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    Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
    4.
    发明授权
    Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals 失效
    细菌菌株，基因和酶通过淬灭群体感应信号来控制细菌性疾病

    公开(公告)号：US07888493B2

    公开(公告)日：2011-02-15

    申请号：US11972777

    申请日：2008-01-11

    申请人： Lianhui Zhang ,  Yihu Dong ,  Haibao Zhang ,  Jinling Xu

    发明人： Lianhui Zhang ,  Yihu Dong ,  Haibao Zhang ,  Jinling Xu

    IPC分类号： C07H21/04 ,  C12N15/70 ,  C12N5/16 ,  C12N1/20 ,  C07K17/00

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C12N15/8281

    摘要： The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting of 104HXHXDH109˜60aa˜H169˜21aa˜D191 and 103HXHXDH108˜72aa˜H180˜21aa˜D202, and to expression vectors and transformed plant and animal cells comprising the same. The proteins encoded by these nucleic acid molecules provide to a susceptible plant or animal increased resistance to a disease the virulence of which is regulated by autoinducers. Also provided are methods of increasing disease resistance in susceptible plants and animals.

    摘要翻译： 本发明涉及编码自身诱导失活蛋白的分离的核酸分子，其中编码的蛋白质包含选自以下的氨基酸序列：104HXHXDH109〜60aa〜H169〜21aa〜D191和103HXHXDH108〜72aa〜H180〜21aa〜D220， 以及表达载体和包含其的转化的植物和动物细胞。 由这些核酸分子编码的蛋白质提供给敏感植物或动物增加的抗病毒性，其毒性由自动诱导剂调节。 还提供了在易感植物和动物中增加抗病性的方法。

    Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
    5.
    发明授权
    Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals 失效
    细菌菌株，基因和酶通过淬灭群体感应信号来控制细菌性疾病

    公开(公告)号：US07410638B1

    公开(公告)日：2008-08-12

    申请号：US10362569

    申请日：2000-08-23

    申请人： Lianhui Zhang ,  Yihu Dong ,  Haibao Zhang ,  Jinling Xu

    发明人： Lianhui Zhang ,  Yihu Dong ,  Haibao Zhang ,  Jinling Xu

    IPC分类号： C12N9/54 ,  C12N15/00 ,  C12N1/20 ,  C07H21/04 ,  A61K38/48

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C12N15/8281

    摘要： The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting of 104HXHXDH109˜60aa˜H169˜21aa˜D191 and 103HXHXDH108˜72aa˜H180˜21aa˜D202, and to expression vectors and transformed plant and animal cells comprising the same. The proteins encoded by these nucleic acid molecules provide to a susceptible plant or animal increased resistance to a disease the virulence of which is regulated by autoinducers. Also provided are methods of increasing disease resistance in susceptible plants and animals.

    摘要翻译： 本发明涉及编码自身诱导失活蛋白的分离的核酸分子，其中编码的蛋白质包含选自以下的氨基酸序列： HXHXDH 109〜 H16H1HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH >〜21aa〜D 202，以及表达载体和包含其的转化的植物和动物细胞。 由这些核酸分子编码的蛋白质提供给敏感植物或动物增加的抗病毒性，其毒性由自动诱导剂调节。 还提供了在易感植物和动物中增加抗病性的方法。

    Control of leaf scald disease
    6.
    发明授权
    Control of leaf scald disease 失效
    控制叶烫伤病

    公开(公告)号：US06388175B1

    公开(公告)日：2002-05-14

    申请号：US09029785

    申请日：1998-03-09

    申请人： Robert Birch ,  Lianhui Zhang

    发明人： Robert Birch ,  Lianhui Zhang

    IPC分类号： C12N504

    CPC分类号： C12R1/18 ,  A01N63/00 ,  C07K14/225 ,  C12N9/00 ,  C12N9/14 ,  C12N15/74 ,  C12N15/8281

    摘要： A method of substantially reducing or inhibiting the development of leaf scald disease in a plant or stalk thereof, said method comprising the step of administering an albicidin detoxification enzyme to the plant or stalk thereof. There is also provided a method of generating a transgenic plant substantially resistant to albicidin and leaf scald disease including the steps of introducing and expressing a nucleotide sequence encoding albicidin detoxification enzyme into a plant, plant part or plant cell, and growing the plant, plant part or plant cell to generate the transgenic plant. There is further provided a method of substantially reducing or inhibiting the development of leaf scald disease in a plant or stalk thereof, said method comprising the step of administering to the plant or stalk thereof a bacterium which extracellularly produces albicidin detoxification enzyme. There is further provided an isolated albicidin detoxification enzyme capable of irreversibly inactivating albicidin as well as an isolated nucelotide sequence encoding an albicidin detoxification enzyme.

    摘要翻译： 一种显着减少或抑制植物或其茎中叶片烫伤疾病发展的方法，所述方法包括向植物或其茎施用albicidin解毒酶的步骤。还提供了一种基本上产生转基因植物的方法 对albicidin和叶片烫伤具有抗性，包括将编码albicidin解毒酶的核苷酸序列引入并表达到植物，植物部分或植物细胞中的步骤，以及生长植物，植物部分或植物细胞以产生转基因植物。 提供了一种显着减少或抑制植物或其茎中叶片烫伤疾病发展的方法，所述方法包括向植物或茎施用细胞外产生albicidin解毒酶的细菌的步骤。还提供了分离的albicidin 解毒酶能够不可逆地灭活albicidi n以及编码albicidin解毒酶的分离的杀虫肽序列。

    BACTERIAL STRAINS, GENES AND ENZYMES FOR CONTROL OF BACTERIAL DISEASES BY QUENCHING QUORUM-SENSING SIGNALS
    8.
    发明申请
    BACTERIAL STRAINS, GENES AND ENZYMES FOR CONTROL OF BACTERIAL DISEASES BY QUENCHING QUORUM-SENSING SIGNALS 失效
    细菌菌株，通过检测感测信号控制细菌病的基因和酶

    公开(公告)号：US20080182790A1

    公开(公告)日：2008-07-31

    申请号：US11972777

    申请日：2008-01-11

    申请人： Lianhui ZHANG ,  Yihu DONG ,  Haibao ZHANG ,  Jinling XU

    发明人： Lianhui ZHANG ,  Yihu DONG ,  Haibao ZHANG ,  Jinling XU

    IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  A61P31/04 ,  C12N1/00 ,  C07K14/32

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C12N15/8281

    摘要： The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group consisting of 104HXHXDH109˜60aa˜H169˜21aa˜D191 and 103HXHXDH108˜72aa˜H180˜21aa˜D202, and to expression vectors and transformed plant and animal cells comprising the same. The proteins encoded by these nucleic acid molecules provide to a susceptible plant or animal increased resistance to a disease the virulence of which is regulated by autoinducers. Also provided are methods of increasing disease resistance in susceptible plants and animals.

    摘要翻译： 本发明涉及编码自身诱导失活蛋白的分离的核酸分子，其中编码的蛋白质包含选自以下的氨基酸序列： HXHXDH 109〜 H16H1HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH >〜21aa〜D 202，以及表达载体和包含其的转化的植物和动物细胞。 由这些核酸分子编码的蛋白质提供给敏感植物或动物增加的抗病毒性，其毒性由自动诱导剂调节。 还提供了在易感植物和动物中增加抗病性的方法。