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公开(公告)号：US20050136067A1
公开(公告)日：2005-06-23
申请号：US10842032
申请日：2004-05-10
申请人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
发明人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
IPC分类号： A61K39/00 , A61K39/155 , A61K39/295 , A61P11/00 , A61P31/12 , A61P31/16 , A61P37/04 , C07K1/22 , C07K14/005 , C07K14/11 , C07K14/115 , C07K14/135 , C07K14/19 , C07K14/195 , C07K14/41 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/33 , C12N15/45 , G01N33/53 , G01N33/569 , C12Q1/70 , A61K39/12 , A61K39/145 , C07H21/04 , C12N7/00 , C12N15/86
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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公开(公告)号：US20080027213A1
公开(公告)日：2008-01-31
申请号：US11808807
申请日：2007-06-13
申请人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
发明人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
IPC分类号： C07K14/005
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US20080032342A1
公开(公告)日：2008-02-07
申请号：US11808802
申请日：2007-06-13
申请人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
发明人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US20080015340A1
公开(公告)日：2008-01-17
申请号：US11808800
申请日：2007-06-13
申请人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
发明人： Michel Klein , Run-Pan Du , Mary Ewasyshyn
IPC分类号： C07K14/005
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体尤其是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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