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公开(公告)号：US09606105B2
公开(公告)日：2017-03-28
申请号：US14330450
申请日：2014-07-14
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico , John S. Laudo
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US20170146515A1
公开(公告)日：2017-05-25
申请号：US15425253
申请日：2017-02-06
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
IPC: G01N33/493 , C12Q1/04 , G01N35/04 , G01N21/03 , G01N35/02
CPC classification number: G01N33/493 , C12Q1/04 , G01N21/0303 , G01N35/025 , G01N35/04 , G01N2021/6482 , G01N2035/0436 , G01N2035/0444 , G01N2035/0448 , G01N2035/0458 , G01N2201/0415
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US10905978B2
公开(公告)日：2021-02-02
申请号：US16161685
申请日：2018-10-16
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: B01D29/00 , G01N1/30 , B01D37/00 , G01N1/40 , G01N1/28 , G01G17/06 , B01L3/00 , G01N33/493 , C12Q1/24 , G01N5/02 , G01N15/00 , G01F15/12
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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4.发明申请公开(公告)号：US20190046902A1
公开(公告)日：2019-02-14
申请号：US16161685
申请日：2018-10-16
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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5.发明申请公开(公告)号：US20150151253A1
公开(公告)日：2015-06-04
申请号：US14560363
申请日：2014-12-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
CPC classification number: B01D29/0095 , B01D37/00 , B01L3/502753 , B01L2300/0681 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , C12Q1/24 , G01F15/125 , G01G17/06 , G01N1/2813 , G01N1/30 , G01N1/4077 , G01N5/02 , G01N33/493 , G01N2001/4088 , G01N2015/0053 , Y10T436/25375
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 还可以使用使用滑阀的构造。 此外，供应和接收容器的布置可以用于最小化所需容器的数量。 可以结合质量流量计来测量洗脱流体的流动。 最后，过滤过程的洗涤阶段可用于在颗粒上引入污染物用于进一步分析，例如与革兰氏染色相关的染色，并且可以进一步分析这些染色的颗粒。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20210187417A1
公开(公告)日：2021-06-24
申请号：US17141322
申请日：2021-01-05
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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公开(公告)号：US20200240977A1
公开(公告)日：2020-07-30
申请号：US16842061
申请日：2020-04-07
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
IPC: G01N33/493 , C12Q1/04 , G01N21/03 , G01N35/02 , G01N35/04
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US10656140B2
公开(公告)日：2020-05-19
申请号：US15425253
申请日：2017-02-06
Applicant: POCARED Diagnostics LTD.
Inventor： Gal Ingber , William G. Atterbury , Russell H. Barnes , Douglas E. Boyd , Joseph D. Dennis , Jonathan Gurfinkel , Dave Holley , Steven E. Huckaby , Thomas A. Klausing , John S. Laudo , Kevin Sadeski , Jason A. Schaefer , K. Bryan Scott , Carol Stillman , Sherwood Talbert , John Tallarico
Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.
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公开(公告)号：US10130902B2
公开(公告)日：2018-11-20
申请号：US14560363
申请日：2014-12-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: B01D29/00 , B01D37/00 , B01L3/00 , C12Q1/24 , G01N1/40 , G01G17/06 , G01N33/493 , G01N33/49 , G01N5/02 , G01N15/00 , G01F15/12
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
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公开(公告)号：US10018564B2
公开(公告)日：2018-07-10
申请号：US15060703
申请日：2016-03-04
Applicant: POCARED Diagnostics LTD.
Inventor： Jonathan Gurfinkel , Gal Ingber
IPC: G01N21/64 , C12Q1/04 , G01N33/483
CPC classification number: G01N21/6486 , C12Q1/04 , G01N33/4833 , G01N2021/6417 , G01N2201/062 , G01N2201/129
Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.
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