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公开(公告)号：US11002752B2
公开(公告)日：2021-05-11
申请号：US16361766
申请日：2019-03-22
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.
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公开(公告)号：US10995357B2
公开(公告)日：2021-05-04
申请号：US15866060
申请日：2018-01-09
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , Moshe Ben-David , Mushki Fridman , Yael Gluckman , Dina Gohman , Orly Hammer Munz , Anita Shinderman , Eran Zahavy
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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公开(公告)号：US10188967B2
公开(公告)日：2019-01-29
申请号：US14560273
申请日：2014-12-04
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , Scott Castanon
IPC: C12Q1/24 , B01D29/00 , B01D37/00 , G01N1/40 , G01G17/06 , G01N33/493 , B01L3/00 , G01N5/02 , G01N15/00 , G01F15/12
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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公开(公告)号：US10073036B2
公开(公告)日：2018-09-11
申请号：US15341418
申请日：2016-11-02
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
CPC classification number: G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US20170146515A1
公开(公告)日：2017-05-25
申请号：US15425253
申请日：2017-02-06
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
IPC: G01N33/493 , C12Q1/04 , G01N35/04 , G01N21/03 , G01N35/02
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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Patent Agency Ranking
公开(公告)号：US09506866B2
公开(公告)日：2016-11-29
申请号：US13960387
申请日：2013-08-06
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico , Thomas A. Klausing
CPC classification number: G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US20210238647A1
公开(公告)日：2021-08-05
申请号：US17234066
申请日：2021-04-19
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , Moshe Ben-David , Mushki Fridman , Yael Gluckman , Dina Gohman , Orly Hammer Munz , Anita Shinderman , Eran Zahavy
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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公开(公告)号：US10801962B2
公开(公告)日：2020-10-13
申请号：US16057948
申请日：2018-08-08
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US20180348135A1
公开(公告)日：2018-12-06
申请号：US16057948
申请日：2018-08-08
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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公开(公告)号：US10082452B2
公开(公告)日：2018-09-25
申请号：US14172491
申请日：2014-02-04
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.
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