摘要:
The present invention provides compounds of Formula I or II, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
摘要:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.
摘要:
A panel siding assembly adapted to be mounted to an outside surface of a wall in a manner to provide an air space between the siding assembly and the wall so that moist air in the air space is able to escape from the air space. The assembly comprises a plurality of laterally aligned panels having upper and lower panel edge portions and outside and inside surfaces. The panels are located at vertically spaced locations so that each pair of upper and lower adjacent panels are positioned so that an upper front surface portion of the lower panel of the pair is adjacent to a lower rear surface portion of the upper panel of the pair at a laterally extending juncture location. There is a plurality of spacing and locating devices which are positioned at spaced locations along the juncture location.
摘要:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
摘要:
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要:
A method for playing a cooperative card wagering game for a plurality of players and a dealer using a customer cooperative wagering table and a deck of cards with each card having a numerical value, the cooperative wagering table having a dealer table edge, a community table edge, and a community line positioned therebetween, each player has an individual hand, and contributes a card to form a community hand by placing the card upon the community line, the players cooperate to maximize the value of the community hand, while also maximizing their respective individual hands, whereby the players cannot obtain a player win result if the community hand is less than the dealer's hand in value.
摘要:
A method for playing a dual-hand card wagering game with a player and a dealer using a wagering table and a deck of cards with each card having a numerical value, the player is dealt cards to form a primary hand, and transfers a card from the primary hand to form a secondary hand, while the dealer retains cards to form a dealer hand. The total numerical values of the primary hand and the secondary hand are compared to the dealer hand to determine a primary result and a secondary result corresponding to a primary or secondary loss, tie, or win. The primary and secondary results are considered in combination to determine a game result corresponding to a player win, player push, or player loss. The dual-hand card wagering game may also be played electronically using a dual-hand card game system.
摘要:
The present invention provides compounds of Formula I or II, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
摘要:
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.