摘要:
The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要:
Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要:
The present invention provides compounds of formula I wherein X, Y, R1-R7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA polymerase and treating hepatitis C and related disorders using these compounds and compositions are also provided.
摘要:
In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要:
A powertrain control method and strategy for a hybrid electric vehicle is disclosed including establishing electric motor-generator regenerative braking on a first driving axle and engine compression braking for a second driving axle when the vehicle is in a deceleration mode and friction braking the first driving axle when regenerative braking, the friction braking complementing regenerative braking to satisfy a given total braking request.
摘要:
A high tensile strength, highly conductive flexible composite sheet consisting of fibrillated PTFE polymers, performance enhancing dopants, and carbon particles useful in electrochemical devices such as flow through capacitors, capacitive deionization, electronic water purification, fuel cells, capacitors, super-capacitors and a method of preparation. The method consists of mixing the materials and calendering to the desired thickness and strength all at room temperature and leaving the material in a wet state without further drying.
摘要:
A method of obtaining an enantioenriched organic compound comprising the steps of: 1) generating from a starting racemic, non-enantiopure or achiral compound a first mixture comprising at least one fluorous-tagged compound and at least one other non-fluorous tagged compound, at least one of these two compounds being enantioenriched relative to the starting compound; 2) contacting a first non-fluorous phase including the first mixture with a fluorous phase at a first phase interface, the fluorous-tagged compound distributing between the first non-fluorous phase and the fluorous phase; and 3) contacting the fluorous phase with a second non-fluorous phase at a second phase interface. The method further includes the step of having a third compound in the second non-fluorous phase that reacts with the fluorous-tagged compound to produce a second compound and the step of generating the first mixture by chemical or enzymatic kinetic resolution of a racemic or non-enantiopure compound.
摘要:
A portable toilet is provided comprising a bowl provided with an outlet and at least one spout. A flush tank is adapted to store a fluid, wherein the flush tank is adapted to be pressurized. A manually-actuated pump is in sealed communication with the flush tank, wherein the pump is adapted to cause the flush tank to become pressurized. A pressure relief valve adapted to release pressure from the flush tank. A manually-actuated flush valve is in sealed communication with the flush tank and is normally biased to a closed position. The flush valve includes a fluid outlet connected to the at least one spout and a fluid inlet. A flush valve actuator is disposed outside of the flush tank and is adapted to actuate the flush valve, wherein actuation of the flush valve actuator causes the flush valve to open to permit pressurized fluid contained within the flush tank to be delivered through the at least one spout.
摘要:
Systems and methods are provided for event detection. One embodiment includes an interface that acquires logs, and a controller that is able to identify events recited in the logs, to include the events within a list sorted based on at least one of start times or end times indicated by the timing data, and to determine a longest duration of the events. The controller receives a requested time, calculates a prior time separated by the longest duration from the requested time, and processes the list by: identifying a first index of the list for a first event in time having a start time on or after the prior time, and identifying a last index of the list for a last event in time having a start time on or before the requested time. The controller generates a set of events bounded by the first index and the last index.
摘要:
A high tensile strength, highly conductive flexible composite sheet consisting of fibrillated PTFE polymers, performance enhancing dopants, and carbon particles useful in electrochemical devices such as flow through capacitors, capacitive deionization, electronic water purification, fuel cells, capacitors, super-capacitors and a method of preparation. The method consists of mixing the materials and calendering to the desired thickness and strength all at room temperature and leaving the material in a wet state without further drying.