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    MICROFLUIDIC CHIPS FOR ACQUIRING SPERMS WITH HIGH MOTILITY, PRODUCTIONS AND APPLICATIONS THEREOF
    1.
    发明申请
    MICROFLUIDIC CHIPS FOR ACQUIRING SPERMS WITH HIGH MOTILITY, PRODUCTIONS AND APPLICATIONS THEREOF 审中-公开
    用于获取具有高动力，生产和应用的气体的微流体

    公开(公告)号：US20140315281A1

    公开(公告)日：2014-10-23

    申请号：US14344866

    申请日：2012-09-14

    Applicant: Richard Li-Chern Pan

    Inventor： Richard Li-Chern Pan

    IPC: C12N5/076

    CPC classification number: C12N5/061 ,  B01L3/5027 ,  B01L2300/028 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/084 ,  B01L2400/086 ,  C12M21/06 ,  C12M23/16 ,  G01N33/5029

    Abstract: This invention relates to microfluidic chips for and their applications in acquiring sperms with high velocity and/or motility. The microfluidic chip comprises an inlet region, a first flow channel, a divergent channel, an optional block structure with rounded corners and one or more outlet region(s). The invention mimics sperm activation process in body and designs a microfluidic chip mimicking the activation process so that higher amount of populations and/or subpopulations of sperms with high motility can be acquired.

    Abstract translation: 本发明涉及用于获取具有高速度和/或运动性的精子的微流控芯片及其应用。 微流体芯片包括入口区域，第一流动通道，发散通道，具有圆角的可选块结构和一个或多个出口区域。 本发明模仿身体中的精子活化过程，并设计模拟激活过程的微流体芯片，从而可以获得具有高活力的精子数量和/或亚群。

    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors
    2.
    发明授权
    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors 有权
    与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件

    公开(公告)号：US08007726B2

    公开(公告)日：2011-08-30

    申请号：US11806786

    申请日：2007-06-04

    Applicant: Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    Inventor： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC: G01N27/00 ,  G01N7/00 ,  G01N15/06

    CPC classification number: G01N27/4145 ,  G01N27/4148

    Abstract: The present invention provides a microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors. The present invention utilizes a micro-electro-mechanical process as well as a semiconductor process to integrate microarray bioprobes and an amplifier having bottom-gate thin film transistors on a flexible substrate. As such, a signal obtained by the microarray bioprobes can be amplified nearby to improve the signal-to-noise ratio and impedance matching. The microarray bioprobes are formed on the flexible substrate such that the present microarray bioprobe device can be disposed to conform to the profile of a living body's portion so as to improve electrical contact between the bioprobes and the living body's portion.

    Abstract translation: 本发明提供了一种与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件。 本发明利用微机电工艺以及半导体工艺将微阵列生物探针和具有底栅薄膜晶体管的放大器集成在柔性衬底上。 因此，通过微阵列生物探针获得的信号可以在附近放大，以提高信噪比和阻抗匹配。 微阵列生物探针形成在柔性基底上，使得本发明的微阵列生物探针装置可以被设置成符合活体部分的轮廓，以改善生物探针与生物体部分之间的电接触。

    KIT AND METHOD FOR THE CAPTURE OF TUMOR CELLS
    3.
    发明申请
    KIT AND METHOD FOR THE CAPTURE OF TUMOR CELLS 有权
    用于肿瘤细胞捕获的试剂盒和方法

    公开(公告)号：US20110159561A1

    公开(公告)日：2011-06-30

    申请号：US12649026

    申请日：2009-12-29

    Applicant: Richard Li-Chern Pan ,  Fang-Chi Hsu

    Inventor： Richard Li-Chern Pan ,  Fang-Chi Hsu

    IPC: C12N13/00 ,  C12N11/16 ,  C12N11/08

    CPC classification number: C12N5/0693 ,  C12N5/0697 ,  C12N2502/1135 ,  C12N2502/28 ,  C12N2502/30

    Abstract: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample or a serum-containing sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be identified.

    Abstract translation: 本发明涉及用于在体液样品或含血清样品中捕获肿瘤细胞的试剂盒和方法。 本发明的试剂盒和方法可以捕获活肿瘤细胞，而不是非活体肿瘤细胞或细胞片段，从而可以通过进一步培养所捕获的肿瘤细胞进一步鉴定肿瘤物种。 此外，本发明的试剂盒和方法可以容易地鉴定样品是否含有肿瘤细胞并收集这些肿瘤细胞用于进一步鉴定，以便可以鉴定癌症的存在以及转移和早期复发的发展。

    Microarray bioprobe device integrated with a semiconductor amplifier module on a flexible substrate
    5.
    发明授权
    Microarray bioprobe device integrated with a semiconductor amplifier module on a flexible substrate 失效
    微阵列生物探针器件与柔性基板上的半导体放大器模块集成

    公开(公告)号：US07805175B2

    公开(公告)日：2010-09-28

    申请号：US11545687

    申请日：2006-10-11

    Applicant: Jium Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    Inventor： Jium Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC: A61B5/04

    CPC classification number: B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653

    Abstract: The present invention provides a microarray bioprobe device integrated with a semiconductor amplifier module, which integrates micro array biological probes and thin film transistors on a flexible substrate by Micro-Electro-Mechanical System (MEMS) processes and semiconductor processes. A signal from the microarray bioprobe device is amplified through a near amplifier to increase signal-to-noise ratio and impendence matching. The micro array biological probes of the present invention are produced on the flexible substrate such that the micro array biological probes can be disposed to conform to the profile of a living body's portion and improving contact between the probes and living body's portion.

    Abstract translation: 本发明提供了一种与半导体放大器模块集成的微阵列生物探针器件，该半导体放大器模块通过微电子机械系统（MEMS）工艺和半导体工艺在柔性衬底上集成微阵列生物探针和薄膜晶体管。 来自微阵列生物探针器件的信号通过近放大器放大，以增加信噪比和阻抗匹配。 本发明的微阵列生物探针在柔性基板上制造，使得微阵列生物探针可以被设置成符合生物体部分的轮廓并改善探针与活体部分之间的接触。

    Bone implants
    6.
    发明申请
    Bone implants 有权
    骨植入物

    公开(公告)号：US20060190091A1

    公开(公告)日：2006-08-24

    申请号：US11063074

    申请日：2005-02-22

    Applicant: Wen-Fu Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    Inventor： Wen-Fu Lai ,  Li-Chern Pan ,  Pau-Yee Lim ,  Jung-Chou Oung ,  Chun-Wei Chen

    IPC: A61F2/28

    CPC classification number: A61L27/50 ,  A61L27/06 ,  A61L27/24 ,  A61L27/34 ,  A61L2430/02 ,  C08L89/06

    Abstract: This invention relates to a bone implant that includes a bioinert substrate covered with a ceramic layer containing a plurality of indentations. The total surface area of the indentations is 30-70% of the total surface area of the ceramic layer. This invention also relates to a method of preparing such a bone implant. The method includes: (1) affixing a ceramic layer on the surface of a bioinert substrate; (2) forming a plurality of indentations in the ceramic layer, wherein the total surface area of the indentations is 30-70% of the total surface area of the ceramic layer; and (3) immobilizing a biopolymer onto the ceramic layer via covalent bonding.

    Abstract translation: 本发明涉及一种骨植入物，其包括用包含多个凹陷的陶瓷层覆盖的生物惰性基底。 压痕的总表面积为陶瓷层总表面积的30-70％。 本发明还涉及一种制备这种骨植入物的方法。 该方法包括：（1）在生物惰性基材的表面上固定陶瓷层; （2）在陶瓷层中形成多个凹陷，其中凹陷的总表面积为陶瓷层的总表面积的30-70％; 和（3）通过共价键将生物聚合物固定在陶瓷层上。

    METHOD USING MICROFLUIDIC CHIP TO SORT HIGH MOTILITY SPERM
    7.
    发明申请
    METHOD USING MICROFLUIDIC CHIP TO SORT HIGH MOTILITY SPERM 审中-公开
    使用微流控芯片排除高电流密度的方法

    公开(公告)号：US20100291535A1

    公开(公告)日：2010-11-18

    申请号：US12546267

    申请日：2009-08-24

    Applicant: Da-Jeng Yao ,  Tsung-Lin Wu ,  Fan-Gang Tseng ,  Li-Chern Pan ,  Hong-Yuan Huang

    Inventor： Da-Jeng Yao ,  Tsung-Lin Wu ,  Fan-Gang Tseng ,  Li-Chern Pan ,  Hong-Yuan Huang

    IPC: A01N1/02

    CPC classification number: C12N5/0612

    Abstract: The present invention discloses a method using a microfluidic chip to sort high motility sperm. In the present invention, sperm and a medium are respectively injected into a microchannel of a microfluidic chip via several inlets. Owing to the characteristic of microfluidics, the sperm and the medium form a sperm laminar flow and medium laminar flow in the microchannels; the sperm laminar flow and the medium laminar flow are parallel to each other. The higher motile sperm may pass through at least one laminar flow within a limited time, whereby different motility levels of sperm can be respectively collected from different outlets.

    Abstract translation: 本发明公开了一种使用微流体芯片分选高活力精子的方法。 在本发明中，通过多个入口将精子和培养基分别注入微流体芯片的微通道。 由于微流体的特点，精子和培养基在微通道中形成精子层流和中层流; 精子层流和介质层流彼此平行。 较高活动精子可以在有限的时间内通过至少一个层流，从而可以从不同的出口分别收集精子的不同运动水平。

    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors
    9.
    发明申请
    Microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors 有权
    与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件

    公开(公告)号：US20080297135A1

    公开(公告)日：2008-12-04

    申请号：US11806786

    申请日：2007-06-04

    Applicant: Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    Inventor： Jium-Ming Lin ,  Li-Chern Pan ,  Po-Wei Lin

    IPC: G01N27/00

    CPC classification number: G01N27/4145 ,  G01N27/4148

    Abstract: The present invention provides a microarray bioprobe device integrated with an amplifier having bottom-gate thin film transistors. The present invention utilizes a micro-electro-mechanical process as well as a semiconductor process to integrate microarray bioprobes and an amplifier having bottom-gate thin film transistors on a flexible substrate. As such, a signal obtained by the microarray bioprobes can be amplified nearby to improve the signal-to-noise ratio and impedance matching. The microarray bioprobes are formed on the flexible substrate such that the present microarray bioprobe device can be disposed to conform to the profile of a living body's portion so as to improve electrical contact between the bioprobes and the living body's portion.

    Abstract translation: 本发明提供了一种与具有底栅薄膜晶体管的放大器集成的微阵列生物探针器件。 本发明利用微机电工艺以及半导体工艺将微阵列生物探针和具有底栅薄膜晶体管的放大器集成在柔性衬底上。 因此，通过微阵列生物探针获得的信号可以在附近放大，以提高信噪比和阻抗匹配。 微阵列生物探针形成在柔性基底上，使得本发明的微阵列生物探针装置可以被设置成符合活体部分的轮廓，以改善生物探针与生物体部分之间的电接触。

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