公开(公告)号：US09988405B2

公开(公告)日：2018-06-05

申请号：US15596096

申请日：2017-05-16

申请人： Neopanora Bio-technology (Zhuhai) Ltd.

发明人： Xianzhang Bu ,  Cuige Zhu ,  Xin Yue ,  Yinglin Zuo ,  Yu Chen ,  Gesi Wen

IPC分类号： C07C255/22 ,  C07C49/255 ,  C07C49/248 ,  C07C255/56 ,  C07C65/38 ,  C07C309/44 ,  C07D295/112 ,  C07F9/12 ,  C07F5/02 ,  C07C225/22

CPC分类号： C07F9/12 ,  C07C45/45 ,  C07C45/63 ,  C07C49/248 ,  C07C49/255 ,  C07C49/835 ,  C07C49/84 ,  C07C51/347 ,  C07C51/373 ,  C07C65/38 ,  C07C221/00 ,  C07C225/22 ,  C07C253/30 ,  C07C255/56 ,  C07C303/22 ,  C07C309/44 ,  C07D207/08 ,  C07D295/112 ,  C07D295/12 ,  C07F5/025 ,  C07C49/813

摘要： Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and has a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.