公开(公告)号：US20070032433A1

公开(公告)日：2007-02-08

申请号：US10052386

申请日：2002-01-18

申请人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping Mc Cormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Tin-Yau Chan ,  Yi-Tsung Liu ,  Zhaoning Zhu ,  F. Njoroge ,  Ashok Arasappan ,  Tejal Parekh ,  Ashit Ganguly ,  Kevin Chen ,  Srikanth Venkatraman ,  Henry Vaccaro ,  Patrick Pinto ,  Bama Santhanam ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-wilby ,  Susan Tamura ,  Wanli Wu ,  Siska Hendrata ,  Yuhua Huang ,  Jesse Wong ,  Latha Nair

发明人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping Mc Cormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Tin-Yau Chan ,  Yi-Tsung Liu ,  Zhaoning Zhu ,  F. Njoroge ,  Ashok Arasappan ,  Tejal Parekh ,  Ashit Ganguly ,  Kevin Chen ,  Srikanth Venkatraman ,  Henry Vaccaro ,  Patrick Pinto ,  Bama Santhanam ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-wilby ,  Susan Tamura ,  Wanli Wu ,  Siska Hendrata ,  Yuhua Huang ,  Jesse Wong ,  Latha Nair

IPC分类号： A61K38/06 ,  A61K38/04 ,  C07K17/00 ,  C07K16/00 ,  C07K7/00 ,  C07K5/00 ,  A61K38/00

CPC分类号： C07K5/0804 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0812 ,  C07K5/0827 ,  C07K7/02

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

公开(公告)号：US20050176648A1

公开(公告)日：2005-08-11

申请号：US11089192

申请日：2005-03-24

申请人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Stephane Bogen ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Yi-Tsung Liu ,  Tin-Yau Chan ,  Zhaoning Zhu ,  Ashok Arasappan ,  Kevin Chen ,  Srikanth Venkatraman ,  Tejal Parekh ,  Patrick Pinto ,  Bama Santhanam ,  F. Njoroge ,  Ashit Ganguly ,  Henry Vaccaro ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby ,  Susan Tamura

发明人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Stephane Bogen ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Yi-Tsung Liu ,  Tin-Yau Chan ,  Zhaoning Zhu ,  Ashok Arasappan ,  Kevin Chen ,  Srikanth Venkatraman ,  Tejal Parekh ,  Patrick Pinto ,  Bama Santhanam ,  F. Njoroge ,  Ashit Ganguly ,  Henry Vaccaro ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby ,  Susan Tamura

IPC分类号： C12N9/99 ,  A61K31/16 ,  A61K31/195 ,  A61K31/27 ,  A61K31/357 ,  A61K31/385 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/445 ,  A61K31/7052 ,  A61K38/00 ,  A61K38/05 ,  A61K38/21 ,  A61K38/55 ,  A61K45/00 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P43/00 ,  C07C205/51 ,  C07C229/00 ,  C07D209/02 ,  C07K5/02 ,  C07K5/103 ,  C07K7/02 ,  C07K7/04 ,  C07K7/06 ,  A61K38/06 ,  A61K31/165 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K31/16 ,  A61K31/195 ,  A61K31/27 ,  A61K31/357 ,  A61K31/385 ,  A61K31/403 ,  A61K31/4164 ,  A61K31/445 ,  A61K38/05 ,  C07C205/51 ,  C07K5/101 ,  C07K7/02 ,  A61K2300/00

摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

公开(公告)号：US09937025B2

公开(公告)日：2018-04-10

申请号：US15089433

申请日：2016-04-01

申请人： Adolf Patrick Pinto

发明人： Adolf Patrick Pinto

IPC分类号： A61C15/04 ,  A61B5/00

CPC分类号： A61C15/042 ,  A61B5/0053 ,  A61B5/4547 ,  A61B5/4827 ,  A61B5/4836 ,  A61C15/04 ,  A61C15/046

摘要： This disclosure proposes a technique for finding and treating areas of tooth decay primarily below the gum line using protuberances provided in a length of modified dental floss. The length of modified dental floss is provided with protuberances which can be used to detect areas of tooth decay by the roughness and sensitivity felt as the length of modified dental floss glides over the area of tooth decay. Specially designed posts are used to anchor the ends of the length of modified dental floss in order to be able to apply greater force during flossing, and free up fingers that would normally have the dental floss wrapped around them, to guide the floss to the right locations for flossing.

公开(公告)号：US08671676B2

公开(公告)日：2014-03-18

申请号：US12884387

申请日：2010-09-17

申请人： Adolf Patrick Pinto

发明人： Adolf Patrick Pinto

IPC分类号： F02G1/043

CPC分类号： F02G1/043 ,  F02G2242/00

摘要： This disclosure provides a method for efficiently converting heat energy to readily usable energy with maximized thermal efficiency. Maximized thermal efficiency is obtained by the use of heat regeneration and working gas processing steps that optimize the heat regeneration, so that any heat that is supplied to the working gas from the external heat source is supplied at the maximum temperature, and any heat that is rejected from the working gas to an external heat sinks is rejected at the minimum temperature, given the constraints of the the heat source and heat sink temperatures. Two basic designs of engines are proposed. One of the basic designs uses pairs of heat regenerators, and would be suitable for stationary power generation applications. The other basic design uses single heat regenerators and would be suited for motive power applications. Both piston cylinder and turbocompressor driven engine applications can be used in each of the two basic designs of engines.

摘要翻译： 本公开提供了一种用于以最大的热效率将热能有效地转化为易于使用的能量的方法。 通过使用优化热再生的热再生和工作气体处理步骤获得最大化的热效率，从而在最高温度下供给来自外部热源的供给工作气体的任何热量， 考虑到热源和散热器温度的限制，从工作气体排除到外部散热片的最低温度被拒绝。 提出了两种基本的发动机设计。 其中一个基本设计使用了一对热交换器，适用于固定式发电应用。 另一个基本设计使用单个热交换器，并且适用于动力应用。 活塞气缸和涡轮压缩机驱动的发动机应用都可以用于发动机的两个基本设计中的每一个。

公开(公告)号：US20170281322A1

公开(公告)日：2017-10-05

申请号：US15089433

申请日：2016-04-01

申请人： Adolf Patrick Pinto

发明人： Adolf Patrick Pinto

IPC分类号： A61C15/04 ,  A61B5/00

CPC分类号： A61C15/042 ,  A61B5/0053 ,  A61B5/4547 ,  A61B5/4827 ,  A61B5/4836 ,  A61C15/04 ,  A61C15/046

摘要： This disclosure proposes a technique for finding and treating areas of tooth decay primarily below the gum line using protuberances provided in a length of modified dental floss. The length of modified dental floss is provided with protuberances which can be used to detect areas of tooth decay by the roughness and sensitivity felt as the length of modified dental floss glides over the area of tooth decay. Specially designed posts are used to anchor the ends of the length of modified dental floss in order to be able to apply greater force during flossing, and free up fingers that would normally have the dental floss wrapped around them, to guide the floss to the right locations for flossing.

公开(公告)号：US20140057836A1

公开(公告)日：2014-02-27

申请号：US13960343

申请日：2013-08-06

申请人： Thomas BARA ,  Sathesh Bhat ,  Dipshika Biswas ,  Linda Brockunier ,  Duane Burnette ,  Samuel Chackalamannil ,  Mariappan Vasu Cheliah ,  Austin Chen ,  Martin Clasby ,  Vince J. Colandrea ,  Zhuyan Guo ,  Yongxin Han ,  Charles Jayne ,  Hubert Josien ,  Karen Marcantonio ,  Shouwu Miao ,  Santhosh Neelamkavil ,  Patrick Pinto ,  Murali Rajogopalan ,  Unmesh Shah ,  Francisco Velazquez ,  Srikanth Venkatraman ,  Yan Xia

发明人： Thomas BARA ,  Sathesh Bhat ,  Dipshika Biswas ,  Linda Brockunier ,  Duane Burnette ,  Samuel Chackalamannil ,  Mariappan Vasu Cheliah ,  Austin Chen ,  Martin Clasby ,  Vince J. Colandrea ,  Zhuyan Guo ,  Yongxin Han ,  Charles Jayne ,  Hubert Josien ,  Karen Marcantonio ,  Shouwu Miao ,  Santhosh Neelamkavil ,  Patrick Pinto ,  Murali Rajogopalan ,  Unmesh Shah ,  Francisco Velazquez ,  Srikanth Venkatraman ,  Yan Xia

IPC分类号： C07K5/08 ,  A61K45/06 ,  A61K38/06

CPC分类号： C07K5/08 ,  A61K38/06 ,  A61K45/06 ,  C07D419/00 ,  C07D491/22

摘要： The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

摘要翻译： 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途，以及这些化合物的合成。

公开(公告)号：US20060205672A1

公开(公告)日：2006-09-14

申请号：US11241656

申请日：2005-09-30

申请人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Tin-Yau Chan ,  Yi-Tsung Liu ,  Zhaoning Zhu ,  F. Njoroge ,  Ashok Arasappan ,  Tejal Parekh ,  Ashit Ganguly ,  Kevin Chen ,  Srikanth Venkatraman ,  Henry Vaccaro ,  Patrick Pinto ,  Bama Santhanam ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby ,  Susan Tamura ,  Wanli Wu ,  Siska Hendrata ,  Yuhua Huang

发明人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Tin-Yau Chan ,  Yi-Tsung Liu ,  Zhaoning Zhu ,  F. Njoroge ,  Ashok Arasappan ,  Tejal Parekh ,  Ashit Ganguly ,  Kevin Chen ,  Srikanth Venkatraman ,  Henry Vaccaro ,  Patrick Pinto ,  Bama Santhanam ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby ,  Susan Tamura ,  Wanli Wu ,  Siska Hendrata ,  Yuhua Huang

IPC分类号： A61K38/05 ,  C07K5/06

CPC分类号： C07K5/0202 ,  A61K38/00 ,  C07K5/0812 ,  C07K5/0827 ,  C07K7/02

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：US20050119168A1

公开(公告)日：2005-06-02

申请号：US10948367

申请日：2004-09-23

申请人： Srikanth Venkatraman ,  F. Njoroge ,  Wanli Wu ,  Viyyoor Girijavallabhan ,  Brian McKittrick ,  Jing Su ,  Francisco Velazquez ,  Patrick Pinto

发明人： Srikanth Venkatraman ,  F. Njoroge ,  Wanli Wu ,  Viyyoor Girijavallabhan ,  Brian McKittrick ,  Jing Su ,  Francisco Velazquez ,  Patrick Pinto

IPC分类号： A61K31/33 ,  A61K38/00 ,  A61K38/12 ,  A61K38/21 ,  C07D245/04 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D487/04 ,  C07D513/04 ,  C07K5/02 ,  C07K5/08

CPC分类号： C07D245/04 ,  A61K31/33 ,  A61K38/12 ,  A61K38/21 ,  A61K38/212 ,  C04B35/632 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D487/04 ,  C07D513/04 ,  C07K5/0217 ,  C07K5/0802 ,  A61K2300/00

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula 1: wherein Z′, L′, M′, R1, X and D are defined herein.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新化合物以及包含这些化合物的药物组合物及其用于治疗与HCV蛋白酶相关的病症的方法。 新化合物通常包括15-20个成员大环，并且具有结构式1的一般结构：其中Z'，L'，M'，R 1，X和D在本文中定义。

公开(公告)号：US20050059606A1

公开(公告)日：2005-03-17

申请号：US10934141

申请日：2004-09-03

申请人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Ashok Arasappan ,  Tejal Parekh ,  Patrick Pinto ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Yi-Tsung Liu ,  F. Njoroge ,  Ashit Ganguly ,  Terence Brunck ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby

发明人： Anil Saksena ,  Viyyoor Girijavallabhan ,  Raymond Lovey ,  Edwin Jao ,  Ashok Arasappan ,  Tejal Parekh ,  Patrick Pinto ,  Frank Bennett ,  Jinping McCormick ,  Haiyan Wang ,  Russell Pike ,  Stephane Bogen ,  Yi-Tsung Liu ,  F. Njoroge ,  Ashit Ganguly ,  Terence Brunck ,  Scott Kemp ,  Odile Levy ,  Marguerita Lim-Wilby

IPC分类号： C12N9/99 ,  A61K31/7052 ,  A61K38/00 ,  A61K38/21 ,  A61K38/55 ,  A61K45/00 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  A61P35/00 ,  A61P43/00 ,  C07K7/00 ,  C07K7/02 ,  C07K7/06 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/02

摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些肽的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。