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公开(公告)号：US20250041326A1
公开(公告)日：2025-02-06
申请号：US18708460
申请日：2022-11-09
Applicant: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE , NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
Inventor： Michinori KOHARA , Naoki YAMAMOTO , Yasuhito TANAKA , Yusuke SATO
IPC: A61K31/713 , A61K31/522 , A61K38/17 , A61K38/21 , A61K47/54 , A61K47/69 , A61P31/20
Abstract: The present invention provides a therapeutic agent for refractory viral infections, etc., which is capable of reducing or eliminating cccDNA from hepatocytes. The therapeutic agent for refractory viral infections according to the present invention is characterized by comprising a complex encapsulating poly-I or a poly-I analog and poly-C or a poly-C analog within a drug carrier useful for drug delivery into cells, wherein the surface of the carrier is conjugated with a molecule imparting the ability to accumulate in hepatocytes.
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公开(公告)号：US12150939B2
公开(公告)日：2024-11-26
申请号：US17106565
申请日：2020-11-30
Inventor： Takumi Era , Takayuki Kiboku
IPC: A61K31/443 , A61P19/08
Abstract: A pathological mechanism in FOP patients is further revealed, and development of a novel therapeutic drug, therapeutic method, diagnostic method, etc. utilizing an obtained finding is provided. The inventors have found a novel finding that in FOP, ectopic ossification, which occurs by an inflammation due to an injury, etc., is mediated by PAR1 to occur. From this finding, the inventors completed the present invention relating to a drug, etc. characterized by suppressing ectopic ossification in FOP by inhibiting PAR1.
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3.发明公开公开(公告)号：US20240228306A9
公开(公告)日：2024-07-11
申请号：US18278769
申请日：2022-02-22
Inventor： Shintaro IDA , Keisuke AWAYA , Kazutoshi SEKIGUCHI , Hirotake KITAGAWA , Shuhei YAMADA
IPC: C01B33/32 , H01M8/1016
CPC classification number: C01B33/325 , H01M8/1016 , C01P2004/03 , C01P2004/20 , C01P2006/40
Abstract: A dispersion of exfoliated particles which includes at least one nitrogen-containing basic compound (A) which is a tertiary amine or a quaternary ammonium hydroxide having at least one alkyl group having 3 or 4 carbon atoms, and in which exfoliated particles (C) produced by interlayer-exfoliating a proton-type layered polysilicate compound (B) are dispersed in an aqueous solution (D) having 10 vol % to 90 vol % of an alcohol having 1 to 3 carbon atoms; and a film-forming composition, a porous body-forming composition, an LB film, a coating film, a free-standing membrane, a proton conductor, an electrolyte membrane for fuel cells, and a porous body each containing exfoliated particles.
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4.发明公开公开(公告)号：US20240132365A1
公开(公告)日：2024-04-25
申请号：US18278769
申请日：2022-02-22
Inventor： Shintaro IDA , Keisuke AWAYA , Kazutoshi SEKIGUCHI , Hirotake KITAGAWA , Shuhei YAMADA
IPC: C01B33/32 , H01M8/1016
CPC classification number: C01B33/325 , H01M8/1016 , C01P2004/03 , C01P2004/20 , C01P2006/40
Abstract: A dispersion of exfoliated particles which includes at least one nitrogen-containing basic compound (A) which is a tertiary amine or a quaternary ammonium hydroxide having at least one alkyl group having 3 or 4 carbon atoms, and in which exfoliated particles (C) produced by interlayer-exfoliating a proton-type layered polysilicate compound (B) are dispersed in an aqueous solution (D) having 10 vol % to 90 vol % of an alcohol having 1 to 3 carbon atoms; and a film-forming composition, a porous body-forming composition, an LB film, a coating film, a free-standing membrane, a proton conductor, an electrolyte membrane for fuel cells, and a porous body each containing exfoliated particles.
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公开(公告)号：US20220031838A1
公开(公告)日：2022-02-03
申请号：US17279850
申请日：2019-09-26
Inventor： Shogo MISUMI , Naoki KISHIMOTO , Ryotaro MITSUMATA , Nagisa NAKATA , Takuma GOTANDA
IPC: A61K39/39 , A61K39/145 , A61K9/00
Abstract: A mucosal adjuvant may have high mucosal immunogenicity and high safety and be useful in the preparation of mucosal vaccines, and a mucosal vaccine composition may include the same. Such mucosal adjuvant may include TGDK. A method for preparing the mucosal vaccine composition may include mixing TGDK with an immunogen.
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Patent Agency Ranking
公开(公告)号：US11135425B2
公开(公告)日：2021-10-05
申请号：US15768253
申请日：2016-10-13
Inventor： Hirofumi Kai , Tsuyoshi Shuto , Ann Soten Mary Suico , Eiichi Araki , Tatsuya Kondo
Abstract: Provided is a new means for suppressing inflammation or suppressing inflammatory cytokine production. Provided is a device in which a weak pulse current is passed through a living body or living tissue to suppress inflammation in the living body or the living tissue. This device is provided with a power supply means, and a current control means for receiving a supply of power to intermittently apply a direct current at prescribed intervals, and is configured such that the current control means includes a pulse width modulation control means, and the pulse width modulation control means generates a pulse wave that is a rectangular wave, and in which the time indicating a peak value for rising in one cycle of the pulse wave (“pulse duration”) is at least 0.1 millisecond, the peak value is 1.0-20 V, inclusive, and the duty ratio of the pulse wave is at least 5.5%.
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公开(公告)号：US10765094B2
公开(公告)日：2020-09-08
申请号：US15329477
申请日：2014-07-31
Applicant: TRANSGENIC INC. , NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY , NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
Inventor： Kenichi Yamamura , Takao Iwawaki , Daisuke Oikawa , Tomoo Ishikawa
Abstract: The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.
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公开(公告)号：US20200253942A1
公开(公告)日：2020-08-13
申请号：US15776152
申请日：2016-11-17
Inventor： Takumi ERA , Takayuki Kiboku
IPC: A61K31/443 , A61P19/08
Abstract: A pathological mechanism in FOP patients is further revealed, and development of a novel therapeutic drug, therapeutic method, diagnostic method, etc. utilizing an obtained finding is provided. The inventors have found a novel finding that in FOP, ectopic ossification, which occurs by an inflammation due to an injury, etc., is mediated by PAR1 to occur. From this finding, the inventors completed the present invention relating to a drug, etc. characterized by suppressing ectopic ossification in FOP by inhibiting PAR1.
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公开(公告)号：US10138535B2
公开(公告)日：2018-11-27
申请号：US15030229
申请日：2014-10-22
Inventor： Yoshihito Kawamura , Michiaki Yamasaki
Abstract: A magnesium alloy having high strength and high ductility and in which at least one of corrosion resistance and flame resistance is enhanced, or a method of manufacturing the same. The magnesium alloy contains an atomic % of Ca and b atomic % of Al, totally contains k atomic % of at least one element selected from a group consisting of Mn, Zr, Ag, Y and Nd, has a composition in which a remaining part is formed of Mg and contains c volume % of (Mg, Al)2Ca, a, b, c and k satisfying formulae (1) to (4) and (21) below. The (Mg, Al)2Ca is dispersed and the at least one element is an element that enhances at least one of corrosion resistance and flame resistance: (1) 3≤a≤7, (2) 4.5≤b≤12, (3) 1.2≤b/a≤3.0, (4) 10≤c≤35, (21) 0
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公开(公告)号：US20180178192A1
公开(公告)日：2018-06-28
申请号：US15748542
申请日：2016-07-29
Inventor： Masayo SAKATA , Towako SAKAMOTO , Daisuke NAKAMURA , Yuki MAEDA
CPC classification number: B01J20/24 , A61K9/70 , A61K47/38 , B01D15/00 , B01D15/36 , B01D15/363 , B01J20/22 , B01J20/262 , B01J20/265 , B01J20/28004 , B01J20/28007 , B01J20/28023 , B01J20/30 , B01J20/3085 , B01J20/3212 , B01J20/3248 , C02F1/28 , C02F1/42 , C02F2001/422 , C02F2101/34
Abstract: Means for removing endotoxin is provided. Endotoxin is removed by contacting an endotoxin adsorbent including a cellulose nanofiber having an amino group with a liquid containing endotoxin.
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