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1.发明授权Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism 有权纤溶酶原激活物抑制剂-1抑制剂及其用于调节脂质代谢的方法公开(公告)号：US08759327B2
公开(公告)日：2014-06-24
申请号：US12104409
申请日：2008-04-16
申请人： Daniel A. Lawrence , Dudley Strickland , Jacqueline Cale , Enming J. Su , Cory Emal , Mark Warnock
发明人： Daniel A. Lawrence , Dudley Strickland , Jacqueline Cale , Enming J. Su , Cory Emal , Mark Warnock
IPC分类号： G01N33/566 , A61K31/60 , A61K31/235 , A61K31/192 , A61K31/195 , A61K31/352 , C07D317/04 , C07C69/773 , C07C62/04 , C07C333/02 , A61P3/10 , A61P9/10 , A61P35/00
CPC分类号： C07C311/29 , C07C69/88 , C07C271/22 , C07C2601/14 , C07H13/08 , G01N33/92 , G01N2333/8132 , G01N2500/02
摘要： The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
摘要翻译： 本发明涉及纤溶酶原激活物-1（PAI-1）抑制剂化合物及其用于治疗与PAI-1升高相关的任何疾病或病症的用途。 本发明包括但不限于使用这些化合物来调节脂质代谢和治疗与升高的PAI-1，胆固醇或脂质水平相关的病症。
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2.发明申请Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism 有权纤溶酶原激活物抑制剂-1抑制剂及其使用方法调节脂质代谢公开(公告)号：US20100137194A1
公开(公告)日：2010-06-03
申请号：US12624126
申请日：2009-11-23
申请人： Daniel A. Lawrence , Cory Emal , Jacqueline Cale , Enming J. Su , Mark Warnock , Shih-Hon Li , Jeanne A. Cupp
发明人： Daniel A. Lawrence , Cory Emal , Jacqueline Cale , Enming J. Su , Mark Warnock , Shih-Hon Li , Jeanne A. Cupp
IPC分类号： A61K38/16 , C07C69/76 , A61K31/235 , C07C233/64 , A61K31/166 , C07D401/12 , A61K31/444 , C07D241/04 , A61K31/4965 , C07D237/04 , A61K31/50 , C07D265/30 , A61K31/5375 , C07D311/00 , A61K31/351 , C07H15/203 , A61K31/7028 , A61P3/10 , A61P3/04 , A61P25/28 , A61P9/04 , A61P19/02
CPC分类号： C07H15/203 , A61K31/166 , A61K31/18 , A61K31/235 , A61K31/27 , A61K31/444 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/7034 , A61K38/1741 , A61K38/482 , C07C69/88 , C07C69/90 , C07C69/94 , C07C229/12 , C07C229/34 , C07C235/68 , C07C271/22 , C07C271/54 , C07C311/29 , C07C311/49 , C07C2601/14 , C07D213/82 , C07D295/192 , C07D295/195 , C07D295/26 , C07H13/08 , C12Y304/21073
摘要： The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
摘要翻译： 本发明涉及纤溶酶原激活物-1（PAI-1）抑制剂化合物及其用于治疗与PAI-1升高相关的任何疾病或病症的用途。 本发明包括但不限于使用这些化合物来调节脂质代谢和治疗与升高的PAI-1，胆固醇或脂质水平相关的病症。
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3.发明授权公开(公告)号：US09120744B2
公开(公告)日：2015-09-01
申请号：US12624126
申请日：2009-11-23
申请人： Daniel A. Lawrence , Cory Emal , Jacqueline Cale , Enming J. Su , Mark Warnock , Shih-Hon Li , Jeanne A. Cupp
发明人： Daniel A. Lawrence , Cory Emal , Jacqueline Cale , Enming J. Su , Mark Warnock , Shih-Hon Li , Jeanne A. Cupp
IPC分类号： C07C311/29 , C07C69/88 , C07C69/90 , C07C229/12 , C07C229/34 , C07C271/22 , C07C271/54 , C07H13/08
CPC分类号： C07H15/203 , A61K31/166 , A61K31/18 , A61K31/235 , A61K31/27 , A61K31/444 , A61K31/495 , A61K31/50 , A61K31/5375 , A61K31/7034 , A61K38/1741 , A61K38/482 , C07C69/88 , C07C69/90 , C07C69/94 , C07C229/12 , C07C229/34 , C07C235/68 , C07C271/22 , C07C271/54 , C07C311/29 , C07C311/49 , C07C2601/14 , C07D213/82 , C07D295/192 , C07D295/195 , C07D295/26 , C07H13/08 , C12Y304/21073
摘要： The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
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4.发明申请Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism 有权纤溶酶原激活物抑制剂-1抑制剂及其使用方法调节脂质代谢公开(公告)号：US20090011055A1
公开(公告)日：2009-01-08
申请号：US12104409
申请日：2008-04-16
申请人： Daniel A. Lawrence , Dudley Strickland , Jacqueline Cale , Enming J. Su , Cory Emal , Mark Warnock
发明人： Daniel A. Lawrence , Dudley Strickland , Jacqueline Cale , Enming J. Su , Cory Emal , Mark Warnock
IPC分类号： A61K36/82 , G01N33/566 , A61K31/60 , A61K31/235 , C07D317/04 , C07C62/04 , A61P3/10 , A61P35/00 , A61P9/10 , C07C333/02 , C07C69/773 , A61K31/352 , A61K31/192 , A61K31/195
CPC分类号： C07C311/29 , C07C69/88 , C07C271/22 , C07C2601/14 , C07H13/08 , G01N33/92 , G01N2333/8132 , G01N2500/02
摘要： The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.
摘要翻译： 本发明涉及纤溶酶原激活物-1（PAI-1）抑制剂化合物及其用于治疗与PAI-1升高相关的任何疾病或病症的用途。 本发明包括但不限于使用这些化合物来调节脂质代谢和治疗与升高的PAI-1，胆固醇或脂质水平相关的病症。
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