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公开(公告)号：US07067273B2
公开(公告)日：2006-06-27
申请号：US10741205
申请日：2003-12-19
申请人： Rumin Zhang , Jun Zou , Feng X. Zhu , James P. Durkin , William T. Windsor , Shelby P. Umland
发明人： Rumin Zhang , Jun Zou , Feng X. Zhu , James P. Durkin , William T. Windsor , Shelby P. Umland
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C12N9/6489 , C12Q1/37 , G01N2500/00
摘要： The present invention discloses peptide substrates of a proteolytic ADAM33 polypeptide. The present invention also discloses methods of identifying additional substrates of a proteolytic ADAM33 polypeptide. Furthermore, the present invention discloses methods of identifying compounds that inhibit the proteolytic activity of a proteolytic ADAM33 polypeptide.
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公开(公告)号：US07705127B1
公开(公告)日：2010-04-27
申请号：US12249314
申请日：2008-10-10
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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3.发明授权Soluble, stable form of HDM2, crystalline forms thereof and methods of use thereof 失效可溶性，稳定形式的HDM2，其结晶形式及其使用方法公开(公告)号：US07632920B2
公开(公告)日：2009-12-15
申请号：US10822254
申请日：2004-04-09
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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4.发明申请公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法 蛋白质或P53使用这些化合物或药物组合物。
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公开(公告)号：US20100119483A1
公开(公告)日：2010-05-13
申请号：US12508095
申请日：2009-07-23
申请人： Rong Liu , Rumin Zhang , Rong Kong
发明人： Rong Liu , Rumin Zhang , Rong Kong
IPC分类号： A61K38/21 , C07K2/00 , A61K38/02 , A61K39/395 , C07H21/00 , C12N15/74 , C12N5/071 , C12P21/02 , A61P31/12 , A61P31/14 , A61P31/18 , A61P37/04
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505
摘要： The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., HCV) infections.
摘要翻译： 本发明尤其提供了用于治疗和预防黄病毒科病毒（例如HCV）感染的肽组合物和方法。
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公开(公告)号：US07592315B2
公开(公告)日：2009-09-22
申请号：US11264509
申请日：2005-11-01
申请人： Rong Liu , Rumin Zhang , Rong Kong
发明人： Rong Liu , Rumin Zhang , Rong Kong
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505
摘要： The present invention provides, inter alia, peptide compositions and methods for treating and preventing Flaviviridae virus (e.g., hepatitis C virus) infections.
摘要翻译： 本发明尤其提供用于治疗和预防黄病毒科病毒（例如丙型肝炎病毒）感染的肽组合物和方法。
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公开(公告)号：US07446195B2
公开(公告)日：2008-11-04
申请号：US11505263
申请日：2006-08-16
申请人： Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人： Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号： C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12
CPC分类号： C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译： 描述了细胞周期蛋白依赖性激酶2的抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
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公开(公告)号：US20070043045A1
公开(公告)日：2007-02-22
申请号：US11505263
申请日：2006-08-16
申请人： Yongqi Deng , Lianyun Zhao , Gerald Shipps , Patrick Curran , M. Siddiqui , Rumin Zhang , Charles McNemar , Todd Mayhood , William Windsor , Emma Lees , David Parry
发明人： Yongqi Deng , Lianyun Zhao , Gerald Shipps , Patrick Curran , M. Siddiqui , Rumin Zhang , Charles McNemar , Todd Mayhood , William Windsor , Emma Lees , David Parry
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4439 , A61K31/4709 , A61K31/428 , A61K31/42 , A61K31/4196 , A61K31/4178 , A61K31/4025 , A61K31/416 , C07D413/02 , C07D405/02 , C07D409/02 , C07D417/02
CPC分类号： C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译： 描述了细胞周期蛋白依赖性激酶2的抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
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9.发明授权Polynucleotides encoding soluble, stable forms of human double minute 2 polypeptides 失效编码可溶性，稳定形式的人类双分子2多肽的多核苷酸公开(公告)号：US08034907B2
公开(公告)日：2011-10-11
申请号：US12621241
申请日：2009-11-18
申请人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
发明人： Shahriar Shane Taremi , Gaolian Xie , Thomas Hesson , Jose S. Duca , Corey Strickland , William T. Windsor , Vincent S. Madison , Rumin Zhang , Paul Reichert , Yaolin Wang
CPC分类号： C07H21/04 , C07D209/20 , C07K14/47 , C07K2299/00
摘要： The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.
摘要翻译： 本发明公开了可溶性的修饰的Hdm2蛋白。 此外，本发明公开了编码本发明的修饰的Hdm2蛋白质的核酸。 本发明还提供了适用于X射线结晶分析的修饰的Hdm2蛋白晶体。 本发明还公开了使用修饰的Hdm2蛋白及其晶体鉴定，选择和/或设计可用作抗癌剂的化合物的方法。 本发明还公开了与蛋白质 - 配体复合物中的修饰的Hdm2蛋白结合的化合物。
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公开(公告)号：US07888474B2
公开(公告)日：2011-02-15
申请号：US12723184
申请日：2010-03-12
申请人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
发明人： Thomas E. Hesson , Hung V. Le , Yao Ma , Vincent S. Madison , Anthony F. Mannarino , Paul Reichert , Gerald W. Shipps, Jr. , Corey O. Strickland , Shahriar Shane Taremi , Yaolin Wang , Rumin Zhang , Jose Duca
IPC分类号： C07K14/00
CPC分类号： C07K14/82 , C07K2299/00
摘要： The present invention relates to HDM2 polypeptides and mutants thereof which are complexed with various compounds, e.g., HDM2 inhibitors.
摘要翻译： 本发明涉及与各种化合物例如HDM2抑制剂复合的HDM2多肽及其突变体。
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