公开(公告)号：US20220305018A1

公开(公告)日：2022-09-29

申请号：US17694642

申请日：2022-03-14

申请人： RAPT Therapeutics, Inc.

发明人： Cyril Bucher ,  Adrian Dukes ,  Blanca Gomez ,  Hannah Haley ,  Dennis Hu ,  Jeffrey J. Jackson ,  Michelle Yoo Min Ko ,  Paul Leger ,  Anqi Ma ,  Andrew A. Ng ,  Daniel Poon ,  Omar Robles ,  Anton Shakhmin ,  Grant Shibuya ,  Parcharee Tivitmahaisoon ,  Vi-Anh Vu ,  David J. Wustrow ,  Mikhail Zibinsky

IPC分类号： A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.

公开(公告)号：US11918582B2

公开(公告)日：2024-03-05

申请号：US17694642

申请日：2022-03-14

申请人： RAPT Therapeutics, Inc.

发明人： Cyril Bucher ,  Adrian Dukes ,  Blanca Gomez ,  Hannah Haley ,  Dennis Hu ,  Jeffrey J. Jackson ,  Michelle Yoo Min Ko ,  Paul Leger ,  Anqi Ma ,  Andrew A. Ng ,  Daniel Poon ,  Omar Robles ,  Anton Shakhmin ,  Grant Shibuya ,  Parcharee Tivitmahaisoon ,  Vi-Anh Vu ,  David J. Wustrow ,  Mikhail Zibinsky

IPC分类号： A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

CPC分类号： A61K31/519 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： Disclosed herein are pyrazole pyrimidine compounds that modulate and/or inhibit hematopoietic progenitor kinase 1, as well as methods of making such compounds and therapeutic methods of using same.