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公开(公告)号：US07868141B2
公开(公告)日：2011-01-11
申请号：US12315863
申请日：2008-12-05
申请人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
发明人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译： 本发明涉及抗OX40L抗体，特别涉及抗OX40L抗体及其变体，其含有源自人源的Fc部分，并且不结合补体因子C1q。 这些抗体具有新的和本发明的性质，为患有炎性疾病的患者带来益处。
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公开(公告)号：US20100166740A1
公开(公告)日：2010-07-01
申请号：US12315863
申请日：2008-12-05
申请人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van de Winkel , Martine Van Vugt
发明人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van de Winkel , Martine Van Vugt
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译： 本发明涉及抗OX40L抗体，特别涉及抗OX40L抗体及其变体，其含有源自人源的Fc部分，并且不结合补体因子C1q。 这些抗体具有新的和本发明的性质，为患有炎性疾病的患者带来益处。
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3.发明申请公开(公告)号：US20120322732A1
公开(公告)日：2012-12-20
申请号：US13551648
申请日：2012-07-18
申请人： Beat Amrein , Stefan Foser , Kurt Lang , Friedrich Metzger , Joerg Regula , Andreas Schaubmar , Friederike Hesse , Klaus-Peter Kuenkele , Martin Lanzendoerfer
发明人： Beat Amrein , Stefan Foser , Kurt Lang , Friedrich Metzger , Joerg Regula , Andreas Schaubmar , Friederike Hesse , Klaus-Peter Kuenkele , Martin Lanzendoerfer
CPC分类号： A61K47/60 , C07K14/475 , C07K14/65
摘要： A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.
摘要翻译： 由胰岛素样生长因子-1（IGF-I）变体和一个或两个聚（乙二醇）基团组成的缀合物，其特征在于所述IGF-1变体在至多三个氨基酸处具有氨基酸改变 野生型IGF-I氨基酸序列的酸性位置27,37,65,68，使得一个或两个所述氨基酸是赖氨酸，氨基酸27是极性氨基酸而不是赖氨酸，通过 公开了所述赖氨酸和所述聚（乙二醇）基团的伯氨基的总分子量为20至100kDa。 该缀合物可用于治疗神经变性疾病如阿尔茨海默病。
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4.发明授权Method for the purification of an N-terminal fragment of hepatocyte growth factor 失效纯化肝细胞生长因子的N-末端片段的方法公开(公告)号：US07544493B2
公开(公告)日：2009-06-09
申请号：US10591040
申请日：2005-03-02
CPC分类号： C07K14/4753
摘要： A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell, isolation of inclusion bodies containing said NK4 in denatured form, solubilization of the inclusion bodies and naturation of the denatured NK4, characterized in that solubilization and naturation are performed at pH 7-9 in phosphate buffered solution, provides NK4 in high purity and high yield.
摘要翻译： 通过在微生物宿主细胞中表达编码所述NK4的核酸，分离含有所述变性的所述NK4的包含体的方法，用于生产含有肝素细胞生长因子（NK4）的N末端四克隆片段的片段， 包涵体和变性NK4的生成，其特征在于在磷酸盐缓冲溶液中在pH7-9下进行溶解和生成，提供高纯度和高产率的NK4。
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5.发明申请Conjugates of the c domain of human gelatinase a and polyethylene glycol, methods of purification and uses thereof 审中-公开人类明胶酶a和聚乙二醇的c结构域的缀合物，其纯化方法和用途公开(公告)号：US20050153416A1
公开(公告)日：2005-07-14
申请号：US10505990
申请日：2003-02-28
CPC分类号： C12N9/6491 , A61K38/4886 , A61K47/60
摘要： There is provided a conjugate comprising the C domain of human gelatinase A (PEX domain, PEX) and one to three poly(ethylene glycol) group(s), said poly(ethylene glycol) group(s) having an overall weight of from about 10 to 40 kDa and being conjugated via primary amino group(s) of said PEX. The conjugates are useful as anticancer agents.
摘要翻译： 提供了包含人明胶酶A（PEX结构域，PEX）和一至三个聚（乙二醇）基团的C结构域的共轭物，所述聚（乙二醇）基团的总重量为约 10至40kDa，并通过所述PEX的伯氨基共轭。 缀合物可用作抗癌剂。
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公开(公告)号：US20110070239A1
公开(公告)日：2011-03-24
申请号：US12958278
申请日：2010-12-01
申请人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
发明人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/074
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译： 本发明涉及抗OX40L抗体，特别涉及抗OX40L抗体及其变体，其含有源自人源的Fc部分，并且不结合补体因子C1q。 这些抗体具有新的和本发明的性质，为患有炎性疾病的患者带来益处。
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7.发明申请公开(公告)号：US20060154865A1
公开(公告)日：2006-07-13
申请号：US11313101
申请日：2005-12-20
申请人： Beat Amrein , Stefan Foser , Kurt Lang , Friedrich Metzger , Joerg Regula , Andreas Schaubmar , Friederike Hesse , Klaus-Peter Kuenkele , Martin Lanzendoerfer
发明人： Beat Amrein , Stefan Foser , Kurt Lang , Friedrich Metzger , Joerg Regula , Andreas Schaubmar , Friederike Hesse , Klaus-Peter Kuenkele , Martin Lanzendoerfer
CPC分类号： A61K47/60 , C07K14/475 , C07K14/65
摘要： A conjugate consisting of an insulin-like growth factor-1 (IGF-I) variant and one or two poly(ethylene glycol) group(s), characterized in that said IGF-I variant has an amino acid alteration at up to three amino acid positions 27, 37, 65, 68 of the wild-type IGF-I amino acid sequence so that one or two of said amino acids is/are lysine and amino acid 27 is a polar amino acid but not lysine, is conjugated via the primary amino group(s) of said lysine(s) and said poly(ethylene glycol) group(s) have an overall molecular weight of from 20 to 100 kDa is disclosed. This conjugate is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.
摘要翻译： 由胰岛素样生长因子-1（IGF-I）变体和一个或两个聚（乙二醇）基团组成的缀合物，其特征在于所述IGF-1变体在最多三个氨基酸处具有氨基酸改变 野生型IGF-I氨基酸序列的酸性位置27,37,65,68，使得一个或两个所述氨基酸是赖氨酸，氨基酸27是极性氨基酸而不是赖氨酸，通过 公开了所述赖氨酸和所述聚（乙二醇）基团的伯氨基的总分子量为20至100kDa。 该缀合物可用于治疗神经变性疾病如阿尔茨海默病。
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公开(公告)号：US20050118169A1
公开(公告)日：2005-06-02
申请号：US10937596
申请日：2004-09-09
申请人： Ilse Bartke , Francis Carr , Richard Chizzonite , Elsie Eugui , Georg Fertig , Anita Hamilton , Martin Lanzendoerfer , Petra Rueger , Ralf Schumacher , Theresa Truitt
发明人： Ilse Bartke , Francis Carr , Richard Chizzonite , Elsie Eugui , Georg Fertig , Anita Hamilton , Martin Lanzendoerfer , Petra Rueger , Ralf Schumacher , Theresa Truitt
IPC分类号： A61K39/395 , C07H21/04 , C07K16/28 , C12N5/06 , C12N15/13
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis.
摘要翻译： 本发明涉及抗白细胞介素-1受体（IL-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 本发明的抗体特别可用于治疗各种炎性疾病，包括但不限于类风湿性关节炎。
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公开(公告)号：US20110183354A1
公开(公告)日：2011-07-28
申请号：US13037823
申请日：2011-03-01
申请人： ULRICH BRINKMANN , PETER BRUENKER , CLAUDIA FERRARA KOLLER , MARTIN LANZENDOERFER , JOERG THOMAS REGULA , TILMAN SCHLOTHAUER , STEFAN SEEBER , ANNE ZECK
发明人： ULRICH BRINKMANN , PETER BRUENKER , CLAUDIA FERRARA KOLLER , MARTIN LANZENDOERFER , JOERG THOMAS REGULA , TILMAN SCHLOTHAUER , STEFAN SEEBER , ANNE ZECK
IPC分类号： G01N33/566 , C12P21/02 , C07K14/735
CPC分类号： C07K14/70535 , G01N2333/70535
摘要： The present invention relates to the field of human immunoglobulin receptors, specifically the glycostructure of a human Fc gamma receptor IIIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.
摘要翻译： 本发明涉及人免疫球蛋白受体的领域，特别涉及人胚胎肾细胞和中国仓鼠卵巢细胞中重组表达的人Fcγ受体IIIa的糖结构。
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公开(公告)号：US20110165156A1
公开(公告)日：2011-07-07
申请号：US12962445
申请日：2010-12-07
申请人： NIKOLAOS DIMOUDIS , GEORG FERTIG , ALEXANDER FIDLER , KLAUS KALUZA , MARLENE PICKL , CAROLA RIES , STEFAN SEEBER , MARTIN LANZENDOERFER , KERSTIN KRUEGER
发明人： NIKOLAOS DIMOUDIS , GEORG FERTIG , ALEXANDER FIDLER , KLAUS KALUZA , MARLENE PICKL , CAROLA RIES , STEFAN SEEBER , MARTIN LANZENDOERFER , KERSTIN KRUEGER
IPC分类号： A61K39/395 , C07K16/40 , C07H21/00 , A61P29/00 , A61P35/00 , A61P19/08 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/04
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies against human CSF-1R (anti-CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CSF-1R（抗CSF-1R抗体）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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