-
公开(公告)号：US20080108793A1
公开(公告)日：2008-05-08
申请号：US11647506
申请日：2006-12-28
Applicant: Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke McGrath , Bryan Beattie , Mandy Dorsey
Inventor： Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke McGrath , Bryan Beattie , Mandy Dorsey
IPC: C07K14/195 , G01N33/569 , C07K16/00
CPC classification number: C07K14/195 , C07K2299/00
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Abstract translation: 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了包含SEQ ID NO：2所示的氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。
-
公开(公告)号：US08450307B2
公开(公告)日：2013-05-28
申请号：US11628569
申请日：2005-06-06
Applicant: Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
Inventor： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC: C07D401/12 , C07D405/12 , C07D409/12 , C07D498/04 , A61K31/551 , A61K31/5365
CPC classification number: C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
Abstract: In part, the present invention is directed to antibacterial compounds.
Abstract translation: 部分地，本发明涉及抗菌化合物。
-
3.发明授权Compositions comprising multiple bioactive agents, and methods of using the same 有权包含多种生物活性剂的组合物及其使用方法公开(公告)号：US07879872B2
公开(公告)日：2011-02-01
申请号：US11231298
申请日：2005-09-19
Applicant: Judd M. Berman , Molly B. Schmid , John D. Mendlein , Nachum Kaplan
Inventor： Judd M. Berman , Molly B. Schmid , John D. Mendlein , Nachum Kaplan
IPC: A61K31/554 , A61K31/517 , A61K31/55 , A61K31/4745 , A61K31/496
CPC classification number: A61K45/06 , A61K31/381 , A61K31/4422 , A61K31/4745 , A61K31/496 , A61K31/4965 , A61K31/517 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K2300/00
Abstract: In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.
Abstract translation: 部分地，本发明涉及具有FabI抑制剂和至少一种其它生物活性剂的组合物。 另一方面，本发明涉及具有式I-III化合物和至少一种其它抗菌剂的抗菌组合物。
-
Patent Agency Ranking
4.发明授权公开(公告)号：US07790709B2
公开(公告)日：2010-09-07
申请号：US10537747
申请日：2003-12-05
Applicant: Judd M. Berman , Peter Sampson , Heinz W. Pauls , Jailall Ramnauth , David Douglas Manning , Matthew D. Surman , Dejian Xie , Helene Y. Decornez
Inventor： Judd M. Berman , Peter Sampson , Heinz W. Pauls , Jailall Ramnauth , David Douglas Manning , Matthew D. Surman , Dejian Xie , Helene Y. Decornez
IPC: A01N43/00 , A01N43/62 , A61K31/55 , C07D243/00 , C07D487/22 , C07D491/00 , C07D498/00 , C07D487/00
CPC classification number: C07D213/73 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D495/04
Abstract: In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
Abstract translation: 部分地，本发明涉及式（I）的抗菌化合物，其中A是双环杂芳基环或三环，R 2是杂环残基; L是键，或L是烷基，烯基或环烷基。
-
公开(公告)号：US20100093705A1
公开(公告)日：2010-04-15
申请号：US11628569
申请日：2005-06-06
Applicant: Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
Inventor： Bruce J. Sargent , Henry Pauls , Judd M. Berman , Jailall Ramnauth , Peter Sampson , Andras Toro , Fernando J. Martin , Matthew D. Surman , Helene Y. Decornez , David D. Manning
IPC: A61K31/551 , C07D471/04 , C07D223/16 , C07D491/02 , A61K31/4375 , A61P31/04
CPC classification number: C07D498/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D471/14
Abstract: In part, the present invention is directed to antibacterial compounds.
Abstract translation: 部分地，本发明涉及抗菌化合物。
-
公开(公告)号：US07601526B2
公开(公告)日：2009-10-13
申请号：US11647506
申请日：2006-12-28
Applicant: Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke , Bryan Beattie , Mandy Dorsey
Inventor： Judd M. Berman , Molly B. Schmid , Donald E. Awrey , Teresa Clarke , Bryan Beattie , Mandy Dorsey
CPC classification number: C07K14/195 , C07K2299/00
Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
Abstract translation: 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了从包含SEQ ID NO：2所示氨基酸序列的土拉氏弗斯兰氏菌得到的纯化蛋白质。本发明还提供了本发明多肽的生物化学和生物物理学特征。
-
7.发明申请3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents 审中-公开3-杂环基丙烯酰胺化合物作为Fab I抑制剂和抗菌剂公开(公告)号：US20090156578A1
公开(公告)日：2009-06-18
申请号：US12095977
申请日：2006-12-01
Applicant: Henry Pauls , Judd M. Berman
Inventor： Henry Pauls , Judd M. Berman
IPC: A61K31/553 , C07D405/14 , A61K31/444 , A61K31/44 , C07D471/04 , A61K31/5517 , A61K31/551 , A61K31/55 , A61K31/5383 , C07D487/04 , A61K31/4375 , C07D213/73 , C07D498/04
CPC classification number: C07D405/14 , C07D213/75 , C07D405/12 , C07D413/12 , C07D471/04 , C07D471/14
Abstract: In part, the present invention is directed towards compounds with FabI inhibiting properties. Such compounds may also inhibit other enzymes, including those similar to FabI either structurally or functionally, for example, Fab K. Kits and compositions that include the disclosed compounds are also provided. Methods of treating a subject with a bacterial illness is also disclosed.
Abstract translation: 部分地，本发明涉及具有FabI抑制性质的化合物。 这样的化合物也可以在结构上或功能上抑制其他酶，包括FabI类似物，例如Fab K.试剂盒和包括所公开化合物的组合物。 还公开了治疗患有细菌性疾病的受试者的方法。
-
8.发明申请Compositions Comprising Multiple Bioactive Agents, and Methods of Using the Same 审中-公开包含多种生物活性剂的组合物及其使用方法公开(公告)号：US20120010127A1
公开(公告)日：2012-01-12
申请号：US12962899
申请日：2010-12-08
Applicant: JUDD M. BERMAN , MOLLY B. SCHMID , JOHN D. MENDLEIN , NACHUM KAPLAN
Inventor： JUDD M. BERMAN , MOLLY B. SCHMID , JOHN D. MENDLEIN , NACHUM KAPLAN
IPC: A61K38/14 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61P31/04 , A61K31/444 , A61K31/519 , A61K31/545 , A61K31/65 , A61K31/70 , A61K31/551 , A61K31/5377
CPC classification number: A61K45/06 , A61K31/381 , A61K31/4422 , A61K31/4745 , A61K31/496 , A61K31/4965 , A61K31/517 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K2300/00
Abstract: In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other antibacterial agent.
Abstract translation: 部分地，本发明涉及包含FabI抑制剂和至少一种其它生物活性剂的组合物。 另一方面，本发明涉及包含式I-III化合物和至少一种其它抗菌剂的抗菌组合物。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.042 seconds)
