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公开(公告)号：US5786350A
公开(公告)日：1998-07-28
申请号：US792035
申请日：1997-01-31
IPC分类号： A61K31/34 , A61K31/395 , A61K31/429 , A61K31/496 , A61K31/519 , A61K31/5377 , A61P31/04 , C07D213/80 , C07D498/08 , C07D498/18 , C07D519/00 , C07D491/08
CPC分类号： C07D213/80
摘要： Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C.sub.1 -C.sub.8)alkyl, halo, hydroxy, (C.sub.1 -C.sub.4)acyloxy, (C.sub.1-C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1-C.sub.4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.
摘要翻译： PCT No.PCT / EP94 / 01428 Sec。 371日期1996年1月22日 102（e）日期1996年1月22日PCT提交1994年5月5日PCT公布。 出版物WO94 / 28002 （Ia）式（I）和（Ia）的利福霉素抗生素衍生物在位置36具有选自（C1-C8）的取代基， 烷基，卤素，羟基，（C1-C4）酰氧基，（C1-C4）烷氧基，（C1-C4）烷硫基，（C1-C4）烷基氨基，二（C1-C4）烷基氨基和取代的4-氧代-3-吡啶基 通过使利福霉素与适当取代的丙二酸反应获得的式（1）的羰基氧基。 本发明的化合物是主要对革兰氏阳性细菌有活性的抗微生物剂和对耐赖菌素抗性微生物菌株具有相当大的抗菌活性的革兰氏阴性细菌。
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公开(公告)号：US5322777A
公开(公告)日：1994-06-21
申请号：US961007
申请日：1992-10-14
CPC分类号： C07K5/06139 , C12R1/01 , A61K38/00
摘要： The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
摘要翻译： 本发明涉及一种新型抗生素物质GE2270，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病。
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公开(公告)号：US4908351A
公开(公告)日：1990-03-13
申请号：US304421
申请日：1989-01-24
IPC分类号： C12P21/02 , A61K38/00 , A61P31/04 , C07H17/00 , C07K1/02 , C07K1/113 , C07K1/22 , C07K9/00 , C07K14/195 , C07K14/41 , A61K37/02 , C07K5/12
CPC分类号： C07K9/008
摘要： The present invention is directed to a new antibiotic substance denominated antibiotic A 42867 pseudoaglycon, a pharmaceutically acceptable salt thereof, a process for its preparation from antibiotic A 42867 and pharmaceutical compositions containing the new substance of the invention.
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公开(公告)号：US6159746A
公开(公告)日：2000-12-12
申请号：US714159
申请日：1996-09-23
申请人： Khalid Islam , Lucia Carrano , Maurizio Denaro
发明人： Khalid Islam , Lucia Carrano , Maurizio Denaro
IPC分类号： G01N33/53 , C07K14/00 , C07K14/47 , C12P21/08 , C12Q1/37 , G01N33/573 , G01N33/577 , G01N33/68 , G01N33/533
CPC分类号： C07K14/47 , G01N33/573 , G01N33/68 , Y10S436/815 , Y10S530/81 , Y10S530/811 , Y10S530/816 , Y10S530/839
摘要： Solid phase immunoassay for detecting specific inhibitors of proteolytic enzymes in biological fluids, which comprises: a) contacting a tubulin peptide covalently linked to a support with a solution containing a proteolytic activity together with a protease inhibitor, b) detecting the inhibitor activity against the selected proteases by contacting the support with a solution containing a labelled monoclonal antibody which specifically recognises the free end of the tubulin peptide linked to the support.
摘要翻译： PCT No.PCT / EP95 / 00867 Sec。 371日期1996年9月23日 102（e）日期1996年9月23日PCT Filed Mar. 9，1995 PCT Pub。 WO95 / 26505 PCT公开号 日期1995年10月5日用于检测生物流体中蛋白水解酶的特异性抑制剂的固相免疫测定法，其包括：a）将与载体共价连接的微管蛋白肽与蛋白酶抑制剂一起含有蛋白水解活性的溶液接触，b） 通过使载体与含有标记的单克隆抗体的溶液接触来抑制所选蛋白酶的活性，所述单克隆抗体特异性识别与载体连接的微管蛋白肽的游离末端。
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5.发明授权Use of tropolone derivatives as inhibitors of the enzyme inositol monophosphatase 有权托普洛尔衍生物作为肌醇单磷酸酶的抑制剂的使用
公开(公告)号：US5990160A
公开(公告)日：1999-11-23
申请号：US312733
申请日：1999-05-14
IPC分类号： A61K31/34 , A61K31/12 , A61K31/122 , A61K31/19 , A61K31/343 , A61P25/18 , A61P43/00 , C12Q1/42 , A01N37/00 , A61K31/185
CPC分类号： C12Q1/42 , A61K31/122 , A61K31/343
摘要： The present invention concerns the use of puberulic or puberulonic acid as inhibitors of the enzyme iositol monophosphatase (EC 3.1.3.25) and thus useful in the treatment of manic or depressive symptoms.
摘要翻译： 本发明涉及作为肌醇单磷酸酶（EC 3.1.3.25）酶的抑制剂的前体和前列腺酸的用途，因此可用于治疗躁狂或抑郁症状。
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6.发明授权Antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T 失效抗生素GE 2270因子B1，B2，C1，C2，D1，D2，E和T
公开(公告)号：US5747295A
公开(公告)日：1998-05-05
申请号：US460177
申请日：1995-06-02
IPC分类号： A61K31/44 , A61K38/00 , A61P3/00 , A61P31/00 , C07D513/22 , C07K5/078 , C12P17/18 , C12P21/04 , C12R1/01 , C12P1/00
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
摘要翻译： 本发明涉及新型抗生素物质GE 2270因子B1，B2，C1，C2，D1，D2，E和T，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗 涉及对它们敏感的微生物的感染性疾病及其作为动物生长促进剂的用途。
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公开(公告)号：US5854036A
公开(公告)日：1998-12-29
申请号：US716259
申请日：1996-09-10
IPC分类号： C12Q1/42 , A61K31/34 , A61K35/74 , A61P25/24 , A61P25/26 , C07D307/94 , C07G99/00 , C12P17/04 , C12R1/645
CPC分类号： C07D307/94 , C12P17/04
摘要： The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.
摘要翻译： PCT No.PCT / EP95 / 01045 Sec。 371日期：1996年9月10日 102（e）1996年9月10日PCT 1995年3月21日PCT PCT。 公开号WO95 / 26344 日期1995年10月5日本发明涉及通过发酵Memnonoiella或Stachybotrys的微生物获得的新型化合物，该化合物是肌醇单磷酸酶的抑制剂（EC 3.1.3.25）。 本发明还涉及这些新化合物在治疗躁狂抑郁症中的用途以及包含所述化合物作为活性成分的药物制剂; 另一个目的是在检测肌醇单磷酸酶的分析方法中使用这些化合物。
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公开(公告)号：US5843890A
公开(公告)日：1998-12-01
申请号：US462997
申请日：1995-06-05
IPC分类号： A61K31/44 , A61K38/00 , A61P3/00 , A61P31/00 , C07D513/22 , C07K5/078 , C12P17/18 , C12P21/04 , C12R1/01 , A61K35/70
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
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公开(公告)号：US5610143A
公开(公告)日：1997-03-11
申请号：US493043
申请日：1995-06-21
申请人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
发明人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
CPC分类号： C07K5/0821 , A23K20/195 , C07K5/06139 , C12R1/465 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
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公开(公告)号：US5567676A
公开(公告)日：1996-10-22
申请号：US457365
申请日：1995-06-01
申请人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
发明人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
IPC分类号： C12P21/02 , A61K38/00 , A61P31/04 , C07G11/00 , C07K20060101 , C07K9/00 , C07K14/195 , C07K14/41 , C12R1/045 , A61K38/14 , A61K38/12
CPC分类号： C07K9/008
摘要： The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.
摘要翻译： 本发明涉及脱酰基抗生素A40926，去酰基抗生素A40926P和抗生素A40926氨基葡糖苷酸苷的新抗生素物质，以及这些物质用于治疗涉及对其敏感的微生物的感染性疾病的用途。
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