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公开(公告)号：US20120309809A1
公开(公告)日：2012-12-06
申请号：US13514672
申请日：2010-12-08
Applicant: Matthew Michael James Green , Richard Michael Poole
Inventor： Matthew Michael James Green , Richard Michael Poole
IPC: A61K9/14 , A61K31/404 , B02C23/00 , C07D209/16
CPC classification number: A61K31/4045 , A61K9/0073 , A61K9/14 , A61K9/141 , A61K9/1688
Abstract: A method of processing an active ingredient, the method comprising submitting a pharmaceutically active ingredient in the absence of excipients and/or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the method.
Abstract translation: 一种加工活性成分的方法，所述方法包括在没有赋形剂和/或添加剂的情况下将药物活性成分递送到压缩和剪切力。 本发明还涉及包含通过该方法制备的活性成分的组合物。
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公开(公告)号：US08303991B2
公开(公告)日：2012-11-06
申请号：US12767530
申请日：2010-04-26
IPC: A61K9/14 , A61K31/04 , A61K31/045 , A61K31/40 , A61K47/00
CPC classification number: A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
Abstract translation: 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法，所述方法包括研磨步骤，其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。
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Patent Agency Ranking
公开(公告)号：US09381189B2
公开(公告)日：2016-07-05
申请号：US13514672
申请日：2010-12-08
Applicant: Matthew Michael James Green , Richard Michael Poole
Inventor： Matthew Michael James Green , Richard Michael Poole
IPC: A61K9/14 , A61K31/404 , B02C23/00 , C07D209/16 , A61K31/4045 , A61K9/00
CPC classification number: A61K31/4045 , A61K9/0073 , A61K9/14 , A61K9/141 , A61K9/1688
Abstract: A method of processing an active ingredient, the method comprising submitting a pharmaceutically active ingredient in the absence of excipients and/or additives to compression and shearing forces. The invention also relates to compositions comprising an active prepared by the method.
Abstract translation: 一种加工活性成分的方法，所述方法包括在没有赋形剂和/或添加剂的情况下将药物活性成分递送到压缩和剪切力。 本发明还涉及包含通过该方法制备的活性成分的组合物。
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公开(公告)号：US20100209358A1
公开(公告)日：2010-08-19
申请号：US12767530
申请日：2010-04-26
IPC: A61K9/12 , A61K9/14 , A61K31/225
CPC classification number: A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
Abstract translation: 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法，所述方法包括研磨步骤，其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。
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公开(公告)号：US07736670B2
公开(公告)日：2010-06-15
申请号：US10433072
申请日：2001-11-30
CPC classification number: A61K9/5115 , A61K9/0075 , A61K9/008 , A61K9/145 , A61K9/1617 , A61K9/167 , A61K9/50 , A61K9/501 , A61K9/5015 , A61K9/5089 , A61K31/137 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/32
Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.
Abstract translation: 本发明涉及一种用于制备用于肺部给药的药物组合物的复合活性颗粒的方法，所述方法包括研磨步骤，其中活性物质的颗粒在适于促进的添加剂材料的颗粒存在下研磨 在吸入器致动时复合活性颗粒的分散。 本发明还涉及通过该方法制备的用于吸入的组合物。
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6.发明授权公开(公告)号：US07728166B2
公开(公告)日：2010-06-01
申请号：US10579489
申请日：2004-11-18
Applicant: Peter Finmans , Detlef Hoell , Hans-Jurgen Vossler , Martina Rozek , Michael James Green , Rafael Roggenbuck
Inventor： Peter Finmans , Detlef Hoell , Hans-Jurgen Vossler , Martina Rozek , Michael James Green , Rafael Roggenbuck
IPC: C07C69/66 , C07C309/06
CPC classification number: C07C303/32 , B01J31/0212 , B01J31/0214 , B01J31/0228 , B01J2531/31 , B01J2531/46 , B01J2531/48 , C07C67/03 , C07C67/08 , C07C69/704 , C07C69/70 , C07C69/68 , C07C69/60 , C07C309/06
Abstract: The subject matter of the invention is a process for the production of metal salts of trifluoromethane sulphonic acid by reacting trifluoromethane sulphonic acid with a metal alcoholate and the use thereof as esterification catalyst and/or transesterification catalyst for the production of hydroxycarboxylic acid esters.
Abstract translation: 本发明的主题是通过使三氟甲磺酸与金属醇化物反应制备三氟甲磺酸金属盐的方法及其作为用于制备羟基羧酸酯的酯化催化剂和/或酯交换催化剂的用途。
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公开(公告)号：US07297832B2
公开(公告)日：2007-11-20
申请号：US10539237
申请日：2003-12-19
Applicant: Kevin Blann , Annette Bollmann , John Thomas Dixon , Arno Neveling , David Hedley Morgan , Hulisani Maumela , Esna Killian , Fiona Millicent Hess , Stefanus Otto , Matthew James Overett , Michael James Green
Inventor： Kevin Blann , Annette Bollmann , John Thomas Dixon , Arno Neveling , David Hedley Morgan , Hulisani Maumela , Esna Killian , Fiona Millicent Hess , Stefanus Otto , Matthew James Overett , Michael James Green
CPC classification number: B01J31/188 , B01J31/1608 , B01J31/1616 , B01J31/165 , B01J31/18 , B01J31/1875 , B01J31/2204 , B01J31/2409 , B01J2231/20 , B01J2531/46 , B01J2531/48 , B01J2531/56 , B01J2531/58 , B01J2531/62 , B01J2531/64 , B01J2531/66 , C07C2/36 , C07C2531/24
Abstract: The invention describes a process for tetramerisation of olefins wherein the product stream of the process contains more than 30% of the tetramer olefin. The process includes the step of contacting an olefinic feedstream with a catalyst system containing a transition metal compound and a heteroatomic ligand.
Abstract translation: 本发明描述了烯烃四聚的方法，其中该方法的产物流含有超过30％的四聚烯烃。 该方法包括使烯烃进料流与含有过渡金属化合物和杂原子配体的催化剂体系接触的步骤。
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