Process to study changes in gene expression in stem cells
    6.
    发明申请
    Process to study changes in gene expression in stem cells 审中-公开
    研究干细胞基因表达变化的过程

    公开(公告)号:US20070154930A1

    公开(公告)日:2007-07-05

    申请号:US11633033

    申请日:2006-12-04

    CPC classification number: C12Q1/6809

    Abstract: The present invention includes a method to identify stem cell genes that are differentially expressed in stem cells at various stages of differentiation when compared to undifferentiated stem cells by preparing a gene expression profile of a stem cell population and comparing the profile to a profile prepared from stem cells at different stages of differentiation, thereby identifying cDNA species, and therefore genes, which are expressed. The present invention also includes methods to identify a therapeutic agent that modulates the expression of at least one stem cell gene associated with the differentiation, proliferation and/or survival of stem cells.

    Abstract translation: 本发明包括一种通过制备干细胞群体的基因表达谱来鉴定在与未分化干细胞相比较时在不同分化阶段在干细胞中差异表达的干细胞基因的方法,并将其与由茎制备的轮廓比较 细胞处于不同的分化阶段,从而鉴定cDNA表达,因此鉴定出表达的基因。 本发明还包括鉴定调节与干细胞的分化,增殖和/或存活相关的至少一种干细胞基因的表达的治疗剂的方法。

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