专利检索 ap:("PHARMA FOODS INTERNATIONAL CO., LTD.") AND inv:"Akiko Ishida" 第 1 页

1.

发明授权
Anticancer agents or antimetastatic agents using FSTL1 and combination drug thereof 有权

公开(公告)号：US10806787B2

公开(公告)日：2020-10-20

申请号：US15550461

申请日：2016-02-16

申请人： PHARMA FOODS INTERNATIONAL CO., LTD.

发明人： Chie Kudo , Masayoshi Toyoura , Akiko Ishida , Yuji Shoya , Chihiro Yamazaki

IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61K45/06 , A61K31/675 , C12N15/09 , A61K39/00

摘要： The present invention provides an anti-FSTL1 antibody or a fragment or functional equivalent thereof, wherein the antibody recognizes an epitope in a region selected from the group consisting of amino acid positions 48 to 100, 148 to 162, 193 to 216, 205 to 228, and 272 to 289 of SEQ ID NO: 1 (amino acid sequence of human FSTL1). The present invention also provides a combination product of a FSTL1 suppressor and additional cancer treatment. It is understood that immune defect such as immunosuppression or immunodeficiency is effectively mitigated by the present invention.