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    "> Cyclohexane-1,2'-Indene-1',2
    1.
    发明申请
    Cyclohexane-1,2'-Indene-1',2"-Imidazol Compounds and Their Use as Bace Inhibitors 有权
    环己烷-1,2'-茚-1'，2“ - 咪唑化合物及其作为阻止剂的用途

    公开(公告)号：US20130345247A1

    公开(公告)日：2013-12-26

    申请号：US13916701

    申请日：2013-06-13

    申请人： Sofia Karlstrom ,  Peter Soderman ,  Laszlo Rakos ,  Liselotte Ohberg ,  Karin Kolmodin ,  Lars Sandberg

    发明人： Sofia Karlstrom ,  Peter Soderman ,  Laszlo Rakos ,  Liselotte Ohberg ,  Karin Kolmodin ,  Lars Sandberg

    IPC分类号： C07D235/02 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/4184 ,  C07D401/04

    CPC分类号： C07D235/02 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/02 ,  C07D401/04

    摘要： Cyclohexane-1,2′-indene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.

    摘要翻译： 环己烷-1,2'-茚-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病， 阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹 或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

    "> Cyclohexane-1,2'-Naphthalene-1',2
    3.
    发明申请
    Cyclohexane-1,2'-Naphthalene-1',2"-Imidazol Compounds and Their Use as Bace 有权
    环己烷-1,2'-萘-1'，2“ - 咪唑化合物及其作为Bace的用途

    公开(公告)号：US20130345248A1

    公开(公告)日：2013-12-26

    申请号：US13916731

    申请日：2013-06-13

    申请人： Sofia Karlstrom ,  Lars Sandberg ,  Peter Soderman ,  Karin Kolmodin ,  Liselotte Ohberg

    发明人： Sofia Karlstrom ,  Lars Sandberg ,  Peter Soderman ,  Karin Kolmodin ,  Liselotte Ohberg

    IPC分类号： C07D235/02 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/4184 ,  C07D401/04

    CPC分类号： C07D235/02 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/02 ,  C07D401/04 ,  C07D491/107

    摘要： Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.

    摘要翻译： 环己烷-1,2'-萘-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病， 阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹 或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

    Cycloalkyl Ether Compounds and Their Use as Bace Inhibitors
    4.
    发明申请
    Cycloalkyl Ether Compounds and Their Use as Bace Inhibitors 有权
    环烷基醚化合物及其作为抑制剂的用途

    公开(公告)号：US20130345272A1

    公开(公告)日：2013-12-26

    申请号：US13916740

    申请日：2013-06-13

    申请人： Sofia Karlstrom ,  Peter Soderman ,  Britt-Marie Swahn ,  Laszlo Rakos ,  Liselotte Ohberg

    发明人： Sofia Karlstrom ,  Peter Soderman ,  Britt-Marie Swahn ,  Laszlo Rakos ,  Liselotte Ohberg

    IPC分类号： C07D235/02 ,  A61K45/06 ,  A61K31/428

    CPC分类号： C07D235/02 ,  A61K31/428 ,  A61K45/06

    摘要： Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration and pharmaceutical compositions containing such compounds.

    摘要翻译： 环烷基醚化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，神经变性 与诸如阿尔茨海默病或痴呆的疾病相关，包括混合血管和退行性疾病的痴呆，老年痴呆，老年性痴呆和与帕金森病相关的老年痴呆，进行性核上性麻痹或皮层基底变性以及含有这些化合物的药物组合物。