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    N-ACYLDIPEPTIDE DERIVATIVES AND THEIR USES
    4.
    发明申请
    N-ACYLDIPEPTIDE DERIVATIVES AND THEIR USES 审中-公开
    N-亚胺代谢衍生物及其用途

    公开(公告)号：US20160271203A1

    公开(公告)日：2016-09-22

    申请号：US15171601

    申请日：2016-06-02

    申请人： Ruey J. YU ,  Eugene J. VAN SCOTT

    发明人： Ruey J. YU ,  Eugene J. VAN SCOTT

    IPC分类号： A61K38/05 ,  A61K9/00

    摘要： N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for treating disorders and condition associated with the nervous system or musculoskeletal system, such as pain, weakness, numbness, arthritis, joint inflammation, weakness of muscles or joints, and myopia.

    摘要翻译： 描述N-酰基二肽衍生物。 包含N-酰基二肽衍生物的组合物对于治疗与神经系统或肌肉骨骼系统相关的疾病和病症是治疗有效的，例如疼痛，虚弱，麻木，关节炎，关节炎症，肌肉或关节的弱点和近视。

    SCIENTIFIC GOLF AND EQUIPMENT
    5.
    发明申请
    SCIENTIFIC GOLF AND EQUIPMENT 审中-公开
    科学高尔夫和设备

    公开(公告)号：US20140057735A1

    公开(公告)日：2014-02-27

    申请号：US13972424

    申请日：2013-08-21

    申请人： Ruey J. Yu

    发明人： Ruey J. Yu

    IPC分类号： A63B53/02 ,  A63B53/00

    CPC分类号： A63B60/00 ,  A63B53/007 ,  A63B53/02 ,  A63B53/0466 ,  A63B53/0487 ,  A63B2053/0408

    摘要： A scientific method of golf employs a pendulous or near pendulous swing to hit a golf ball so that the ball flies airborne and straight, including a tee shot with a driver. A new golf club with the shaft attached to the heel of the club head as in conventional golf clubs, but with the shaft angle increased to about 65-90° is disclosed. Also disclosed are golf clubs and putters having a shaft attached at or near the center of the club or putter head.

    摘要翻译： 一种科学的高尔夫球方法采用了一种下垂或近摆摆动打高尔夫球，使球飞行空中直飞，包括用驾驶员射击的发球台。 公开了一种新的高尔夫球杆，其具有附接到球杆头的跟部的轴，如在常规高尔夫球杆中，但是轴角度增加到约65-90°。 还公开了具有连接在球杆或推杆头的中心处或附近的轴的高尔夫球杆和推杆。

    N-(Phosphonoalkyl)-Amino Acids, Derivatives Thereof and Compositions and Methods of Use
    8.
    发明申请
    N-(Phosphonoalkyl)-Amino Acids, Derivatives Thereof and Compositions and Methods of Use 有权
    N-（膦酰基烷基） - 氨基酸，其衍生物及其组合物和使用方法

    公开(公告)号：US20090208499A1

    公开(公告)日：2009-08-20

    申请号：US12428906

    申请日：2009-04-23

    申请人： Ruey J. Yu ,  Eugene J. Van Scott

    发明人： Ruey J. Yu ,  Eugene J. Van Scott

    IPC分类号： A61K31/662 ,  C07F9/44 ,  C07F9/6506 ,  C07F9/572 ,  A61K31/675 ,  A61K38/06 ,  A61K39/395 ,  A61P25/00 ,  A61P9/00

    CPC分类号： C07F9/3808 ,  A61K38/05 ,  C07F9/572 ,  C07F9/5728 ,  C07F9/58 ,  C07F9/6506 ,  C07F9/653

    摘要： The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, other than N-(phosphonomethyl)-glycine or N,N-bis(phosphonomethyl)-glycine. Also included is a composition including an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof in a form as a free acid, salt, partial salt, lactone, amide or ester, or in stereoisomeric or non-stereoisomeric form, and a cosmetically or pharmaceutically acceptable vehicle for topical or systemic administration to a mammalian subject, as well as a method of administering an effective amount of such a composition for alleviating or improving a condition, disorder, symptom or syndrome associated with at least one of a nervous, vascular, musculoskeletal or cutaneous system.

    摘要翻译： 本发明涉及N-（膦酰基烷基） - 氨基酸，相关化合物或其衍生物，N-（膦酰基烷基） - 氨基酸，作为游离酸形式的相关化合物或其衍生物，盐，部分 盐，内酯，酰胺或酯，或以N-（膦酰基甲基） - 甘氨酸或N，N-双（膦酰基甲基） - 甘氨酸以外的立体异构体或非立体异构体形式。 还包括作为游离酸，盐，部分盐，内酯，酰胺或酯形式的N-（膦酰基烷基） - 氨基酸，相关化合物或其衍生物或立体异构体或非立体异构形式的组合物 以及用于局部或全身给予哺乳动物受试者的化妆品或药学上可接受的载体，以及施用有效量的这种组合物以减轻或改善与以下中的至少一种相关的病症，障碍，症状或综合征的方法： 神经，血管，肌肉骨骼或皮肤系统。

    Compositions comprising phenyl-glycine derivatives
    9.
    发明授权
    Compositions comprising phenyl-glycine derivatives 有权
    包含苯基 - 甘氨酸衍生物的组合物

    公开(公告)号：US06824786B2

    公开(公告)日：2004-11-30

    申请号：US10294741

    申请日：2002-11-15

    申请人： Ruey J. Yu ,  Eugene J. Van Scott

    发明人： Ruey J. Yu ,  Eugene J. Van Scott

    IPC分类号： A61K700

    CPC分类号： A61Q3/00 ,  A61K8/44 ,  A61K31/19 ,  A61K31/198 ,  A61K31/205 ,  A61K31/223 ,  A61K45/06 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： The invention relates to compositions and methods useful for treating a variety of cosmetic conditions and dermatological disorders, where the composition includes a phenyl glycine derivative represented by the following formula: wherein, R1 and R2 are independently H, I, F, Cl, Br, OH, SH, NH2, NHNH2, alkyl, aralkyl, alkoxy, acetoxy, acyloxy group having 1 to 9 carbon atoms, and being attached at the 2, 3 or 4 position of the phenyl group, whereby when R1 and/or R2 are OH, SH, NH2, they may be acetylated or acylated with 1 to 9 carbon atoms; R3 is H, formyl, acetyl, propanoyl, acyl, alkyl, aralkyl or an aryl group having 1 to 9 carbon atoms; R4 is OH, NH2, NHOH, NHNH2, or OR; where R is an alkyl, aralkyl or aryl group having 1 to 9 carbon atoms; the H attached to any carbon or nitrogen atom may be substituted by I, F, Cl, Br, OH, SH, NH2, NHNH2, an alkyl, aralkyl, alkoxy or acyl group having 1 to 9 carbon atoms. Phenyl-glycine and its derivatives may be present as isomeric D or L, non-isomeric or racemic DL, as a free acid, salt, lactone, amide or ester form.

    摘要翻译： 本发明涉及可用于治疗各种美容条件和皮肤疾病的组合物和方法，其中组合物包含由下式表示的苯基甘氨酸衍生物：其中，R 1和R 2独立地为H，I，F，Cl，Br， OH，SH，NH 2，NHNH 2，烷基，芳烷基，烷氧基，乙酰氧基，具有1至9个碳原子的酰氧基，并且在苯基的2,3或4位上连接，由此当R 1和/或R 2为OH ，SH，NH 2，它们可以被1至9个碳原子乙酰化或酰化; R3是H，甲酰基，乙酰基，丙酰基，酰基，烷基，芳烷基或具有1至9个碳原子的芳基; R4是OH，NH2，NHOH，NHNH2或OR; 其中R是具有1至9个碳原子的烷基，芳烷基或芳基; 可以被I，F，Cl，Br，OH，SH，NH 2，NHNH 2，具有1至9个碳原子的烷基，芳烷基，烷氧基或酰基所取代的任何碳原子或氮原子上的H。 苯基甘氨酸及其衍生物可以作为游离酸，盐，内酯，酰胺或酯形式存在为异构体D或L，非异构体或外消旋DL。