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公开(公告)号：US20050164175A1
公开(公告)日：2005-07-28
申请号：US11078900
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/00 , C07K14/11 , C07K14/135 , C12N7/01 , C12N7/04 , C12N15/86 , C12Q1/70 , C07H21/02 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
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公开(公告)号：US20090274727A1
公开(公告)日：2009-11-05
申请号：US12435024
申请日：2009-05-04
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/155 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20090175899A1
公开(公告)日：2009-07-09
申请号：US12267231
申请日：2008-11-07
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译： 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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公开(公告)号：US07205013B2
公开(公告)日：2007-04-17
申请号：US10975060
申请日：2004-10-25
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US06830748B1
公开(公告)日：2004-12-14
申请号：US09368076
申请日：1999-08-03
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： C12N700
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20120308602A1
公开(公告)日：2012-12-06
申请号：US13488700
申请日：2012-06-05
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC分类号： A61K39/155 , A61P31/14 , C12N7/04 , A61P37/04
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20100028377A1
公开(公告)日：2010-02-04
申请号：US12434781
申请日：2009-05-04
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC分类号： A61K39/155 , C12N7/00 , C12N15/11 , A61K35/76
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20050084947A1
公开(公告)日：2005-04-21
申请号：US10975060
申请日：2004-10-25
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
IPC分类号： A61K39/00 , A61K39/155 , A61P31/14 , C07K14/11 , C07K14/135 , C12N7/01 , C12N7/04 , C12N15/86
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US07465574B2
公开(公告)日：2008-12-16
申请号：US11078900
申请日：2005-03-11
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/16122 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
摘要翻译： 本发明涉及遗传工程重组RS病毒和含有用作疫苗的异源基因的病毒载体。 根据本发明，重组RS病毒载体和病毒被工程化以包含异源基因，包括其他病毒，病原体，细胞基因，肿瘤抗原的基因，或编码来自不同RSV病毒株的基因的组合。
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公开(公告)号：US20080279892A1
公开(公告)日：2008-11-13
申请号：US11690957
申请日：2007-03-26
申请人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
发明人： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译： 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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