知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

21 records (took 0.017 seconds)

    Cyanine Dye Labelling Reagents
    1.
    发明申请
    Cyanine Dye Labelling Reagents 失效
    花青染料标签试剂

    公开(公告)号：US20100267937A1

    公开(公告)日：2010-10-21

    申请号：US12828391

    申请日：2010-07-01

    Applicant: Richard M. West ,  Nigel Bosworth ,  Ratnakar B. Mujumdar

    Inventor： Richard M. West ,  Nigel Bosworth ,  Ratnakar B. Mujumdar

    IPC: C07K16/00 ,  C07D403/06 ,  C07D209/10 ,  C07H19/10 ,  C07H21/04

    CPC classification number: C09B23/02 ,  C07D209/10 ,  C07D209/24 ,  C07D403/06 ,  C07D403/08

    Abstract: Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the carbon atoms necessary to complete a one ring, or two-fused ring aromatic system; at least one of groups R1, R2, R3, R4, R5, R6 and R7 is the group -E-F where E is a single bond or a spacer group and F is a target bonding group; one or more of groups R11, R12, R13 and R14 are independently selected from the group —(CH2)k—W, where W is sulphonic acid or phosphonic acid and k is an integer from 1 to 10. The dyes may be used in fluorescence labelling applications, where the presence of one and preferably multiple water solubilising groups attached to the 3-position of the indolinium ring reduces dye-dye interactions, and hence dye-dye quenching, particularly where multiple dye molecules are attached to components such as nucleic acids, oligonucleotides, proteins and antibodies.

    Abstract translation: 公开了可用于标记和检测生物和其他材料的花青染料。 染料具有式（I）：其中基团R 3和R 4连接到Z 1环结构，并且基团R 5和R 6连接到Z 2环结构，并且n = 1,2或3; Z 1和Z 2独立地表示完成一个环或双稠环芳族体系所必需的碳原子; 基团R 1，R 2，R 3，R 4，R 5，R 6和R 7中的至少一个是基团-E-F，其中E是单键或间隔基，F是目标键合基团; 基团R11，R12，R13和R14中的一个或多个独立地选自基团 - （CH 2）k-W，其中W是磺酸或膦酸，k是1至10的整数。染料可以用于 荧光标记应用，其中连接到吲哚啉环的3-位上的一个并且优选多个水溶性基团的存在降低了染料 - 染料相互作用，并因此染色剂猝灭，特别是当多个染料分子连接到组分如核酸 酸，寡核苷酸，蛋白质和抗体。

    Rigidized trimethine cyanine dyes
    3.
    发明授权
    Rigidized trimethine cyanine dyes 有权
    刚性三甲氰花青染料

    公开(公告)号：US6133445A

    公开(公告)日：2000-10-17

    申请号：US212564

    申请日：1998-12-16

    Applicant: Alan S. Waggoner ,  Ratnakar B. Mujumdar

    Inventor： Alan S. Waggoner ,  Ratnakar B. Mujumdar

    IPC: C07D471/22 ,  C07D491/22 ,  C07D493/22 ,  C07D513/22 ,  G01N33/533 ,  G01N33/542 ,  C07D221/22

    CPC classification number: C07D493/22 ,  C07D471/22 ,  C07D491/22 ,  C07D513/22 ,  G01N33/533 ,  G01N33/542

    Abstract: Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association. The compounds have the following general formula: ##STR1## optionally substituted by groups R.sup.2 -R.sup.9 wherein groups R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are attached to the rings containing X and Y or, optionally are attached to atoms of the Z.sup.a and Z.sup.b ring structures and groups R.sup.1 -R.sup.9 are chosen to provide desired solubility, reactivity and spectral properties to the fluorescent compounds;A is selected from O, S and NR.sup.11 where R.sup.11 is the substituted amino radical: ##STR2## where R' is selected from hydrogen, a C.sub.1-4 alkyl and aryl and R" is selected from C.sub.1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms, and a thiocarbamoyl radical; Z.sup.a and Z.sup.b each represent a bond or the atoms necessary to complete one, two fused or three fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, no more than two oxygen, nitrogen and sulphur atoms.

    Abstract translation: 公开了三聚氰胺染料的类似物，其可用于通过共价和非共价缔合赋予目标材料荧光性质。 化合物具有以下通式：任选地被基团R 2 -R 9取代，其中基团R 6，R 7，R 8和R 9连接到含有X和Y的环上，或任选被连接到Za和Zb环结构的原子上，并且基团R 1 选择-R9以为荧光化合物提供所需的溶解度，反应性和光谱性质; A选自O，S和NR 11，其中R 11是取代的氨基：其中R'选自氢，C 1-4烷基和芳基，R“选自C 1-18烷基，芳基，杂芳基，酰基 具有2-7个碳原子的基团和一个硫代氨基甲酰基; Za和Zb各自表示一个键或完成一个，两个稠合或三个稠合芳环所必需的原子，每个环具有五个或六个原子，选自碳原子和任选不超过两个氧，氮和硫原子。

    Rigidized trimethine cyanine dyes
    6.
    发明授权
    Rigidized trimethine cyanine dyes 有权
    刚性三甲氰花青染料

    公开(公告)号：US06686145B1

    公开(公告)日：2004-02-03

    申请号：US09581679

    申请日：2000-07-25

    Applicant: Alan S. Waggoner ,  Ratnakar B. Mujumdar

    Inventor： Alan S. Waggoner ,  Ratnakar B. Mujumdar

    IPC: C12Q170

    CPC classification number: G01N33/582 ,  C07D471/22 ,  C07D491/22 ,  C09B23/0075 ,  C09B23/06

    Abstract: Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association. The compounds have general formula (2) optionally substituted by groups R2-R9 wherein groups R6, R7, R8 and R9 are attached to the rings containing X and Y or, optionally are attached to atoms of the Za and Zb ring structures and groups R1-R9 are chosen to provide desired solubility, reactivity and spectralproperties to the fluorescent compounds; A is selected from O, S and NR11 where R11 is the substituted amino radical (a), where R′ is selected from hydrogen, a C1-4 alkyl and aryl and R″ is selected from C1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms, and a thiocarbamoyl radical; Za and Zb each represent a bond or the atoms necessary to complete one, two fused or three fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, non more than two oxygen, nitrogen and sulphur atoms.

    Abstract translation: 公开了三聚氰胺染料的类似物，其可用于通过共价和非共价缔合赋予目标材料荧光性质。 化合物具有任选被基团R 2 -R 9取代的通式（2），其中基团R 6，R 7，R 8和R 9连接到含有X的环和 Y或任选地连接到Z 1和Z 2环结构的原子上，并且选择基团R 1 -R 9以提供对荧光化合物的期望的溶解度，反应性和光谱性质; A选自O，S和NR 11，其中R 11是取代的氨基（a），其中R'选自氢，C1-4烷基和芳基，R“选自C1- 18烷基，芳基，杂芳基，具有2-7个碳原子的酰基和硫代氨基甲酰基; Z'和Z'各自表示一个键或完成一个，两个稠合或三个稠合芳环所必需的原子，每个环具有五个或六个原子，选自碳原子和任选地不多于两个氧， 氮和硫原子。

    Rigidized monomethine cyanines
    8.
    发明授权
    Rigidized monomethine cyanines 失效
    刚性单甲氰菊酯

    公开(公告)号：US06207464B1

    公开(公告)日：2001-03-27

    申请号：US09143070

    申请日：1998-08-28

    Applicant: Bhalchandra M. Karandikar ,  Alan S. Waggoner ,  Ratnakar B. Mujumdar

    Inventor： Bhalchandra M. Karandikar ,  Alan S. Waggoner ,  Ratnakar B. Mujumdar

    IPC: G01N33533

    CPC classification number: G01N33/533 ,  C09B23/0075 ,  C09B23/04 ,  C09B57/00 ,  Y10S436/80

    Abstract: Boron complexes of certain bis-heterocyclic compounds are provided. The complexes resemble monomethine cyanines and are useful for imparting fluorescent properties to materials by covalent and noncovalent association. The compounds have the following general formula: wherein the dotted lines Z1 and Z2 represent the atoms necessary to complete a structure selected from the group consisting of one ring, two fused rings, and three fused rings, each said ring having five or six atoms, and each said ring comprising carbon atoms and, optionally, no more than two atoms selected from oxygen, nitrogen and sulfur, and R1 through R5 represent various atoms or groups and M is Cl or F.

    Abstract translation: 提供某些双杂环化合物的硼配合物。 复合物类似于单甲基花青，可用于通过共价和非共价缔合赋予材料荧光性质。 这些化合物具有以下通式：其中虚线Z1和Z2表示完成选自一个环，两个稠环和三个稠合环的结构所必需的原子，每个所述环具有五个或六个原子， 并且每个所述环包含碳原子和任选不超过两个选自氧，氮和硫的原子，并且R 1至R 5表示各种原子或基团，M是Cl或F.

Patent Agency Ranking