摘要:
Disclosed herein are methods of treating diseases and disorders responsive to inhibition of Hsp90, pharmaceutical compositions, pharmaceutical dosage forms and medicaments useful for the treatment of diseases responsive to inhibition of Hsp90, and methods of making the pharmaceutical compositions, pharmaceutical dosage forms and medicaments.
摘要:
Provided herein are methods of treating Parkinson's disease, dementia with Lewy bodies, and conditions associated with Parkinson's disease and dementia with Lewy bodies. These methods include administering to a subject in need thereof a therapeutically effective amount of a tissue kallikrein (KLK1) polypeptide, including active variants and fragments thereof.
摘要:
The invention relates to high drug load formulations containing (R)-2-(2-fluoro-4-biphenylyl)propionic acid as an active pharmaceutical ingredient.
摘要:
A snowshoe of molded plastic material has a tail section with greater flexibility than the main body section, thereby allowing the tail to give and deform as the snowshoe tail is engaged against the terrain during the gait of the user. At the same time, the tail is stiff enough to provide flotation needed when the full weight of the user is on one snowshoe fully engaged against terrain, such as soft snow.
摘要:
A system and method for parallel-beam scanning a surface. An energetic beam source emits an energetic collimated beam which is received by an optical device, comprising: one or more optical media, operable to receive the emitted beam, such as two pairs of coordinated mirrors or a right prism, and at least one actuator coupled to the one or more optical media, and operable to rotate each of the one or more optical media around a respective axis to perform a parallel displacement of the beam in a respective direction, wherein the respective direction, the beam, and the respective axis are mutually orthogonal. The optical device is operable to direct the beam to illuminate a sequence of specified regions of a surface.
摘要:
A skate upper (120) of the type having an elongate vamp (122) with lace keepers (123) and a tongue (130) disposed generally in the vamp is provided with an attached lace locker. The lace locker (150) fixedly attached near the top of the upper, preferably to an upper portion of the tongue. A lace (124) is retained by the lace keepers and releasably engaged by the lace locker. A strap assembly (126) is provided below the lace locker. A lace guide (140) is attached to the tongue, below the lace locker and below the strap assembly. The invention positions the lace locker more conveniently above the strap assembly, and permits the user to tighten and loosen the lace with one hand.
摘要:
The disclosed subject matter comprises a display retention bracket (DRB) that can be attached to, and can retain and horizontally mount, a display using display retention components, without using fasteners, for insertion of the display in a bezel that does not support horizontal mounting; and includes: a cable retention component that enables the cable to withstand a specified pull-out force to maintain connection of the cable to the display; a cable guide to maintain cable wires in a desired position in relation to other components; alignment pins to align the DRB and display with a bezel housing; non-symmetrical tabs to ensure the display is oriented correctly; offset columns that desirably offset loads on the display when an adapter plate is applied onto the DRB and display, and fastened to the bezel to secure the display; and a ground clip to extend the ground path from the bezel to the display.
摘要:
A translating die apparatus and method for forming a piece of material into a part having complex contours. The translating die apparatus may comprise upper and lower mounts, fixed upper and lower dies fixed to the upper and lower mounts, respectively, and movable upper and lower dies translatably coupled with the mounts and configured to translate laterally toward and away from the fixed upper and lower dies. The piece of material may be placed between the upper and lower dies and one of the mounts may be actuated toward another of the mounts to sandwich the piece of material between the upper and lower dies. Simultaneously, the movable upper and lower dies may translate toward the fixed upper and lower dies, until the movable and fixed dies abut each other when the upper and lower dies are fully pressing the piece of material therebetween.
摘要:
A translating die apparatus and method for forming a piece of material into a part having complex contours. The translating die apparatus may comprise upper and lower mounts, fixed upper and lower dies fixed to the upper and lower mounts, respectively, and movable upper and lower dies translatably coupled with the mounts and configured to translate laterally toward and away from the fixed upper and lower dies. The piece of material may be placed between the upper and lower dies and one of the mounts may be actuated toward another of the mounts to sandwich the piece of material between the upper and lower dies. Simultaneously, the movable upper and lower dies may translate toward the fixed upper and lower dies, until the movable and fixed dies abut each other when the upper and lower dies are fully pressing the piece of material therebetween.