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公开(公告)号：US09308301B2
公开(公告)日：2016-04-12
申请号：US13089960
申请日：2011-04-19
申请人： Syed H. Askari , Robert G. Whirley
发明人： Syed H. Askari , Robert G. Whirley
CPC分类号： A61L31/06 , A61K49/0404 , A61K49/0457 , A61L24/0031 , A61L31/145 , A61L31/18 , A61L2430/36
摘要： Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.
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公开(公告)号：US08900288B2
公开(公告)日：2014-12-02
申请号：US12566104
申请日：2009-09-24
CPC分类号： A61F2/07 , A61F2/82 , A61F2/844 , A61F2/89 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91558 , A61F2002/91583 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/005 , A61F2220/0058 , A61F2250/0003 , A61F2250/0036 , A61M2025/0177
摘要： This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.
摘要翻译： 本发明是一种用于治疗身体通道的系统; 特别是具有血管疾病的血管。 该系统包括具有低轮廓输送配置的血管内移植物和展开构造，其中它符合要治疗的血管或身体通道以及各种连接器构件和支架的形态。 移植物由可膨胀的移植物体部分制成并且可以分叉。 一个或多个可充气袖口可以设置在移植物主体部分的任一端。 至少一个充气通道设置在可膨胀的袖口之间并且与可膨胀的袖口流体连通。
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公开(公告)号：US07766954B2
公开(公告)日：2010-08-03
申请号：US11333595
申请日：2006-01-17
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/844 , A61F2/89 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/962 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/825 , A61F2002/8486 , A61F2002/91508 , A61F2002/91516 , A61F2002/91558 , A61F2002/91583 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2220/005 , A61F2220/0058 , A61F2250/0003 , A61F2250/0036 , A61M2025/0177
摘要： This invention is a system for the treatment of body passageways; in particular, vessels with vascular disease. The system includes an endovascular graft with a low-profile delivery configuration and a deployed configuration in which it conforms to the morphology of the vessel or body passageway to be treated as well as various connector members and stents. The graft is made from an inflatable graft body section and may be bifurcated. One or more inflatable cuffs may be disposed at either end of the graft body section. At least one inflatable channel is disposed between and in fluid communication with the inflatable cuffs.
摘要翻译： 本发明是一种用于治疗身体通道的系统; 特别是具有血管疾病的血管。 该系统包括具有低轮廓输送配置的血管内移植物和展开构造，其中它符合要治疗的血管或身体通道以及各种连接器构件和支架的形态。 移植物由可膨胀的移植物体部分制成并且可以分叉。 一个或多个可充气袖口可以设置在移植物主体部分的任一端。 至少一个充气通道设置在可膨胀的袖口之间并且与可膨胀的袖口流体连通。
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公开(公告)号：US08267989B2
公开(公告)日：2012-09-18
申请号：US12860364
申请日：2010-08-20
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/0095 , A61F2/06 , A61F2/89 , A61F2002/075 , A61F2250/0003 , A61F2250/0023 , A61F2250/0035 , A61F2250/0068 , A61L27/507 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/42
摘要： The present invention provides inflatable porous implants, such as grafts, stent-grafts, and bladders, as well as methods and kits for drug delivery. In particular, the grafts and stent-grafts of the present invention provide for the delivery of a therapeutic agent into a flow conduit in the body. The inflatable porous implants provide for direct delivery of larger, more precise dosages of drugs over longer administration periods into the body. Moreover, these inflatable porous implants are often flexible when inserted and have a low profile delivery configuration for easy placement. The implants of the present invention further provide a mechanical or structural function in addition to drug delivery in a single integrated structure.
摘要翻译： 本发明提供了可膨胀的多孔植入物，例如移植物，支架移植物和囊，以及用于药物递送的方法和试剂盒。 特别地，本发明的移植物和支架移植物提供将治疗剂递送到体内的流动导管中。 可膨胀的多孔植入物可在更长的施用期内直接递送更大，更精确的药物剂量进入体内。 此外，这些可膨胀的多孔植入物在插入时通常是柔性的，并且具有便于放置的低轮廓输送构型。 本发明的植入物除了在单个整体结构中的药物递送之外还提供机械或结构功能。
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公开(公告)号：US20110218609A1
公开(公告)日：2011-09-08
申请号：US13024255
申请日：2011-02-09
申请人： Michael V. Chobotov , Mary Jane Marston , Mark E, Purter , Patrick Stephens , James R. Watson , Robert G. Whirley
发明人： Michael V. Chobotov , Mary Jane Marston , Mark E, Purter , Patrick Stephens , James R. Watson , Robert G. Whirley
CPC分类号： A61F2/06 , A61B6/4441 , A61B6/487 , A61F2/966 , A61F2002/065 , A61F2250/0003 , A61F2250/0098 , A61L31/022 , A61L31/048 , A61L31/18 , A61L2400/16 , A61M2025/0681 , C08L27/18
摘要： Some embodiments relate in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to inflatable stent grafts and methods of positioning and deploying such devices within the body of a patient. Some embodiments include inflation devices and methods that allow an inflatable portion of an inflatable stent graft to be inflated from a desired location within the inflatable portion.
摘要翻译： 一些实施例部分地涉及血管内假体及其部署方法。 实施例可以更具体地涉及可充气支架移植物以及将这样的装置定位和部署在患者体内的方法。 一些实施例包括充气装置和方法，其允许可充气支架移植物的可膨胀部分从可充气部分内的期望位置膨胀。
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6.发明申请公开(公告)号：US20110196060A1
公开(公告)日：2011-08-11
申请号：US13089960
申请日：2011-04-19
申请人： Syed H. Askari , Robert G. Whirley
发明人： Syed H. Askari , Robert G. Whirley
IPC分类号： A61L27/52
CPC分类号： A61L31/06 , A61K49/0404 , A61K49/0457 , A61L24/0031 , A61L31/145 , A61L31/18 , A61L2430/36
摘要： Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.
摘要翻译： 提供由胺组分和缩水甘油醚组分制备的水凝胶组合物，其生物相容性并且适于在体内使用，部分是由于其优异的稳定性。
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公开(公告)号：US20110029297A1
公开(公告)日：2011-02-03
申请号：US12904994
申请日：2010-10-14
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译： 开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。 该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。 在一个实施例中，几何生成器接收解剖特征的三维体积数据并生成几何模型。 然后，网格生成器接收解剖特征或候选医疗装置的体外模型和几何模型的几何模型。 在另一个实施例中，网格生成器仅接收候选医疗设备的几何模型。 使用接收的几何模型，网格生成器创建或生成网格或有限元模型。 应力/应变/变形分析仪接收网格，以及该网格的材料模型和载荷。 使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。 可以使用可视化工具任意地模拟这种应力，应变和变形。
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公开(公告)号：US07840393B1
公开(公告)日：2010-11-23
申请号：US09679725
申请日：2000-10-04
IPC分类号： G06G7/48
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. In one embodiment, the geometry generator receives three-dimensional volumetric data of an anatomical feature and generates a geometric model. The mesh generator then receives such geometric model of an anatomical feature or an in vitro model and a geometric model of a candidate medical device. In another embodiment, the mesh generator only receives a geometric model of the candidate medical device. Using the geometric model(s) received, the mesh generator creates or generates a mesh or a finite element model. The stress/strain/deformation analyzer then receives the mesh, and the material models and loads of that mesh. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译： 开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。 该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。 在一个实施例中，几何生成器接收解剖特征的三维体积数据并生成几何模型。 然后，网格生成器接收解剖特征或候选医疗装置的体外模型和几何模型的几何模型。 在另一个实施例中，网格生成器仅接收候选医疗设备的几何模型。 使用接收的几何模型，网格生成器创建或生成网格或有限元模型。 应力/应变/变形分析仪接收网格，以及该网格的材料模型和载荷。 使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。 可以使用可视化工具任意地模拟这种应力，应变和变形。
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公开(公告)号：US07803178B2
公开(公告)日：2010-09-28
申请号：US10769532
申请日：2004-01-30
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/0095 , A61F2/06 , A61F2/89 , A61F2002/075 , A61F2250/0003 , A61F2250/0023 , A61F2250/0035 , A61F2250/0068 , A61L27/507 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/42
摘要： The present invention provides inflatable porous implants, such as grafts, stent-grafts, and bladders, as well as methods and kits for drug delivery. In particular, the grafts and stent-grafts of the present invention provide for the delivery of a therapeutic agent into a flow conduit in the body. The inflatable porous implants provide for direct delivery of larger, more precise dosages of drugs over longer administration periods into the body. Moreover, these inflatable porous implants are often flexible when inserted and have a low profile delivery configuration for easy placement. The implants of the present invention further provide a mechanical or structural function in addition to drug delivery in a single integrated structure.
摘要翻译： 本发明提供了可膨胀的多孔植入物，例如移植物，支架移植物和囊，以及用于药物递送的方法和试剂盒。 特别地，本发明的移植物和支架移植物提供将治疗剂递送到体内的流动导管中。 可膨胀的多孔植入物可在更长的施用期内直接递送更大，更精确的药物剂量进入体内。 此外，这些可膨胀的多孔植入物在插入时通常是柔性的，并且具有便于放置的低轮廓输送构型。 本发明的植入物除了在单个整体结构中的药物递送之外还提供机械或结构功能。
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公开(公告)号：US20120316854A1
公开(公告)日：2012-12-13
申请号：US13523765
申请日：2012-06-14
IPC分类号： G06F17/50
摘要： A system and method of developing better-designed medical devices, particularly cardiovascular stents and endovascular grafts. The system comprises a geometry generator, a mesh generator, a stress/strain/deformation analyzer, and a visualization tool. Using analysis, preferably non-linear analysis, the stress/strain/deformation analyzer determines the predicted stresses, strains, and deformations on the candidate medical device. Such stresses, strains, and deformations may optionally be simulated visually using a visualization tool.
摘要翻译： 开发更好设计的医疗设备，特别是心血管支架和血管内移植物的系统和方法。 该系统包括几何生成器，网格发生器，应力/应变/变形分析器和可视化工具。 使用分析，优选非线性分析，应力/应变/变形分析仪确定候选医疗设备上预测的应力，应变和变形。 可以使用可视化工具任意地模拟这种应力，应变和变形。
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