安全装置与附接到便携式电子装置的壳体的锁定接口构件一起使用。 安全装置可以包括接合元件以及稳定元件。 接合元件和稳定元件可以将安全装置固定到锁定接口构件，并因此固定到便携式电子设备的壳体。