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1.发明授权Metapneumovirus strains and their use in vaccine formulations and sequences 有权肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体公开(公告)号：US08722341B2
公开(公告)日：2014-05-13
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Bernadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： Provided is an isolated mammalian negative strand RNA virus, metapneumovirus (MPV). Described are isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. Also described is mammalian MPV, subgroups and variants thereof, and genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods is provided. Nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus are described. Also provided are chimeric or recombinant viruses encoded by said nucleotide sequences and chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences.
摘要翻译： 提供了分离的哺乳动物负链RNA病毒，偏肺病毒（MPV）。 描述的是分离的哺乳动物负链RNA病毒，其被鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 还描述了哺乳动物MPV，亚组及其变体，以及哺乳动物偏肺病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 提供了用于诊断和治疗方法的哺乳动物偏肺炎病毒的不同分离株的序列信息的使用。 描述了编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 还提供了由所述核苷酸序列编码的嵌合或重组病毒以及包含一个或多个非天然或异源序列的嵌合和重组哺乳动物MPV。
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公开(公告)号：US20110045023A1
公开(公告)日：2011-02-24
申请号：US12855885
申请日：2010-08-13
申请人： HONG JIN , RODERICK TANG , SHENGQIANG LI , MARTIN BRYANT , DAVID KIRKWOOD CLARKE , PETER PALESE
发明人： HONG JIN , RODERICK TANG , SHENGQIANG LI , MARTIN BRYANT , DAVID KIRKWOOD CLARKE , PETER PALESE
IPC分类号： A61K39/155 , C12N7/04 , C07H21/04 , A61K35/76 , A61K31/7088 , A61P37/04 , A61P31/14
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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3.发明申请Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences 有权肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体公开(公告)号：US20100143407A1
公开(公告)日：2010-06-10
申请号：US12319152
申请日：2008-12-31
申请人： Ronaldus Adrianus Maria Fouchier , Benadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Adrianus Maria Fouchier , Benadetta Gerarda Van Den Hoogen , Albertus Dominicus Marcellinus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
CPC分类号： C12Q1/701 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K16/1027 , C12N7/00 , C12N15/86 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12N2760/18622 , C12N2840/203 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091 , G01N33/56983
摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations.
摘要翻译： 本发明提供分离的哺乳动物负链RNA病毒，亚型家族肺炎链球菌中的亚型副粘病毒亚科病毒（MPV）。 本发明还提供可分离的哺乳动物负链RNA病毒，其可鉴定为与肺炎病毒属及其组分相关或与之相关的系统发育。 特别地，本发明提供哺乳动物MPV，亚组及其变体。 本发明涉及哺乳动物偏肺炎病毒，特别是人类偏肺病毒的不同分离物的基因组核苷酸序列。 本发明涉及用于诊断和治疗方法的哺乳动物偏肺病毒的不同分离株的序列信息的使用。 本发明涉及编码偏肺病毒或其部分基因组的核苷酸序列，包括哺乳动物和禽类间质肺病毒。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 本发明还涉及包含一种或多种非天然或异源序列的嵌合和重组哺乳动物MPV。 本发明还涉及包含哺乳动物或禽类偏肺病毒的疫苗制剂，包括所述病毒的重组和嵌合形式。 本发明的疫苗制剂包括多价疫苗，包括二价和三价疫苗制剂。
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公开(公告)号：US20090017517A1
公开(公告)日：2009-01-15
申请号：US12171842
申请日：2008-07-11
申请人： Jeanne Schickli , Jasmine Kaur , Roderick Tang
发明人： Jeanne Schickli , Jasmine Kaur , Roderick Tang
IPC分类号： C12N13/00
CPC分类号： C12N7/00 , C12N2760/18361 , C12N2760/18561
摘要： The present invention encompasses methods of preparing non-segmented negative-stranded RNA viruses from cells utilizing electroporation.
摘要翻译： 本发明包括使用电穿孔从细胞制备非分段负链RNA病毒的方法。
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公开(公告)号：US07465574B2
公开(公告)日：2008-12-16
申请号：US11078900
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译： 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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公开(公告)号：US20080279892A1
公开(公告)日：2008-11-13
申请号：US11690957
申请日：2007-03-26
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20050158340A1
公开(公告)日：2005-07-21
申请号：US11079002
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Clarke , Peter Palese
IPC分类号： A61K39/00 , C07K14/11 , C07K14/135 , C12N7/04 , C12N15/86 , C12Q1/70 , C07H21/02 , C12N7/00 , C12Q1/68
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译： 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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8.发明申请Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus 审中-公开重组副流感病毒表达系统和包含源自偏肺病毒的异源抗原的疫苗公开(公告)号：US20050142148A1
公开(公告)日：2005-06-30
申请号：US10831781
申请日：2004-04-23
申请人： Ronaldus Fouchier , Bernadetta Van Den Hoogen , Albertus Dominicus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
发明人： Ronaldus Fouchier , Bernadetta Van Den Hoogen , Albertus Dominicus Erasmus Osterhaus , Aurelia Haller , Roderick Tang
IPC分类号： A61K20060101 , A61K39/12 , A61K39/155 , C07K14/115 , C07K14/135 , C12N7/00 , C12N15/44 , C12N15/86
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , A61K2039/70 , C12N15/86 , C12N2760/18322 , C12N2760/18334 , C12N2760/18534 , C12N2760/18622 , C12N2760/18634 , C12N2760/18643 , C12N2840/203
摘要： The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.
摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（bPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。
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公开(公告)号：US20050084947A1
公开(公告)日：2005-04-21
申请号：US10975060
申请日：2004-10-25
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/00 , A61K39/155 , A61P31/14 , C07K14/11 , C07K14/135 , C12N7/01 , C12N7/04 , C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20090274727A1
公开(公告)日：2009-11-05
申请号：US12435024
申请日：2009-05-04
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/155 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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