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    HEART VALVE PROSTHESIS AND METHOD
    1.
    发明申请
    HEART VALVE PROSTHESIS AND METHOD 审中-公开
    心脏瓣膜假体和方法

    公开(公告)号：US20120101571A1

    公开(公告)日：2012-04-26

    申请号：US13130180

    申请日：2009-11-20

    申请人： Suku Thambar ,  Martin Christopher Cook ,  Stefan Schreck ,  Stayajit Rohan Jayasinghe

    发明人： Suku Thambar ,  Martin Christopher Cook ,  Stefan Schreck ,  Stayajit Rohan Jayasinghe

    IPC分类号： A61F2/24

    CPC分类号： A61B17/0057 ,  A61B2017/00575 ,  A61B2017/0061 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61F2002/8486 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/006

    摘要： A heart valve prosthesis (100) comprises a housing component (110) and a valve component (130). The housing component (110) comprises a housing body (111) having a housing passage (112) extending therethrough. The housing body (111) is configured to be located in, or adjacent to and communicating with, a native valve orifice (16) of a heart (10) and to engage structure of the heart (10) to fix the housing body (111) in relation to the valve orifice (161). The housing component (111) is collapsible for delivery via catheter (2). The valve component (130) comprises a valve body (131) having a valve passage (132) extending therethrough. The valve body (131) is configured to be fixed within the housing passage (112) with the valve passage (132) extending along the housing passage (112). One or more flexible valve elements (131) is/are secured to the valve body and extend across the valve passage (132) for blocking blood flow in a first direction through the valve passage (132) whilst allowing blood flow in the opposing direction. The valve component (130) is collapsible for delivery via catheter (2) separate to the housing component (110). An associated method of replacing a failed or failing heart valve utilising the heart valve prosthesis (100) is also disclosed.

    摘要翻译： 心脏瓣膜假体（100）包括壳体部件（110）和阀部件（130）。 壳体部件（110）包括具有延伸穿过其的壳体通道（112）的壳体（111）。 壳体（111）构造成位于心脏（10）的天然瓣膜（16）中或邻近并连通，并与心脏（10）的结构接合以固定壳体（111） ）相对于阀孔（161）。 壳体部件（111）可折叠以便经由导管（2）输送。 阀部件（130）包括具有延伸穿过其中的阀通道（132）的阀体（131）。 阀体（131）构造成固定在壳体通道（112）内，阀通道（132）沿壳体通道（112）延伸。 一个或多个柔性阀元件（131）被固定到阀体并延伸穿过阀通道（132），用于阻止通过阀通道（132）的第一方向的血流，同时允许血液沿相反方向流动。 阀部件（130）可折叠以便通过分离到壳体部件（110）的导管（2）输送。 还公开了利用心脏瓣膜假体（100）代替故障或故障心脏瓣膜的相关方法。

    3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof
    3.
    发明授权
    3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxymethoxyimino-2-(fur-2-yl or thien-2-yl)acetamido]ceph-3-em-4-carboxylic acids and derivatives thereof 失效
    3-羧基甲酰基甲基或N-甲基 - 羧基甲酰基甲基-7-（2-羧基甲酰胺亚氨基-2-（FUR-2-YL或THIEN-2-YL）ACETAMIDO）CEPH-3-EM-4-羧酸及其衍生物

    公开(公告)号：US4095021A

    公开(公告)日：1978-06-13

    申请号：US668244

    申请日：1976-03-18

    申请人： Janice Bradshaw ,  Martin Christopher Cook ,  Gordon Ian Gregory

    发明人： Janice Bradshaw ,  Martin Christopher Cook ,  Gordon Ian Gregory

    IPC分类号： C07D307/54 ,  C07D333/24 ,  C07D501/20 ,  C07D501/34 ,  A61K31/545

    CPC分类号： C07D307/54 ,  C07D333/24

    摘要： Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure ##STR1## (where R is thienyl or furyl; R.sup.a and R.sup.b are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; and m and n are each 0 or 1 such that the sum of m and n is 0 or 1) exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce .beta.-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly high in vitro activity against strains of Escherichia coli, Haemophilus influenzae and Proteus organisms; compounds wherein at least one of R.sup.a and R.sup.b is other than hydrogen have also shown unusually high activity against Pseudomonas organisms. Important compounds of the above type include those in which the 7.beta.-acylamido group is a syn-2-carboxymethoxy-2-(fur-2-yl)acetamido, syn-2-(2-carboxyprop-2-yloxyimino)-2-(fur-2-yl)acetamido or syn-2-(1-carboxycyclopent-1-yloxyimino)-2-(fur-2-yl)acetamido group.

    摘要翻译： 头孢菌素抗生素，其中7β-酰胺基具有结构

    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7
    4.
    发明授权
    Syn isomers of cephalosporins having .alpha.-hydroximino- or .alpha.-acyloxyiminoacylamido groups at position-7 失效
    在7-位上具有{60-羟肟基 - 或{6-氰酰氧基亚氨酰基酰胺基的头孢菌素的Syn异构体

    公开(公告)号：US4024134A

    公开(公告)日：1977-05-17

    申请号：US554014

    申请日：1975-02-28

    申请人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    发明人： Michael Gregson ,  Martin Christopher Cook ,  Gordon Ian Gregory

    IPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24 ,  C07D501/20

    CPC分类号： C07C259/02 ,  C07D307/54 ,  C07D333/24

    摘要： The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof, and 6.beta.-acylamidopenam-3-carboxylic acids, and non-toxic derivatives thereof, characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is a hydrogen atom or an acyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

    摘要翻译： 本发明提供了新的抗生素化合物，它们是7β-酰基酰胺基头孢-3-烯-4-羧酸及其无毒衍生物，和6β-酰基氨基青蒿素-3-羧酸及其无毒衍生物，其特征在于 酰胺基具有结构

    7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
    5.
    发明授权
    7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids 失效
    7-烃氧基亚氨基乙酰氨基-3-氨基甲酰氧甲基头孢-3-烯-4-羧酸

    公开(公告)号：US3974153A

    公开(公告)日：1976-08-10

    申请号：US497113

    申请日：1974-08-13

    申请人： Martin Christopher Cook ,  Gordon Ian Gregory ,  Janice Bradshaw

    发明人： Martin Christopher Cook ,  Gordon Ian Gregory ,  Janice Bradshaw

    IPC分类号： C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D501/26 ,  C07D501/60

    CPC分类号： C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D501/26

    摘要： Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure ##EQU1## where R.sup.1 is a furyl, thienyl or phenyl group and R.sup.2 is a C.sub.1 -C.sub.4 alkyl, C.sub.3 C.sub.7 cycloalkyl or phenyl group and in which the 3-position substituent is a carbamoyloxymethyl group possess a particularly valuable combination of properties, exhibiting high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer. Particularly important compounds of this type are (6R,7R)-3-carbamoyloxymethyl -7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (syn isomer) and its non-toxic derivatives, e.g. the sodium salt.

    摘要翻译： 头孢菌素抗生素，其中7个β-酰基酰氨基具有结构R1.C.CO.NH-并环N | OR2，其中R1是呋喃基，噻吩基或苯基，R2是C1-C4烷基，C3C7环烷基或苯基， 其中3-位取代基是氨基甲酰氧基甲基具有特别有价值的性质组合，对广泛的革兰氏阳性和革兰氏阴性生物表现出高抗菌活性，特别是对各种生物体产生的β-内酰胺酶具有高稳定性，并且稳定性 体内。 这些化合物是顺式异构体，或作为含有至少90％的顺式异构体的顺式和反异构体的混合物存在。 这种类型的特别重要的化合物是（6R，7R）-3-氨基甲酰氧基甲基-7- [2-（呋喃-2-基）-2-甲氧基亚氨基乙酰胺基]环庚-3-烯-4-羧酸（顺式异构体）及其 无毒的衍生物，例如 钠盐。

    7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
    6.
    发明授权
    7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof 失效
    7- {62-酰氨基-3-氨基甲酰氧基甲基头孢-3-烯-4-羧酸及其盐

    公开(公告)号：US3966717A

    公开(公告)日：1976-06-29

    申请号：US413970

    申请日：1973-11-08

    申请人： Martin Christopher Cook ,  Gordon Ian Gregory ,  Janice Bradshaw

    发明人： Martin Christopher Cook ,  Gordon Ian Gregory ,  Janice Bradshaw

    IPC分类号： C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D501/34 ,  C07D501/20

    CPC分类号： C07D307/42 ,  C07D307/54 ,  C07D307/79 ,  C07D501/26

    摘要： The invention provides novel antibiotic compounds comprising 7.beta.-acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and non-toxic derivatives thereof wherein the acylamido group has the structure ##EQU1## IN WHICH R is a carbocyclic or heterocyclic aryl group and R.sup.a is a lower alkyl, cycloalkyl or phenyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various organisms and stability in the presence of human serum. The invention is also concerned with the administration of the compounds.

    摘要翻译： 本发明提供了包含7个β-酰氨基-3-氨基甲酰氧基甲基头孢-3-烯-4-羧酸及其无毒衍生物的新型抗生素化合物，其中酰氨基具有RCCO结构.N-和 碳环或杂环芳基，Ra是低级烷基，环烷基或苯基。 这些化合物是顺式异构体，或作为含有至少75％的顺式异构体的混合物存在。 这些抗生素化合物对一系列革兰氏阳性和革兰氏阴性生物具有高抗菌活性，与各种生物体产生的β-内酰胺酶具有特别高的稳定性，并在人血清存在下具有稳定性。 本发明还涉及化合物的给药。