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公开(公告)号：US12098139B2
公开(公告)日：2024-09-24
申请号：US17750165
申请日：2022-05-20
发明人： Jeffrey J. Jackson , John Michael Ketcham , Akinori Okano , Maureen Kay Reilly , Omar Robles-Resendiz , Jacob Bradley Schwarz , Parcharee Tivitmahaisoon , David Juergen Wustrow , Ashkaan Younai , Mikhail Zibinsky
IPC分类号： C07D401/14 , A61P11/06 , A61P17/00 , A61P29/00 , A61P35/00 , C07D495/04
CPC分类号： C07D401/14 , A61P11/06 , A61P17/00 , A61P29/00 , A61P35/00 , C07D495/04
摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
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公开(公告)号：US20240199620A1
公开(公告)日：2024-06-20
申请号：US18389182
申请日：2023-11-13
发明人： Hilary Plake Beck , Berenger Biannic , Minna Hue Thanh Bui , Dennis X. Hu , John Michael Ketcham , Jay Patrick Powers , Maureen Kay Reilly , Omar Robles-Resendiz , Hunter Paul Shunatona , James Ross Walker , David Juergen Wustrow , Ashkaan Younai , Mikhail Zibinsky , Jeffrey J. Jackson
IPC分类号： C07D487/04 , A61K31/122 , A61K31/198 , A61K31/235 , A61K31/42 , A61K31/454 , A61K31/4706 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K31/593 , A61K31/7135 , A61K31/728 , A61K45/06
CPC分类号： C07D487/04 , A61K31/122 , A61K31/198 , A61K31/235 , A61K31/42 , A61K31/454 , A61K31/4706 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K31/593 , A61K31/7135 , A61K31/728 , A61K45/06
摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.
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公开(公告)号：US11730736B2
公开(公告)日：2023-08-22
申请号：US16181200
申请日：2018-11-05
IPC分类号： A61K31/4985 , A61P35/02 , A61K31/506 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/4985 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06
摘要： Disclosed herein are therapeutic methods of administering compounds that modulate the C—C chemokine receptor type 4 (CCR4) for the treatment of Epstein Bar virus (EBV) positive cancers and malignancies.
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公开(公告)号：US11384064B2
公开(公告)日：2022-07-12
申请号：US16859896
申请日：2020-04-27
发明人： Jeffrey J. Jackson , John Michael Ketcham , Akinori Okano , Maureen Kay Reilly , Omar Robles-Resendiz , Jacob Bradley Schwarz , Parcharee Tivitmahaisoon , David Juergen Wustrow , Ashkaan Younai , Mikhail Zibinsky
IPC分类号： C07D401/14 , C07D495/04 , A61P17/00 , A61P11/06 , A61P35/00 , A61P29/00
摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
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公开(公告)号：US20220305018A1
公开(公告)日：2022-09-29
申请号：US17694642
申请日：2022-03-14
发明人： Cyril Bucher , Adrian Dukes , Blanca Gomez , Hannah Haley , Dennis Hu , Jeffrey J. Jackson , Michelle Yoo Min Ko , Paul Leger , Anqi Ma , Andrew A. Ng , Daniel Poon , Omar Robles , Anton Shakhmin , Grant Shibuya , Parcharee Tivitmahaisoon , Vi-Anh Vu , David J. Wustrow , Mikhail Zibinsky
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00
摘要： Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.
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公开(公告)号：US20210317134A1
公开(公告)日：2021-10-14
申请号：US16810376
申请日：2020-03-05
发明人： Jacob Bradley Schwarz , John Michael Ketcham , Maureen Kay Reilly , Berenger Biannic , Minna Hue Thanh Bui , Dennis X. Hu , David Juergen Wustrow , Emily Karbarz , Xinping Han , Grant Shibuya , Jack Maung , Maksim Osipov
IPC分类号： C07D495/04 , C07D491/048 , C07D405/14 , C07D471/04 , C07D519/00 , C07D498/04
摘要： Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
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公开(公告)号：US10683280B2
公开(公告)日：2020-06-16
申请号：US16256987
申请日：2019-01-24
发明人： Jeffrey J. Jackson , John Michael Ketcham , Akinori Okano , Maureen Kay Reilly , Omar Robles-Resendiz , Jacob Bradley Schwarz , Parcharee Tivitmahaisoon , David Juergen Wustrow , Ashkaan Younai , Mikhail Zibinsky
IPC分类号： C07D401/14 , A61K31/506 , C07D495/04 , A61P17/00 , A61P11/06 , A61P35/00 , A61P29/00
摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
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公开(公告)号：US20200095260A1
公开(公告)日：2020-03-26
申请号：US16578276
申请日：2019-09-20
发明人： Berenger Biannic , Xinping Han , Dennis X. Hu , Paul Robert Leger , Jack Maung , Akinori Okano , Jacob Bradley Schwarz , David Juergen Wustrow , Kyle Young , Gene Cutler , Yamini Ohol-Gupta
IPC分类号： C07D495/04 , A61P35/02
摘要： Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
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公开(公告)号：US11918582B2
公开(公告)日：2024-03-05
申请号：US17694642
申请日：2022-03-14
发明人： Cyril Bucher , Adrian Dukes , Blanca Gomez , Hannah Haley , Dennis Hu , Jeffrey J. Jackson , Michelle Yoo Min Ko , Paul Leger , Anqi Ma , Andrew A. Ng , Daniel Poon , Omar Robles , Anton Shakhmin , Grant Shibuya , Parcharee Tivitmahaisoon , Vi-Anh Vu , David J. Wustrow , Mikhail Zibinsky
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D519/00
摘要： Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.
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公开(公告)号：US20220251070A1
公开(公告)日：2022-08-11
申请号：US17588173
申请日：2022-01-28
发明人： Cyril Bucher , James P. Davidson , Jeffrey J. Jackson , Michelle Yoo Min Ko , Grant Shibuya , David J. Wustrow , Ashkaan Younai , Mikhail Zibinsky
IPC分类号： C07D401/14 , C07D401/04 , C07D495/04
摘要： Disclosed herein, inter alia, methods of synthesis of trans isomeric forms of G protein-coupled receptor modulators of high trans isomeric purity.
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