公开(公告)号：US10071842B2

公开(公告)日：2018-09-11

申请号：US15394147

申请日：2016-12-29

申请人： Robert J. Jones ,  Michael R. Jones

发明人： Robert J. Jones ,  Michael R. Jones

IPC分类号： B65D5/10 ,  B65D5/56 ,  B65D77/06 ,  B65D5/42 ,  B65D5/62 ,  B65D5/44 ,  B65D5/00 ,  B31B7/26 ,  B31B1/26 ,  B31B1/60

CPC分类号： B65D77/061 ,  B31B50/26 ,  B31B50/262 ,  B31B50/46 ,  B31B50/48 ,  B31B50/60 ,  B31B50/734 ,  B31B2105/00 ,  B31B2110/40 ,  B31B2120/40 ,  B65D5/106 ,  B65D5/62

摘要： A collapsible bulk material container apparatus, kit and method of assembly employ a forming member having a plurality of interconnected sidewalls, a locking mechanism that fixedly orients the sidewalls continuously about an internal bulk material receiving cavity, and a tubular open-ended woven fabric sleeve that supportively overlies the sidewalls. A connector system rapidly engageable during container assembly, fixedly secures the support sleeve of an unloaded container against subsequent upward movement along the sidewalls. Strategically located friction reducing surfaces of the forming member facilitates sliding assembly of the sleeve over the forming member sidewalls.

公开(公告)号：US09358121B2

公开(公告)日：2016-06-07

申请号：US11684608

申请日：2007-03-10

申请人： Christopher Chaput ,  Robert J. Jones

发明人： Christopher Chaput ,  Robert J. Jones

IPC分类号： A61F2/44 ,  A61F2/30

CPC分类号： A61F2/4425 ,  A61F2002/30224 ,  A61F2002/30331 ,  A61F2002/30365 ,  A61F2002/30369 ,  A61F2002/30484 ,  A61F2002/305 ,  A61F2002/30507 ,  A61F2002/30578 ,  A61F2002/30607 ,  A61F2002/30616 ,  A61F2002/30662 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/30894 ,  A61F2002/3092 ,  A61F2002/443 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2230/0069 ,  A61F2250/0062 ,  A61F2310/00011

摘要： An apparatus and method is provided relating to artificial discs. An artificial disc is provided that facilitates simultaneous and independent articulation of flexion/extension, lateral bending, anterior/posterior translation, and axial rotation. The artificial disc provides these four simultaneous and independent articulations by independently addressing each type of articulation in the design of the artificial disc. In one example, an artificial disc is comprised of a bearing disposed between first and second end plates. The bearing is movable relative to each end plate, independent of the other end plate. The end plates are affixed to adjacent vertebrae.

摘要翻译： 提供了关于人造盘的装置和方法。 提供了一种人造盘，其有助于同时且独立地进行屈曲/伸展，侧向弯曲，前/后平移和轴向旋转。 人造盘通过独立地处理人造盘的设计中的每种类型的关节来提供这四个同时且独立的关节。 在一个示例中，人造盘由设置在第一和第二端板之间的轴承构成。 轴承相对于每个端板是可移动的，与另一个端板无关。 端板固定在相邻的椎骨上。

公开(公告)号：US09241810B1

公开(公告)日：2016-01-26

申请号：US13135675

申请日：2011-07-12

申请人： Mustasim Rumi ,  Robert J. Jones ,  Richard Kana ,  John Rossman

发明人： Mustasim Rumi ,  Robert J. Jones ,  Richard Kana ,  John Rossman

IPC分类号： A61F2/44

CPC分类号： A61F2/447 ,  A61F2/44 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/2835 ,  A61F2002/30014 ,  A61F2002/30387 ,  A61F2002/305 ,  A61F2002/30841 ,  A61F2002/4475

摘要： An interbody fusion device for fusion of vertebrae, and methods thereof. The device includes a first piece made of titanium having upper and lower surfaces configured to engage the endplates of two opposing vertebrae. The upper and lower surfaces include a plurality of barbed teeth configured to engage an endplate. The first piece includes an inner void area configured to receive a second piece. The second piece is configured to engage the first piece to slide over inner surfaces of the first piece become seated and mated in the first piece. The first and second pieces mate to form an assembled interbody fusion device that fits between two vertebrae.

摘要翻译： 用于椎骨融合的椎体间融合装置及其方法。 该装置包括由钛制成的第一件，其具有被配置为接合两个相对的椎骨的端板的上表面和下表面。 上表面和下表面包括构造成接合端板的多个倒钩齿。 第一件包括构造成接收第二件的内部空隙区域。 第二部件构造成使第一部件接合以在第一部件的内表面上滑动在第一部件中就座并配合。 第一和第二部分配合形成组装的两个椎骨之间的体内融合装置。

公开(公告)号：US08636743B2

公开(公告)日：2014-01-28

申请号：US13486232

申请日：2012-06-01

申请人： Robert J. Jones ,  Charles R. Forton

发明人： Robert J. Jones ,  Charles R. Forton

IPC分类号： A61B17/88

CPC分类号： A61B17/8866 ,  A61B17/025 ,  A61B17/16 ,  A61B17/1655 ,  A61B17/1757 ,  A61B17/7002 ,  A61B17/7011 ,  A61B17/7032 ,  A61B17/7037 ,  A61B17/7079 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7091 ,  A61B17/8605 ,  A61B17/861 ,  A61B17/8875 ,  A61B2017/0256 ,  A61B2090/037

摘要： A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

摘要翻译： 脊柱稳定系统可以形成在患者体内。 在一些实施例中，微创手术可用于在患者体内形成脊柱稳定系统。 骨头紧固件组件可以联接到椎骨。 每个骨紧固件组件可以包括骨紧固件和颈圈。 延伸器可以联接到套环以允许通过小皮肤切口形成脊柱稳定系统。 延伸器可以允许套环的对准以便于细长构件在套环中的插入。 细长构件可以定位在套环中，并且闭合构件可用于将细长构件固定到套环。 调节器可以与延伸器一起使用以改变骨紧固件组件之间的间隔距离。

公开(公告)号：US08075592B2

公开(公告)日：2011-12-13

申请号：US11764642

申请日：2007-06-18

申请人： Michael E. Landry ,  Larry T. Khoo ,  Erik J. Wagner ,  Charles R. Forton ,  Robert J. Jones

发明人： Michael E. Landry ,  Larry T. Khoo ,  Erik J. Wagner ,  Charles R. Forton ,  Robert J. Jones

IPC分类号： A61B17/70 ,  A61B17/88

CPC分类号： A61B17/7037 ,  A61B17/00234 ,  A61B17/1604 ,  A61B17/1655 ,  A61B17/1671 ,  A61B17/1703 ,  A61B17/1757 ,  A61B17/701 ,  A61B17/7011 ,  A61B17/7032 ,  A61B17/7035 ,  A61B17/708 ,  A61B17/7082 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7091 ,  A61B17/8605 ,  A61B17/861 ,  A61B17/8863 ,  A61B17/8866 ,  A61B17/8875 ,  A61B17/8897 ,  A61B2017/0256 ,  A61B2090/031 ,  A61B2090/037 ,  A61B2090/061 ,  A61B2090/062 ,  Y10S606/914

摘要： A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars.

摘要翻译： 脊柱稳定系统可以形成在患者体内。 在一些实施例中，微创手术可用于在患者体内形成脊柱稳定系统。 骨头紧固件组件可以联接到椎骨。 每个骨紧固件组件可以包括骨紧固件和颈圈。 轴环可以相对于骨紧固件旋转和/或成角度。 可拆卸构件可以联接到套环以允许通过小皮肤切口形成脊柱稳定系统。 可拆卸构件可以允许套环的对准以便于细长构件在套环中的插入。 细长构件可以定位在套环中，并且闭合构件可用于将细长构件固定到套环。

公开(公告)号：US20090149648A1

公开(公告)日：2009-06-11

申请号：US12211745

申请日：2008-09-16

申请人： Norbert W. Bischofberger ,  Robert J. Jones ,  Murty N. Armilli ,  Kuei-Ying Lin ,  Michael S. Louie ,  Lawrence R. McGee ,  Ernest J. Prisbe ,  William A. Lee ,  Kenneth C. Cundy

发明人： Norbert W. Bischofberger ,  Robert J. Jones ,  Murty N. Armilli ,  Kuei-Ying Lin ,  Michael S. Louie ,  Lawrence R. McGee ,  Ernest J. Prisbe ,  William A. Lee ,  Kenneth C. Cundy

IPC分类号： C07F9/02

CPC分类号： C07F9/657181 ,  C07F9/6512 ,  C07F9/65616 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/65785 ,  C07H19/10 ,  C07H19/20

摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

摘要翻译： 公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。 类似物包含在体内水解以产生相应的膦酸酯核苷酸类似物的氨基磷酸酯或酯键。 描述了其合成和使用的方法和中间体。

公开(公告)号：US07439350B2

公开(公告)日：2008-10-21

申请号：US10882022

申请日：2004-06-29

申请人： Norbert W. Bischofberger ,  Robert J. Jones ,  Murty N. Arimilli ,  Kuei-Ying Lin ,  Michael S. Louie ,  Lawrence R. McGee ,  Ernest J. Prisbe ,  William A. Lee ,  Kenneth C. Cundy

发明人： Norbert W. Bischofberger ,  Robert J. Jones ,  Murty N. Arimilli ,  Kuei-Ying Lin ,  Michael S. Louie ,  Lawrence R. McGee ,  Ernest J. Prisbe ,  William A. Lee ,  Kenneth C. Cundy

IPC分类号： C07H19/04

CPC分类号： C07F9/657181 ,  C07F9/6512 ,  C07F9/65616 ,  C07F9/65742 ,  C07F9/65744 ,  C07F9/65785 ,  C07H19/10 ,  C07H19/20

摘要： Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

摘要翻译： 公开了以与磷酸酯核苷酸类似物的磷原子结合的氨基酸连接的氨基酸或酯连接基团的存在为特征的核苷酸类似物。 类似物包含在体内水解以产生相应的膦酸酯核苷酸类似物的氨基磷酸酯或酯键。 描述了其合成和使用的方法和中间体。

公开(公告)号：US07250052B2

公开(公告)日：2007-07-31

申请号：US10697793

申请日：2003-10-30

申请人： Michael E. Landry ,  Larry T. Khoo ,  Erik J. Wagner ,  Charles R. Forton ,  Robert J. Jones

发明人： Michael E. Landry ,  Larry T. Khoo ,  Erik J. Wagner ,  Charles R. Forton ,  Robert J. Jones

IPC分类号： A61B17/56

CPC分类号： A61B17/7037 ,  A61B17/00234 ,  A61B17/1604 ,  A61B17/1655 ,  A61B17/1671 ,  A61B17/1703 ,  A61B17/1757 ,  A61B17/701 ,  A61B17/7011 ,  A61B17/7032 ,  A61B17/7035 ,  A61B17/708 ,  A61B17/7082 ,  A61B17/7083 ,  A61B17/7085 ,  A61B17/7091 ,  A61B17/8605 ,  A61B17/861 ,  A61B17/8863 ,  A61B17/8866 ,  A61B17/8875 ,  A61B17/8897 ,  A61B2017/0256 ,  A61B2090/031 ,  A61B2090/037 ,  A61B2090/061 ,  A61B2090/062 ,  Y10S606/914

摘要： A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars.

摘要翻译： 脊柱稳定系统可以形成在患者体内。 在一些实施例中，微创手术可用于在患者体内形成脊柱稳定系统。 骨头紧固件组件可以联接到椎骨。 每个骨紧固件组件可以包括骨紧固件和颈圈。 轴环可以相对于骨紧固件旋转和/或成角度。 可拆卸构件可以联接到套环以允许通过小皮肤切口形成脊柱稳定系统。 可拆卸构件可以允许套环的对准以便于细长构件在套环中的插入。 细长构件可以定位在套环中，并且闭合构件可用于将细长构件固定到套环。

公开(公告)号：US06380368B1

公开(公告)日：2002-04-30

申请号：US08599738

申请日：1996-02-12

申请人： Brian Froehler ,  Rick Wagner ,  Mark Mattencci ,  Robert J. Jones ,  Arnold J. Gutierrez ,  Jeff Pudlo

发明人： Brian Froehler ,  Rick Wagner ,  Mark Mattencci ,  Robert J. Jones ,  Arnold J. Gutierrez ,  Jeff Pudlo

IPC分类号： C07H2102

CPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/6839 ,  C12Q2525/101

摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.

摘要翻译： 公开了与仅含有常规碱的低聚物相比，具有增强形成双链体或三链体的能力的新型低聚物。 低聚物含有5-（1-丙炔基）尿嘧啶，5-（1-丙炔基）胞嘧啶或相关类似物的碱基。 本发明的寡聚体能够（i）通过在生理pH下偶联到目标DNA双链体的主要沟槽中或（ii）通过结合单链DNA形成双链体，形成具有各种靶序列的病毒或致癌基因序列的三链体 或由靶基因编码的RNA。 本发明的寡聚体可以并入药学上可接受的载体中，并且可以被构建成具有任何所需的序列，条件是序列通常包括用本发明的类似物代替的一个或多个碱基。 本发明的组合物可以用作药剂来治疗由病毒引起的各种疾病，并且可以用于诊断目的以检测病毒或疾病状况。

公开(公告)号：US06235887B1

公开(公告)日：2001-05-22

申请号：US08338352

申请日：1994-11-14

申请人： Brian Froehler ,  Robert J. Jones

发明人： Brian Froehler ,  Robert J. Jones

IPC分类号： C07H2102

CPC分类号： C07H19/06 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/6839 ,  C12Q2525/101

摘要： Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the base analog 5-propynyluracil, 5-propynylcytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention may be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used for diagnostic purposes in order to detect viruses or disease conditions.

摘要翻译： 公开了与仅含有常规碱的低聚物相比，具有增强形成双链体或三链体的能力的新型低聚物。 寡聚体包含碱基类似物5-丙炔基尿嘧啶，5-丙炔基胞嘧啶或相关类似物。 本发明的寡聚体能够（i）通过在生理pH下偶联到目标DNA双链体的主要沟槽中或（ii）通过结合单链DNA形成双链体，形成具有各种靶序列的病毒或致癌基因序列的三链体 或由靶基因编码的RNA。 本发明的寡聚体可以构建成具有任何所需的序列，条件是该序列通常包括被本发明的类似物替代的一个或多个碱基。 本发明的组合物可用于诊断目的以检测病毒或疾病状况。