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公开(公告)号：US06514746B1
公开(公告)日：2003-02-04
申请号：US09082077
申请日：1998-05-20
Applicant: Bret Benton , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
IPC: C12N120
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial genes which encode the components of a two-component regulatory pair. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
Abstract translation: 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有编码双组分调节对组分的细菌基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。
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公开(公告)号：US20080108793A1
公开(公告)日：2008-05-08
申请号：US11647506
申请日：2006-12-28
Applicant: Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke McGrath , Bryan Beattie , Mandy Dorsey
Inventor： Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke McGrath , Bryan Beattie , Mandy Dorsey
IPC: C07K14/195 , G01N33/569 , C07K16/00
CPC classification number: C07K14/195 , C07K2299/00
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Abstract translation: 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了包含SEQ ID NO：2所示的氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
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3.发明授权Compositions comprising multiple bioactive agents, and methods of using the same 有权包含多种生物活性剂的组合物及其使用方法公开(公告)号：US07879872B2
公开(公告)日：2011-02-01
申请号：US11231298
申请日：2005-09-19
Applicant: Judd M. Berman , Molly B. Schmid , John D. Mendlein , Nachum Kaplan
Inventor： Judd M. Berman , Molly B. Schmid , John D. Mendlein , Nachum Kaplan
IPC: A61K31/554 , A61K31/517 , A61K31/55 , A61K31/4745 , A61K31/496
CPC classification number: A61K45/06 , A61K31/381 , A61K31/4422 , A61K31/4745 , A61K31/496 , A61K31/4965 , A61K31/517 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K2300/00
Abstract: In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.
Abstract translation: 部分地，本发明涉及具有FabI抑制剂和至少一种其它生物活性剂的组合物。 另一方面，本发明涉及具有式I-III化合物和至少一种其它抗菌剂的抗菌组合物。
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4.发明授权Methods of screening for compounds active on staphylococcus aureus target genes 失效筛选对金黄色葡萄球菌靶基因活性的化合物的方法公开(公告)号：US06187541B1
公开(公告)日：2001-02-13
申请号：US09265315
申请日：1999-03-09
Applicant: Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
IPC: C12Q168
CPC classification number: C12Q1/689 , C12Q1/18 , C12Q2600/136 , C12Q2600/156
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
Abstract translation: 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有在体内表达的细菌发病基因或必需基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。
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公开(公告)号：US6037123A
公开(公告)日：2000-03-14
申请号：US714918
申请日：1996-09-13
Applicant: Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
CPC classification number: C12Q1/689 , C12Q1/18 , C12Q2600/136 , C12Q2600/156
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
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Patent Agency Ranking
公开(公告)号：US07601526B2
公开(公告)日：2009-10-13
申请号：US11647506
申请日：2006-12-28
Applicant: Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke , Bryan Beattie , Mandy Dorsey
Inventor： Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke , Bryan Beattie , Mandy Dorsey
CPC classification number: C07K14/195 , C07K2299/00
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Abstract translation: 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了从包含SEQ ID NO：2所示氨基酸序列的土拉氏弗斯兰氏菌得到的纯化蛋白质。本发明还提供了本发明多肽的生物化学和生物物理学特征。
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7.发明授权Methods of screening for compounds active on staphylococcus aureus target genes 失效筛选对金黄色葡萄球菌靶基因活性的化合物的方法公开(公告)号：US06638718B1
公开(公告)日：2003-10-28
申请号：US09527745
申请日：2000-03-17
Applicant: Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
IPC: C12Q168
CPC classification number: C12Q1/689 , C12Q1/18 , C12Q2600/136 , C12Q2600/156
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
Abstract translation: 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有在体内表达的细菌发病基因或必需基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。
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8.发明授权Methods of screening for compounds active on Staphylococcus aureus target genes 失效筛选对金黄色葡萄球菌靶基因活性的化合物的方法公开(公告)号：US06630303B1
公开(公告)日：2003-10-07
申请号：US09528709
申请日：2000-03-17
Applicant: Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
IPC: C12Q168
CPC classification number: C12Q1/689 , C12Q1/18 , C12Q2600/136 , C12Q2600/156
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
Abstract translation: 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有在体内表达的细菌发病基因或必需基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。
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9.发明申请Compositions Comprising Multiple Bioactive Agents, and Methods of Using the Same 审中-公开包含多种生物活性剂的组合物及其使用方法公开(公告)号：US20120010127A1
公开(公告)日：2012-01-12
申请号：US12962899
申请日：2010-12-08
Applicant: JUDD M. BERMAN , MOLLY B. SCHMID , JOHN D. MENDLEIN , NACHUM KAPLAN
Inventor： JUDD M. BERMAN , MOLLY B. SCHMID , JOHN D. MENDLEIN , NACHUM KAPLAN
IPC: A61K38/14 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61P31/04 , A61K31/444 , A61K31/519 , A61K31/545 , A61K31/65 , A61K31/70 , A61K31/551 , A61K31/5377
CPC classification number: A61K45/06 , A61K31/381 , A61K31/4422 , A61K31/4745 , A61K31/496 , A61K31/4965 , A61K31/517 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K2300/00
Abstract: In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other antibacterial agent.
Abstract translation: 部分地，本发明涉及包含FabI抑制剂和至少一种其它生物活性剂的组合物。 另一方面，本发明涉及包含式I-III化合物和至少一种其它抗菌剂的抗菌组合物。
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10.发明授权Methods of screening for compounds active on Staphylococcus aureus target genes 失效筛选对金黄色葡萄球菌靶基因活性的化合物的方法公开(公告)号：US06228588B1
公开(公告)日：2001-05-08
申请号：US09266417
申请日：1999-03-09
Applicant: Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
Inventor： Bret Benton , Ving J. Lee , Francois Malouin , Patrick K. Martin , Molly B. Schmid , Dongxu Sun
IPC: C12Q168
CPC classification number: C12Q1/689 , C12Q1/18 , C12Q2600/136 , C12Q2600/156
Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.
Abstract translation: 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有在体内表达的细菌发病基因或必需基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。
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