-
公开(公告)号：US11241475B2
公开(公告)日：2022-02-08
申请号：US16306419
申请日：2017-06-27
发明人： Chihiro Suzuki , Utano Nakamura , Mujo Kim
IPC分类号： A61K38/07 , A61K38/04 , C07K5/00 , C07K5/04 , C07K5/10 , A61P19/08 , A61P19/02 , A61K38/08 , A61K9/00
摘要： Provided is an agent for preventing and/or treating osteogenesis imperfecta, osteoporosis and/or osteoarthritis, the agent comprising a peptide consisting of one of the following amino acid sequences: (a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu (SEQ ID NO: 1) and (b) Val-Asn-Pro-Glu (SEQ ID NO: 2). The agent of the present invention can be orally ingested, has osteogenic function, and has a preventive and/or healing-promoting effect on bone fractures and is therefore very useful for prevention and/or treatment of osteogenesis imperfecta, osteoporosis and/or osteoarthritis.
-
公开(公告)号：US20180044434A1
公开(公告)日：2018-02-15
申请号：US15555808
申请日：2016-03-07
申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY , PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , PHARMA FOODS INTERNATIONAL CO., LTD.
发明人： Mamoru SATO , Michiyuki YAMADA , Satoshi KANAZAWA , Masayoshi TOYOURA , Yuji SHOYA , Kenji SAITO , Chihiro YAMAZAKI
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N9/99 , C12N15/09 , C12Y305/03015 , A61K2300/00
摘要： Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0×10−9 or less. Optionally, the anti-PAD4 antibody and a TNFα inhibitor are used in combination.
-
公开(公告)号：US20180021429A1
公开(公告)日：2018-01-25
申请号：US15550461
申请日：2016-02-16
发明人： Chie KUDO , Masayoshi TOYOURA , Akiko ISHIDA , Yuji SHOYA , Chihiro YAMAZAKI
IPC分类号： A61K39/395 , C07K16/18
摘要： The present invention provides an anti-FSTL1 antibody or a fragment or functional equivalent thereof, wherein the antibody recognizes an epitope in a region selected from the group consisting of amino acid positions 48 to 100, 148 to 162, 193 to 216, 205 to 228, and 272 to 289 of SEQ ID NO: 1 (amino acid sequence of human FSTL1). The present invention also provides a combination product of a FSTL1 suppressor and additional cancer treatment. It is understood that immune defect such as immunosuppression or immunodeficiency is effectively mitigated by the present invention.
-
4.发明申请公开(公告)号：US20160362466A1
公开(公告)日：2016-12-15
申请号：US15121471
申请日：2015-02-25
发明人： Chihiro YAMAZAKI , Ji-Yeong AN , Seiyu HARADA , Kazuya WATABE , Mujo KIM
摘要： The present invention provides a novel peptide having bone formation-promoting effect and chondrocyte growth-promoting effect, in particular, a peptide having osteoblast growth-promoting activity, having 100 amino acid residues or less comprising an amino acid sequence selected from(a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu (SEQ ID NO: 1), (b) an amino acid sequence derived from the amino acid sequence (a) by conservative substitution or deletion of 1 to 3 amino acids, and (c) an amino acid sequence consisting of at least four contiguous amino acids of the amino acid sequence (a) or (b), or a derivative thereof or a salt thereof.
-
5.发明申请公开(公告)号：US20230126610A1
公开(公告)日：2023-04-27
申请号：US17910580
申请日：2021-03-08
发明人： Atsushi YAMATSU , Utano NAKAMURA , Tomoko SAKATA , Mujo KIM , Yasuhiro YOKOYAMA
IPC分类号： A61K31/197 , A23L33/175 , A61P25/28
摘要： Provided is a novel composition for preventing the deterioration in a cognitive function or improving the cognitive function in a subject. A composition for preventing the deterioration in a cognitive function and/or improving the cognitive function in a subject, the composition containing γ-aminobutyric acid.
-
公开(公告)号：US10806787B2
公开(公告)日：2020-10-20
申请号：US15550461
申请日：2016-02-16
发明人： Chie Kudo , Masayoshi Toyoura , Akiko Ishida , Yuji Shoya , Chihiro Yamazaki
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61K45/06 , A61K31/675 , C12N15/09 , A61K39/00
摘要： The present invention provides an anti-FSTL1 antibody or a fragment or functional equivalent thereof, wherein the antibody recognizes an epitope in a region selected from the group consisting of amino acid positions 48 to 100, 148 to 162, 193 to 216, 205 to 228, and 272 to 289 of SEQ ID NO: 1 (amino acid sequence of human FSTL1). The present invention also provides a combination product of a FSTL1 suppressor and additional cancer treatment. It is understood that immune defect such as immunosuppression or immunodeficiency is effectively mitigated by the present invention.
-
公开(公告)号：US10154684B2
公开(公告)日：2018-12-18
申请号：US15522231
申请日：2015-10-30
发明人： Seiyu Harada , Toshio Nakamura , Mujo Kim
摘要： The present invention provides a hair regrowth promoter comprising an egg-yolk protein hydrolysate as an active ingredient. The egg-yolk protein hydrolysate is a safe ingredient produced from a natural source, and therefore can be widely used in daily consumable products, such as food and drink products, medicaments, animal feeds, and dietary supplements, or as a food additive, etc. The promoter etc. of the present invention can be orally administered and is thus very advantageous.
-
公开(公告)号：US20180036350A1
公开(公告)日：2018-02-08
申请号：US15670918
申请日：2017-08-07
发明人： Isafumi Maru , Ji-Yeong An , Sayuri Tanaka , Maya Sakashita , Seiyu Harada , Kazuya Watabe , Masayoshi Aosasa , Mujo Kim , Toshio Nakamura , Utano Nakamura , Hiroaki Iitsuka
IPC分类号： A61K35/57 , A61K38/05 , A61K8/98 , A61K8/64 , A23L33/00 , A61Q19/00 , A61Q19/08 , A23L2/52 , A23C9/123 , A23C19/00 , A61K31/7004 , A61K8/60
CPC分类号： A61K35/57 , A23C9/123 , A23C9/1322 , A23C19/00 , A23C19/093 , A23L2/52 , A23L2/56 , A23L2/60 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K8/60 , A61K8/64 , A61K8/65 , A61K8/735 , A61K8/981 , A61K9/2068 , A61K9/4875 , A61K31/7004 , A61K38/012 , A61K38/014 , A61K38/05 , A61Q19/007 , A61Q19/08 , A23V2250/542
摘要： An agent of the present invention comprising poultry feet or a processed product thereof, preferably a hydrolysate of an extract of poultry feet, promotes hyaluronic acid production, thereby exhibiting excellent effects of preventing or treating a joint disorder, improving skin dryness, wrinkles or skin tension, moisturizing the skin, etc. The agent is thus useful as a medicament, a quasi-drug, a cosmetic product, a food product or an animal feed.
-
公开(公告)号：US20240309112A1
公开(公告)日：2024-09-19
申请号：US18546981
申请日：2022-02-18
发明人： Yuya MIYAMOTO , Koichi WADA , Yuichi IMURA , Kenji SAITO , Tomoko SAKATA , Takanari SHIGEMITSU
CPC分类号： C07K16/40 , A61P19/02 , A61P37/06 , A61K2039/505 , C07K2317/565 , C07K2317/92
摘要： Provided is an anti-PAD4 antibody or an antibody fragment thereof, wherein HCDR1 comprises an amino acid sequence of SEQ ID NO: 1, HCDR2 comprises an amino acid sequence of SEQ ID NO: 2, HCDR3 comprises an amino acid sequence of SEQ ID NO: 3, LCDR1 comprises an amino acid sequence of SEQ ID NO: 4, LCDR2 comprises an amino acid sequence of SEQ TD NO: 5, and LCDR3 comprises an amino acid sequence of SEQ ID NO: 6.
-
10.发明授权公开(公告)号：US11844762B2
公开(公告)日：2023-12-19
申请号：US17183646
申请日：2021-02-24
发明人： Hiroaki Iitsuka , Sayo Morita , Keita Koga , Atsushi Yamatsu , Mujo Kim , Toma Furuta
IPC分类号： A61K36/185 , A61P3/04 , A23L33/00 , A23L25/00 , A23K10/30 , A23L33/105
CPC分类号： A61K36/185 , A23K10/30 , A23L25/30 , A23L33/105 , A23L33/40 , A61P3/04 , A23V2002/00
摘要： Problem to be solved: An object of the present invention is to provide a novel fat absorption inhibiting agent.
Solution to the problem: The present invention provides a fat absorption inhibiting agent comprising pulverized defatted sesame seeds or a processed product thereof. The present invention also provides a fat absorption inhibiting agent comprising defatted sesame seeds having a 50th percentile particle size of 1 to 200 μm as determined by laser diffraction/scattering and a compressibility index of 30 to 80%. The fat absorption inhibiting agent of the present invention preferably has lipase inhibitory activity. The present invention also provides a food comprising the agent. The present invention also provides defatted sesame seeds having a 50th percentile particle size of 1 to 200 μm as determined by laser diffraction/scattering and a compressibility index of 30 to 80%. The present invention provides a method for inhibiting obesity in a human or animal, the method comprising administering to a human or animal the agent, the food or the defatted sesame seeds.
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.019 秒)
